Harnessing Infrared Radiation: Transforming Vegetable Oil Quality, Drying Kinetics, and Bioactive Potential.

Infrared (IR) radiation, a versatile and efficient heating method, has garnered significant attention in the food and oil processing industries because of its unique heat transfer mechanism and broad range of applications. IR is applied in drying, peeling, decontamination, enzyme inactivation, and roasting, underscoring its potential for energy-efficient, high-quality processing. Its application to oil-bearing materials improves moisture removal rates and supports the preservation of critical quality parameters.

Solid Lipid Nanoparticles and Nanostructured Lipid Carriers for Anticancer Phytochemical Delivery: Advances, Challenges, and Future Prospects.

Phytochemicals exhibit a broad spectrum of pharmacological activities, including significant anticancer potential. However, their clinical translation is often hampered by poor aqueous solubility, low bioavailability, and chemical instability. Lipid-based nanocarriers, especially solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), have proven to be effective strategies for addressing these challenges.

Tubulin inhibitors: an insight into new strategies to combat leukemia.

Leukemia is a type of cancer that affects the blood and bone marrow and characterized by the uncontrolled production and accumulation of blood cells. According to the World Health Organization (WHO), leukemia is among the fifteen most commonly diagnosed cancers worldwide and the eleventh leading cause of mortality. Tyrosine kinase inhibitors are the first-line choice for the treatment of acute or chronic leukemia.

Modulation of Nrf-2/HO-1/HIF-1α/TFAM pathways by Arbutin in rat model of cerebral ischemic stroke.

Ischemic stroke (IS) reduces the blood flow to the brain regions that trigger oxidative stress-induced biochemical, behavioural, molecular, and cellular impairments. Current treatment strategies are limited due to their narrow therapeutic window as, there is an urgent need to identify alternative therapeutic strategies in clinical settings to promote beneficial outcomes in stroke patients. Current study, focused on the neuro-protective potential of Arbutin (AR) in ischemic brain injury via modulation in Nrf-2/HO-1/HIF-1α/TFAM pathway.

Role of diosgenin in gastrointestinal cancers: recent trends and future perspectives.

Gastrointestinal cancers represent a considerable global public health burden, due to their high incidence, poor prognosis, and resistance to conventional therapies. Traditional treatments like chemotherapy and radiation often produce side effects and limited efficacy, making targeted therapies even more necessary. Diosgenin, a naturally steroidal saponin found in Dioscorea species, has gained widespread acclaim as an anticancer agent due to its anti-inflammatory, antioxidant, and cancer-fighting properties.

Optimisation of Ultrasound-Assisted Extraction Conditions Using Response Surface Methodology and Identification of Thymoquinone from Black Cumin ( L.) Seed Extract.

Research Background: L., commonly known as black cumin, is a medicinal plant renowned for its rich bioactive composition and health-promoting properties. Among its key compounds, thymoquinone has gained significant attention in nutraceutical and pharmaceutical research for its potential to prevent and manage chronic inflammatory conditions and immune dysfunctions.

Neuroprotective Role of Eupalitin in Streptozotocin-Induced Diabetic Rats: In Silico and In Vivo Studies.

Alzheimer's disease (AD) is a neurodegenerative condition with marked cognitive loss and impaired thinking abilities as well as spatial memory, working memory, and communication skills. Numerous studies have found that both type 1 and type 2 diabetes lead to neuropathological and neurobehavioral problems, which lead to notable cognitive dysfunction and deterioration in memory. The aims of this study are to find out the neuroprotective potential of eupalitin on memory in streptozotocin-induced diabetic rats and to evaluate its binding affinity on acetylcholinesterase by using molecular docking studies.

Recent Advances in dehydroacetic acid-clubbed pyridine conjugates: design, synthesis, characterization, molecular docking investigations and evaluation of anti-cancer efficacy.

Aim: The aim of this study was to synthesize novel pyridine conjugates incorporating dehydroacetic acid via the Krohnke reaction and to evaluate their potential as anti-cancer agents. Materials & methods: The Krohnke reaction has previously been reported using acetic acid as the solvent, here we employed ethanol as the reaction medium. The trisubstituted pyridine derivatives were synthesized via a multistep procedure that involved the reaction of pyridinium bromide salts with chalcone derivatives of dehydroacetic acid.

Impact of Growth-Promoting Endophytic Bacteria on Ginger Plant Growth.

