Synthesis, photolumescence properties, solvent effect in molecular structure level, topology, and docking studies on Sulfa drug derivative.

This study examines the analysis of infrared, Raman, electronic spectral analysis, and H, C NMR spectra. Additionally, it investigates the features of NBO properties. A study was done to investigate the electronic transition and FMOs in the gas and different solvent phases like ethanol, DMSO, and HO.

Solvent-driven spectroscopic and quantum chemical evaluation of 2-[(trimethylsilyl) ethynyl]thiophene with molecular docking insights.

Thiophene derivatives are recognised for their notable biological and pharmacological properties. This study examines the electronic structure and antibacterial properties of 2-[(Trimethylsilyl)ethynyl]thiophene (2TSET), emphasising the effects of solvent environments. We utilised spectroscopic techniques such as Fourier transform infrared (FT-IR), ultraviolet-visible (UV-Vis), and Raman spectroscopy (FT-Raman) to verify the molecular geometry of 2TSET.

Bcl-2 binding component 3 (BBC3) as a precision biomarker in breast cancer.

Breast cancer is the most prevalent carcinoma in women globally, and the identification of sensitive and specific serum biomarkers is important for its early detection, monitoring, and prognosis. Bcl-2 binding component 3 (BBC3), also known as p53 upregulated modulator of apoptosis (PUMA), is a proapoptotic- BH3-only protein whose dysregulated expression in tumor tissues and circulation implicates it as a potential diagnostic biomarker. However, the analytical performance, preanalytical- requirements, and clinical utility of serum BBC3 quantification have not been rigorously assessed according to clinical chemistry- standards.

Enhancement of low-density polyethylene biodegradation through the production of surface-active compounds by Pluralibacter gergoviae TYB1.

Pluralibacter gergoviae TYB1 is a facultative anaerobic bacterium with a high efficiency of low-density polyethylene (LDPE) degradation using self-producing surface-active compounds (SACs). This bacterium was used for the degradation of LDPE. In this study, analysis was performed to check the SAC production efficiency of P.

Pharmaceutical residues and chemicals in landfill leachate from a sanitary landfill in Malaysia: non-target analysis and records of health and environmental hazards.

Pharmaceutical residues (PRs) and pharmaceutical chemicals (PCs) have been detected in landfill leachate though landfill sites have no direct role in managing pharmaceutical wastes. However, their detailed exploration is still challenging in leachate samples due to their vast array of metabolites and complex interactions. The present study is aimed to perform a non-target analysis of PRs and PCs in leachate from a sanitary landfill in Malaysia.

Removal of high concentrations of zinc, cadmium, and nickel heavy metals by Bacillus and Comamonas through microbially induced carbonate precipitation.

Heavy metal pollution in urban freshwater, driven by anthropogenic activities, poses significant risks to aquatic ecosystems and human health due to its toxicity and persistence. Recently, urease-producing bacteria have gained attention for their ability to remove heavy metals through microbial-induced carbonate precipitation (MICP). In this study, eight urease-producing bacteria were exposed to individual solutions of zinc (Zn), cadmium (Cd), and nickel (Ni) at concentrations ranging from 0 to 6 mM to assess their resistance.

Safety assessment of resveratrol surrogate molecule 5 (RSM5): Acute and sub-acute oral toxicity studies in BALB/c mice.

Natural polyphenols have gained greater attention for their potent medicinal properties and potential benefits in addressing various health concerns. Resveratrol, a polyphenolic compound known for its therapeutic properties, has shown limitations in bioavailability, which the novel derivative resveratrol surrogate molecule (RSM5) aims to improve. The present study evaluates the oral toxicity and safety profile of a novel resveratrol derivative through acute and subacute assessments.

Urease-catalyzed microbial and enzymatic carbonate precipitation for eco-friendly heavy metal remediation.

Heavy metal contamination significantly threatens environmental and public health, necessitating effective and sustainable remediation technologies. This review explores two innovative bioremediation techniques: microbially induced calcium carbonate precipitation (MICP) and enzyme-induced calcium carbonate precipitation (EICP). Both techniques show promise for immobilizing heavy metals in laboratory and field settings.

