Standardising Simulation-Based Obstetric Emergency Training: A Delphi Consensus Study.

Objective: To develop standardised Objective Structured Assessment of Technical Skills (OSATS) forms for major obstetric emergencies, thereby improving the quality and consistency of obstetric simulation training.

Design And Setting: A panel of national experts with extensive experience in teaching Gynaecology and Obstetrics, simulation training, and the clinical management of labour complications and peripartum emergencies.

Population And Methods: A Delphi process with four iterative rounds was conducted to create, evaluate, revise, and finalise OSATS checklists for 11 obstetric emergencies.

ProMUS-NET: Artificial intelligence detects more prostate cancer than urologists on micro-ultrasonography.

Objectives: To improve sensitivity and inter-reader consistency of prostate cancer localisation on micro-ultrasonography (MUS) by developing a deep learning model for automatic cancer segmentation, and to compare model performance with that of expert urologists.

Patients And Methods: We performed an institutional review board-approved prospective collection of MUS images from patients undergoing magnetic resonance imaging (MRI)-ultrasonography fusion guided biopsy at a single institution. Patients underwent 14-core systematic biopsy and additional targeted sampling of suspicious MRI lesions.

Curriculum for optical diagnosis of esophageal neoplasia and precursor lesions: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement.

Pre-adoption: Endoscopists performing upper gastrointestinal (UGI) endoscopy should train to recognize the appearance of early esophageal cancer and its precursor lesions, for Barrett neoplasia and for squamous neoplasia, to improve detection rates.Every endoscopist should have achieved competency in UGI endoscopy before commencing training in optical diagnosis in the UGI tract, and this requires personal experience of 300 UGI endoscopies and meeting the ESGE quality measures for UGI endoscopy.

Training: Endoscopists should undertake interactive training courses to improve diagnostic accuracy for esophageal preneoplastic and neoplastic lesions.

Advances in the management of locally advanced rectal cancer: A shift toward a patient-centred approach to balance outcomes and quality of life.

The treatment of locally advanced rectal cancer (LARC) has undergone a significant evolution in recent years, shifting toward more selective strategies that balance oncological outcomes with quality of life (QoL) preservation. Total neoadjuvant treatment (TNT) has improved local control and reduced distant metastases, but its long-term toxicities have sparked growing interest in treatment de-escalation strategies aimed at minimizing adverse effects while maintaining efficacy. This review focuses on the therapeutic advancements for LARC, analysing both established standards and emerging innovations.

Adverse event profiles and management of cisplatin-based chemoradiotherapy in locally advanced head and neck squamous cell carcinoma: a systematic review.

Background: Patients with locally advanced squamous cell carcinoma of the head and neck (LA SCCHN) are treated with curative intent. Treatment guidelines recommend tumor resection, followed by adjuvant radiotherapy or chemoradiotherapy in patients with high risk of disease recurrence, or definitive chemoradiotherapy in patients who do not undergo surgery. When indicated, concurrent cisplatin provides benefit over radiotherapy alone but is highly toxic.

ESR Essentials: artificial intelligence in breast imaging-practice recommendations by the European Society of Breast Imaging.

Artificial intelligence (AI) can enhance the diagnostic performance of breast cancer imaging and improve workflow optimization, potentially mitigating excessive radiologist workload and suboptimal diagnostic accuracy. AI can also boost imaging capabilities through individual risk prediction, molecular subtyping, and neoadjuvant therapy response predictions. Evidence demonstrates AI's potential across multiple modalities.

Effectiveness of Biologic Therapy in Hidradenitis Suppurativa: Real-World Clinical Outcomes and Lipid Profile Evaluation.

Background: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with systemic implications. While biologic therapies have demonstrated efficacy in controlling cutaneous lesions, their systemic effects, particularly on lipid metabolism as a marker of systemic inflammation, are less understood.

Objectives: To evaluate the impact of biologic therapy on clinical severity and lipid profiles in HS patients in a real-world setting, comparing outcomes between Early and Late Responders at Week 24 ± 4.

The Influence of Radiographic Equipment, Setup, and Operator Experience on Radiation Exposure in Chronic Total Occlusion Interventions.

Background: High radiation exposure is a significant risk with recanalizations for chronic total coronary occlusions (CTO).

Aims: To analyze the influence of radiographic equipment, radiation protocols, and operator experience on radiation exposure.

Methods: We analyzed 17,769 procedures by 27 operators from a multicenter European Registry between 2015 and 2023.

Effect of SGLT2 inhibitors on cardiac structure and function assessed by cardiac magnetic resonance: a systematic review and meta-analysis.

Background And Aim: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) improve outcomes in patients with heart failure (HF) but underlying mechanisms remain incompletely understood. Cardiac magnetic resonance (CMR) is key in evaluating cardiac structure and function, enabling accurate assessment of reverse remodeling. Aim of this systematic review and meta-analysis was to assess the effects of SGLT2i on cardiac remodeling evaluated by CMR changes.

Controlled co-delivery of anti-inflammatory drugs from bilayer polymer films coating a meniscus implant.

Knee osteoarthritis (OA), a degenerative joint disease, is increasingly prevalent worldwide and often results from a meniscal deterioration that leads to meniscus removal. Replacing the damaged meniscus with a non-biodegradable prosthesis offers an innovative solution to prevent OA progression, particularly in older patients. However, the long-term use of anti-inflammatory drugs for pain relief and prosthesis integration can cause severe off-target side effects.

