Biochemical Ferrous Ions (Fe2+) Mediated Fenton Reaction: A Biological Prodigy for Curing and Developing Autoimmune Rheumatoid Arthritis and Cancer.

Iron is an essential trace element for the human body, but having too much or too little of it can cause various biological issues. When ferrous ions react with hydrogen peroxide, they create highly reactive and soluble hydroxyl radicals that can damage cells through oxidation. This reaction, known as the Fenton reaction, can cause lipid peroxidation and ferroptosis.

NiFeO@PEG Nanomaterials Mediated Synthesis of Functionalized Pyrroles via a Multi-Component Reaction under Mild Conditions.

We report the synthesis of NiFeO NPs via the hydrothermal approach in the presence of PEG as a capping agent. The diffractometric and microscopic study confirms the formation of a mixture of nonuniform cube and spherical-shaped cubic crystalline NiFeO NPs. PEG acts as a capping agent which controls the crystallite size of the formed particles but it does not have much influence on the size of the particles.

Exploring impact of cold atmospheric plasma directed self-assembly of glycated bovine serum albumin.

Bovine Serum Albumin (BSA) is a globular, water-soluble protein widely used as a model system due to its stability, binding capacity, and structural similarity to human serum albumin (HSA). Cold atmospheric plasma (CAP) has emerged as a versatile tool for biomolecule modification, sterilization, food preservation, and wound healing. This study explores the effects of CAP on glycated BSA, focusing on structural and self-assembly processes.

Common Nefafu ( L.)-Mediated Silver Nanoparticles for Physicochemical Insights into the Protein Corona Formation and Inhibition of Fibrillation of Human Serum Albumin.

Engineering nanomaterials with products isolated from natural resources is attractive for targeted therapeutic applications. Prior to the biomedicinal applications, one significant facet of nanoparticles is the understanding of protein corona formation and its relative binding aspects. In this perspective, we have synthesized two different silver nanoparticles, one with the extract of the leaves of a traditional herb , commonly known as "Nefafu", and the other with one of its major polyphenolic compounds, apigenin, and their complexations were studied with the model protein human serum albumin (HSA).

Bioactive catechins from Potentilla fulgens Wall. ex Sims roots ameliorate oral carcinogenesis through modulation of oxidative stress, inflammatory, and apoptotic pathways.

Ethnopharmacological Relevance: Potentilla fulgens (PF) roots commonly known as 'Bajradanti' are widely used by indigenous tribes of Northeast India to treat oral diseases. Pieces of the roots were chewed as herbal remedy along with areca-nut to alleviate its harmful effects. While PF showed anticancer property in the gastrointestinal tract, its effects on oral cancer remain unexplored.

Nitro-Substituted Benzylic Organochalcogenides as Anticancer Agents: Unravelling the Multifaceted Pathways to Combat Triple-Negative Breast Cancer.

Organochalcogens exhibit promising chemotherapeutic potential against several cancer types. However, their ability to simultaneously target interconnected oncogenic signaling networks remains mostly unexplored. Herein, we report 4-nitro-substituted benzylic diselenide , which exhibits concerted inhibition of Akt/mTOR and ERK pathways with the suppression of NF-κB-mediated inflammation and invasiveness against the highly aggressive triple-negative breast cancer MDA-MB-231 cells.

The commercial polyvalent antivenom against the "Big Four" venomous snakes of India shows poor immune recognition and neutralization of lethality and toxicity of Trimeresurus popeiorum venom proteins in the mouse model.

In tropical areas, especially India, where the "Big Four" snakes cause most snakebite cases, envenomation is still a significant public health issue. Trimeresurus popeiorum (Pope's pit viper), a species prevalent in Northeast India, remains neglected despite its medical importance. This study examines the immunological cross-reactivity and efficacy of Indian commercial polyvalent antivenoms (PAVs) in neutralizing T.

Positional distribution of transcription factor binding sites in the human genome.

As transcription factors (TFs) play a major role in gene regulation, we studied their binding motifs (positional weight matrices, PWMs) and binding sites (TFBSs) in the human genome, and how TFs bind DNA motifs, including the involvement of binding co-factors. Using the chromatin immunoprecipitation sequencing data recently released by ENCODE (Encyclopedia of DNA Elements), we obtained new PWMs for 196 TFs and revised PWMs for 119 TFs. From these and the PWMs previously obtained for 235 TFs, we inferred the canonical PWMs for 500 TFs, including 243 new PWMs.