Pharmaceutical waste management legislations: Where do ASEAN countries stand in harmonization? A review of regulatory documents.

Although healthcare waste management (HCWM) legislations prevail in Association of Southeast Asian Nations (ASEAN), there appears a prominent gap in standalone pharmaceutical waste management (PWM) legislation making harmonization of PWM challenging in the region. This review is aimed to comprehensively overview the PWM-related legislations in ASEAN, comprising of 10 economically rising countries in Southeast Asia. The relevant regulatory documents, that were promulgated till August 31, 2024 and that were in English or officially translated in English, were extracted from PubMed/Medline, Scopus, Science Direct, Google Scholar, and respective country's government websites.

Enhanced MICP for Soil Improvement and Heavy Metal Remediation: Insights from Landfill Leachate-Derived Ureolytic Bacterial Consortium.

This study investigates the potential of microbial-induced calcium carbonate precipitation (MICP) for soil stabilization and heavy metal immobilization, utilizing landfill leachate-derived ureolytic consortium. Experimental conditions identified yeast extract-based media as most effective for bacterial growth, urease activity, and calcite formation compared to nutrient broth and brown sugar media. Optimal MICP conditions, at pH 8-9 and 30 °C, supported the most efficient biomineralization.

Targeting Nudix Hydrolase 5 with Bioactive Flavonoids: Molecular Dynamics and Docking Studies for Breast Cancer Therapy.

Breast cancer (BC) is the most prevalent malignancy among women globally and the leading cause of cancer-related mortality. Consequently, there is an urgent need for new, effective treatment strategies for breast cancer. Research has shown that the enzyme nudix hydrolase 5 (NUDT5) plays a critical role in promoting breast cancer aggressiveness and serves as a key regulator of oncogenic pathways.

Comments on "Extraction, purification, characteristics, bioactivities, prospects, and toxicity of Lilium spp. polysaccharides by Li et al. (2024) in Int. J. Biol. Macromol.".

Lilium spp. polysaccharides (LSPs) are gaining significant attention for their diverse health benefits, including antioxidant, antitumor, and antibacterial properties. This paper critically analyzes a recent comprehensive review by Li et al.

Sodium arsenite-induced DNA methylation alterations exacerbated by p53 knockout in MCF7 cells.

Epigenetic alterations are ubiquitous across human malignancies. Thus, functional characterization of epigenetic events deregulated by environmental pollutants should enhance our understanding of the mechanisms of carcinogenesis and inform preventive strategies. Recent reports showing the presence of known cancer-driving mutations in normal tissues have sparked debate on the importance of non-mutational stressors potentially acting as cancer promoters.

Investigation of Uncovering Molecular Mechanisms of Alcohol-Induced Female Infertility-A Rational Approach.

This study aimed to investigate the molecular mechanisms by which chronic alcohol consumption impacts female infertility, highlighting significant societal implications. By conducting a comprehensive literature review, we examined existing evidence on the association between long-term alcohol use and female reproductive health. Relevant studies were identified through systematic searches of electronic databases and key journals.

Harnessing Phytochemicals to Regulate Catalytic Residues of Alpha-Amylase and Alpha-Glucosidase in Type 2 Diabetes.

Type 2 diabetes (T2D), also known as non-insulin-dependent diabetes mellitus, represents the prevailing manifestation of diabetes, encompassing a substantial majority of cases, ~90-95%. Plant-derived antidiabetic leads are being intensively explored due to their safety and effectiveness. The main objective of the present study is to evaluate the anti-diabetic potential of the traditional formulation Karisalai Karpam through in-vitro and in-silico investigations.

Hierarchical TiCT MXene@Honeycomb nanocomposite with high energy efficiency for solar water desalination.

The utilization of solar-driven interfacial evaporation holds immense promise in enhancing energy efficiency and establishing sustainable methods for seawater desalination and water purification. While designing the materials to achieve high evaporation efficiency, the tuning of materials with porosity and surface chemistry is very crucial. Novel sustainable materials are of great importance for solar water desalination applications since clean water production is utmost important in the current era.