Robot-assisted radical nephroureterectomy for locally advanced upper tract urothelial carcinoma: a multicenter study by the Junior ERUS/YAU Working Group on Robot-assisted Surgery.

Introduction: Aim of the study was investigate outcomes of patients affected by locally advanced (pT3-pT4 and/or pN+) upper tract urothelial carcinoma (UTUC) and treated with robot-assisted radical nephroureterectomy (RNU).

Materials And Methods: Clinical and surgical data of newly-diagnosed UTUC patients referring to 9 high-volume centres from January 2019 to March 2023 undergoing RNU were collected.

Results: 191 patients showed locally advanced disease.

Spatial mapping of rheumatoid arthritis synovial niches reveals a LYVE1 macrophage network associated with response to therapy.

Objectives: Despite advances in rheumatoid arthritis (RA) treatment, a significant proportion of patients fail to achieve adequate remission. The dynamic cellular and architectural changes within the synovium that underpin therapeutic success remain poorly understood. This study aimed to unravel the synovial landscape during effective RA treatment, identifying key cellular networks and molecular pathways associated with remission.

Langerhans cell sarcoma is a clinically, biologically, and prognostically heterogeneous "malignant" histiocytosis: a systematic review of 88 cases from the literature.

Malignant histiocytoses are rare histiocytic neoplasms that exhibit aggressive clinical and histopathological features. One of these entities, Langerhans cell sarcomas (LCS), shares some histopathological features with Langerhans cell histiocytosis but is distinguished by its overtly malignant cytologic features. The literature on LCS is mostly limited to short reports and a few reviews, while a complete revision of its nosology is lacking.

Statistical Analysis in Allergy and Immunology: A Review With Practical Examples.

Statistical analysis plays a critical role in biomedical research, ensuring that data are interpreted appropriately and that conclusions are both valid and reproducible. In allergy and immunology, where studies increasingly rely on complex data structures and analytical approaches, clarity on biostatistical methods is essential to support transparency and scientific rigor. However, inconsistent statistical reporting and misuse of analytical techniques remain persistent challenges in the field.

Reflective Writing to Support Nursing Students' Ethical Understanding of End-of-Life Care: A Phenomenological Study.

End-of-life care requires nurses to integrate ethical sensitivity, emotional presence, and effective communication. Reflective writing, a key component of Narrative Medicine, offers nursing students a structured method to process complex emotional experiences and deepen their ethical understanding. This study investigated how third-year nursing students reflected on ethical issues and emotional responses related to end-of-life care through a structured reflective writing activity conducted after a film-based educational session.

Role of remdesivir for the treatment of COVID-19 in patients with hematologic malignancy-A narrative review and expert opinion.

Background: COVID-19 remains a potentially severe condition for immunocompromised individuals, such as patients with hematologic malignancy. These patients are at increased risk of progressing to severe-critical or prolonged COVID-19. Prompt treatment with antivirals has proven effective in preventing disease progression and is recommended by current guidelines.

Current practices and challenges in the management of cancer-associated thrombosis: a survey of Italian oncologists.

Purpose: This study investigates current practices and challenges in managing cancer-associated thrombosis (CAT) among Italian oncologists, with the objective of evaluating adherence to guidelines for primary thromboprophylaxis, treatment approaches, and safety considerations. Additionally, it aims to identify areas for potential improvement in clinical decision-making and standardization of CAT management.

Methods: A cross-sectional survey was conducted between February and June 2024 among Italian oncologists, facilitated by the Italian Network for Supportive Care in Oncology (NICSO).

Association of paramagnetic rim lesions with patient-reported neuropsychiatric symptoms in multiple sclerosis.

Background: Paramagnetic rim lesions (PRLs) mark chronic active lesions in multiple sclerosis (MS) and have been linked to disability progression and objective cognitive decline, but their relationship with invisible symptoms such as fatigue, mood disturbance and perceived cognition remains unclear.

Methods: We prospectively enrolled adults with MS who underwent 3T susceptibility-weighted imaging. Supratentorial PRLs were counted and participants were categorised into 0, 1-3 or > 3 PRLs.

Incidence, Risk Factors, and Management of Conjunctivitis in Atopic Dermatitis Patients Treated With Dupilumab or Tralokinumab: Results From a Multicenter, Observational, Retrospective Study.

Background: Conjunctivitis is among the most frequent adverse events (AEs) emerged in clinical trials for all biologic drugs approved for atopic dermatitis (AD). However, real-world comparative data on the incidence, risk factors, and management of conjunctivitis remain limited.

Objective: We aimed to compare the incidence, clinical features, and management of conjunctivitis in patients with moderate-to-severe AD treated with dupilumab or tralokinumab in a real-life setting.

STAndardization of Reports (the STAR project) Upper gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Quality Improvement Initiative.

Upper gastrointestinal (UGI) endoscopy is the mainstay for the diagnosis and staging of precancerous and cancerous conditions of the esophagus, stomach, and duodenum. Despite development of several validated classifications for UGI diseases, endoscopy reports differ between endoscopists and endoscopy departments. This document proposes a standardized high quality UGI endoscopy report, including preprocedural, periprocedural, endoscopic findings, and postprocedural information.