Correlation of specific addictions with cancer sites identified among patients in Northeast India.

Dietary habits are unique to geography and may exert crucial influence in the commencement of many diseases, including cancer. North-eastern region of India, exhibit unique food habits and are different from the rest of the country. This study investigates the association between dietary habits and site-specific cancer occurrence among patients registered with the North East Cancer Hospital and Research Institute (NECHRI) in 2022.

Interplay of miR-243 and microbial interactions in aging and transgenerational immunity.

MicroRNAs (miRNAs) function in post-transcriptional regulation of gene expression and influence numerous biological processes. This commentary and view provide integrated insights from Kumar et al. (2024) and Gabaldon et al.

Proteomic profiling and biochemical characterization of enzymatic and non-enzymatic proteins of Heterometrus bengalensis venom and their pathophysiological functions in the Swiss albino mice model.

Due to its significant mortality and morbidity, scorpion sting is a public health concern worldwide, particularly in tropical and subtropical regions. Heterometrus bengalensis (HB) significantly impacts health; however, HB's venom composition is the least characterized. The present study provides a comprehensive insight into the HB venom (HBV) profile by in vitro enzyme assay and tandem mass spectrometry analysis of SDS-PAGE-separated venom proteins and peptides.

Functional impact of bioactive peptides derived from fermented foods on diverse human populations.

Bioactive peptides from fermented foods are gaining global attention for their health benefits. These short peptides, formed during fermentation, interact with biomolecules through electrostatic forces, hydrogen bonding, and hydrophobic interactions to exert antimicrobial, antihypertensive, antioxidant, and immune-modulatory effects. Fermented foods, including dairy, soybeans, vegetables, and fish, are rich sources of these peptides, which influence cardiac function, immune response, and metabolic health.

Unraveling labile carbon and soil enzyme dynamics across seasons and sediment layers in Deepor Beel: a degraded freshwater wetland in Assam, India.

Seasonal shifts in climatic conditions can significantly influence biotic and abiotic parameters in wetland ecosystems. This study evaluated the seasonal, spatial, and depth-wise variations in labile organic carbon (LOC) [permanganate oxidizable carbon (POXC), light fraction organic carbon (LFOC), and dissolved organic carbon (DOC)] and soil enzyme activities [β-glucosidase (BG), dehydrogenase (DHA), and amylase] in Deepor Beel sediments. Two-way ANOVA and t-tests revealed that seasonal changes had stronger influences than sediment depth on LOC and enzyme activities, with LOC peaking during the post-monsoon (POM) season.

Therapeutic insights into Garcinia mangostana: Bioactivities, challenges, and future directions in drug discovery.

Garcinia mangostana is a tropical tree native to India, Sri Lanka, and Southeast Asia. In Traditional Medicinal Systems (TMS), decoctions and infusions prepared from mangosteen fruits have effectively treated skin lesions and various inflammatory conditions. Researchers have also reported its extensive biological activities, viz.

Review on Advancement of AI in Cell Engineering and Molecular Biology.

Artificial intelligence is emerging as an important domain in the scientific field with the potential to provide advancements in molecular biology and cell engineering to improve the quality of life of human beings. The convergence of AI and related technologies linked with biology can lower the technical and knowledge barriers in numerous areas, such as diagnostics and forecasting. Artificial intelligence (AI) and machine learning tools are revolutionizing life science research and biomedical applications.

AI-Assisted Cell Culture System.

Artificial intelligence (AI) proves to be a great tool that makes it possible for machines to learn from experience, regulate to new inputs, and execute human-like activities. AI is already the prime driver of emerging technologies and there are further possibilities in different fields. Certainly, the technology has not yet reached its full effectiveness in many fields but there is one area where AI, integrated with automation, can greatly improve laboratory research known as cell culture.

AI-Based Drug Discovery and Design for Different Genetic Designs.

Personalized medicine, also known as precision medicine, is a branch of medicine that considers each patient's unique genetic makeup, lifestyle, and environment to customize treatment plans, preventative measures, and diagnoses. By tailoring medical interventions to individual genetic profiles, personalized medicine maximizes treatment efficacy. Better health outcomes and less trial-and-error in therapy selection result from this method, which guarantees that patients receive medicines that are most likely to work for them.