Establishing network pharmacology between natural polyphenols and Alzheimer's disease using bioinformatic tools - An advancement in Alzheimer's research.

Alzheimer's disease (AD) is a major cause of disability and one of the top causes of mortality globally. AD remains a major public health challenge due to its prevalence, impact on patients and caregivers, and the current lack of a cure. In recent years, polyphenols have garnered attention for their potential therapeutic effects on AD.

Synergistic effects of starch and carrageenan from Kappaphycus alvarezii in composite film formation: Physicochemical and degradable properties.

Rising concerns around plastic pollution from single-use plastic (SUPs), especially food packaging, have driven interest in sustainable alternatives. As such, algae biomass has gained attention for bioplastic production due to algae's rapid growth and abundant polysaccharides. This research focuses on extracting carrageenan from Kappaphycus alvarezii, extensively cultivated in Sabah, Malaysia, and utilizing it in combination with starch and glycerol to develop algae-based films.

Two decades of research trends in microbial-induced carbonate precipitation for heavy metal removal: a bibliometric review and literature review.

Amidst the increasing significance of innovative solutions for bioremediation of heavy metal removal, this paper offers a thorough bibliometric analysis of microbial-induced carbonate precipitation (MICP) for heavy metal removal, as a promising technology to tackle this urgent environmental issue. This study focused on articles published from 1999 to 2022 in the Scopus database. It assesses trends, participation, and key players within the MICP for heavy metal sequestration.

Geographic information systems adoption model: A partial least square-structural equation modeling analysis approach.

The ability of Geographic Information System (GIS) to organize, analyze, visualize and integrate spatial data has been at the top of its primary uses among professional industries. However, considering the extensive adoption of Information System (IS) throughout history for government organizations' or citizens' disaster response, the implementation of geographical elements is still minimal. Previous GIS models and framework studies, particularly in developing countries, were affected by pandemic pressure, competitiveness pressure, change management, and security factors.

Bibliometric analysis of research trends in biogranulation technology for wastewater treatment.

Inadequate management and treatment of wastewater pose significant threats, including environmental pollution, degradation of water quality, depletion of global water resources, and detrimental effects on human well-being. Biogranulation technology has gained increasing traction for treating both domestic and industrial wastewater, garnering interest from researchers and industrial stakeholders alike. However, the literature lacks comprehensive bibliometric analyses that examine and illuminate research hotspots and trends in this field.

Repurposing cardiac glycosides for anticancer treatment: a review of clinical studies.

Cardiac glycosides (CGs), which are traditionally used for heart disease, show promise for cancer therapy. However, there is a lack of a comprehensive review of clinical studies in this area, and so far, CGs have not been widely integrated into clinical cancer treatment. This review covers clinical studies from the past five years, highlighting the potential of CGs to reduce cancer risk, enhance chemotherapy effectiveness, mitigate chemotherapy-induced side effects and improve quality of life.

A Comparative Analysis Assessing Growth Dynamics of Locally Isolated Chlorella sorokiniana and Chlorella vulgaris for Biomass and Lipid Production with Biodiesel Potential.

Prior research has emphasized the potential of microalgae in biodiesel production, driven by their ability to replace fossil fuels. However, the significant costs associated with microalgae cultivation present a major obstacle to scaling up production. This study aims to develop an eco-friendly microalgae cultivation system by integrating carbon dioxide from flue gas emissions with an affordable photobioreactor, providing a sustainable biomass production.

Entanglement and quantum coherence of two YIG spheres in a hybrid Laguerre-Gaussian cavity optomechanics.

We theoretically investigate continuous variable entanglement and macroscopic quantum coherence in the hybrid L-G rotational cavity optomechanical system containing two YIG spheres. In this system, a single L-G cavity mode and both magnon modes (which are due to the collective excitation of spins in two YIG spheres) are coupled through the magnetic dipole interaction whereas the L-G cavity mode can also exchange orbital angular momentum (OAM) with the rotating mirror (RM). We study in detail the effects of various physical parameters like cavity and both magnon detunings, environment temperature, optorotational and magnon coupling strengths on the bipartite entanglement and the macroscopic quantum coherence as well.