Tuning the physical properties of SnO quantum dots Ag-doping for fabricating efficient photodetectors.

In order to satisfy the increasing demand for affordable photodetectors in the sectors of flexible electronics and contemporary medical devices in this decade, researchers are looking for efficient semiconducting nanomaterials globally. Ag-doped SnO quantum dots (QDs) with varying Ag ion concentrations were synthesized chemical co-precipitation for efficient photodetector fabrication. The impact of Ag dopants on SnO QDs properties was analyzed through multiple characterization techniques.

Unlocking the therapeutic potential of bioactive compounds in : a new frontier in natural medicine.

(Reishi), a valued medicinal fungus used in traditional medicine for over 2000 years, has sparked widespread scientific attention due to its extensive range of bioactive ingredients and therapeutic promise in modern medicine. This study presents a detailed and up-to-date examination of primary bioactive components, which include polysaccharides, triterpenoids, meroterpenoids, nucleotides, proteins, alkaloids, and sesquiterpenoids. These chemical components show a wide range of pharmacological effects, including immune modulation, cancer suppression, and neuroprotection.

Comparative analysis of endophytic bacterial localization and microbiome diversity in plant varieties under varied growth conditions through microscopic imaging and sequencing techniques.

Introduction: Intracellular colonization by endophytic bacteria (EB) is a relatively new and less explored aspect of plant microbiome research. In this study, we investigated the presence and localization of EB in var. Podali and var.

A comprehensive review of scientifically reported phytochemicals to manage allodynia in chronic diabetes complications.

Background: The global prevalence of diabetes mellitus and its associated complications is increasing, impacting both developed and developing nations. One common complication is neuropathy and neuropathic pain, which often manifests as symptoms such as allodynia-a condition where patients experience pain from non-painful stimuli.

Objective: This review seeks to explore scientifically validated medicinal plants and phytochemicals, presenting the findings in an organized format based on published literature.

Manifesting p-d Orbital Hybridization Through Strategic D-Band Engineering: A Pathway to Boosted Bifunctional HER/OER Electrochemical Performance in Self-Templated Co-SnO Grown Over Co-SnS Nanosheets.

In this study, Co-doped SnO is synthesized atop the hexagonal CoS template (CoSS) via direct air calcination of as-synthesized Co-doped SnS (CoS) nanosheets. The structural evolution facilitated the emergence of Co and Co states, complemented by surface-adsorbed sulfur oxyanions (SO , HSO , SO ). CoSS deposited over carbon cloth (CoSS/CC) exhibited superior bifunctional HER and OER, demonstrating higher stability and efficiency than their CoS/CC counterparts.

Optimization of expression and renaturation methods for the production of a recombinant fibrinolytic protease showing in vivo antithrombotic activity.

Bacterial fibrinolytic enzymes are promising in treating thrombosis-associated cardiovascular disease. The recombinant fibrinolytic enzymes exhibiting enhanced specificity and improved pharmacokinetics, being less immunogenic and easy to produce, can be advantageous over wild-type enzymes. However, efficient expression and refolding of recombinant enzymes is a significant challenge; therefore, three different analytical methods were compared in this study for the efficient expression and refolding of a recombinant fibrinolytic protease.

Verbascoside as a potential SGLT2 inhibitor in diabetic nephropathy: Targeting AMPK activation to suppress NOX4/NF-κB signaling and attenuate inflammation and fibrosis.

Verbascoside, a caffeoyl phenylethanoid glycoside is known to regulate diabetic conditions and its related complications as well as function as an anti-infective, immunosuppressive, and antioxidant agent. It is also an under investigational molecule for patients of IgA Nephropathy. However, its functions in diabetic nephropathy (DN) and underlying mechanisms remain unclear.

Phenotypic and molecular insights into a isolated from Helfer () and modelling of its polyhedrin protein structure.

Helfer () or Muga silkworm is popularly known for producing golden silk and endemic to the region of Northeast India. The present work characterizes a variant infecting larvae, exhibiting characteristic symptoms of flacherie disease. Scanning electron microscope and transmission electron microscope imaging revealed the presence of polyhedral occlusion bodies (OBs) and virion particles measuring 40-50 nm in size.