Phytohormones has produced by endophytic bacteria promote the development and yield in plants. To investigate the role of endophytic bacteria on the soil properties and the growth of ginger, a net house experiment was carried. The experiment was used four treatments (Control, IGPEB 34, IGPEB 37, and IGPEB 20).

Biotic Stress Alleviation in Plant Using Rhizobacteria: An Overview of Mechanism of Action, Antimicrobial Compounds Production, (Nano) Formulations and Employment Methods.

The biotic stress induced by phytopathogens causes a significant loss to several crops in terms of yield and quality. Biotic stress may disrupt phenotypic characteristics and alter metabolic pathways in plants. Sustainable approaches like the employment of rhizobacteria control phytopathogens and diseases thereof through production of antimicrobial compounds and boosting plant defense systems.

A momentous progress update: epidermal growth factor receptor inhibitors as viable agents for combating cancer.

The epidermal growth factor receptor (EGFR) family comprises four distinct members with similar framework characteristics: EGFR (HER1/ErbB1), ErbB2 (HER2/neu), ErbB3 (HER3), and ErbB4 (HER4). EGFR plays a pivotal role in cellular signaling pathways that regulate key pathological processes, including apoptosis, uncontrolled cell proliferation, metastasis, and angiogenesis. However, clinically used EGFRs such as apatinib, selumetinib, gefitinib, vandetanib, and erlotinib are not selective, thereby resulting in troublesome side effects.

Synthesis of novel trans-2,3-dihydrofuran-pyrazole conjugates through molecular hybridization: molecular docking insights and evaluation of anti-inflammatory and anti-malarial activities.

A series of some new trans 2,3-dihydrofuran-linked pyrazole hybrids were synthesized from a convenient one-pot methodology. This procedure employs a sequential one-pot, two-step tandem reaction starting from pyridine, formylpyrazole, dimedone, and phenacyl bromide, with triethylamine serving as the base and proceeds efficiently in acetonitrile. The recently synthesized compounds were characterized through H and C NMR, Mass and IR spectroscopy and evaluated for their anti-inflammatory and anti-malarial potentials.

Gliadin Encapsulated Procyanidolic Oligomers Nanoformulation: Aggrandized Antimicrobial, Antioxidant as Well as Anticancer Potential Makes it an Effective Therapeutic Modality for Lung Carcinoma.

Lung cancer is responsible for highest mortality rates among both men and women globally. There is a need of effective and safe treatment modality that specifically targets cancer cells and doesn't not harm healthy cells. Procyanidolic oligomers (PCOs) is a natural antioxidant found in grape seed, acts as medicament for the treatment of various disease which are linked with oxidative stress specifically cancer.

A Novel Electrochemical Sensing Platform for Detection of Nitrobenzene Using Gadolinium Oxide Nanorods Modified Gold Electrode.

Unlabelled: In the present study, hydrothermally prepared, one-dimensional gadolinium oxide (GdO) nanorods were utilized to modify the gold electrode (AuE) for the fabrication of GdO/AuE sensor. The nanorod-modified electrode was employed for the sensitive and selective detection of nitrobenzene. The material serves as a highly active electrode material due to its many active sites, high electrocatalytic efficiency, and fast kinetics lead to superior sensing capabilities.

Nanocomposite Foils of PS/Cu : Dual Functionality of Optical Enhancement and Antibacterial Activity on .

Copper nanoparticles embedded in polystyrene (PS) nanocomposite foils were prepared via the solution casting method to study their optical characteristics and antimicrobial activities. Structural and surface morphology of the prepared nanocomposite foils were carried out by FTIR and FESEM. UV-vis spectra reveal that the nanocomposite foils are optically transparent in the visible region, with a strong absorbance peak at ~ 264 nm.

Nanotechnology-Based Modern Biosensors for the Detection of SARS-CoV-2 Virus.

The emergence of the COVID-19 pandemic has pointed out the urgent need for rapid and accurate diagnostic tools to detect the SARS-CoV-2 virus. Nanotechnology-based biosensors have emerged as a promising solution due to their high sensitivity, specificity, and speed in detecting biological molecules. This article focuses on the advancements in using nanotechnology for the development of modern biosensors tailored for the detection of the SARS-CoV-2 virus.

Bionanotechnology: A Paradigm for Advancing Environmental Sustainability.

The urgent need for innovative solutions to global environmental challenges has driven the convergence of biology and nanotechnology, resulting in the emergence of bionanotechnology as a transformative force. This comprehensive review paper explores the fundamental principles, applications, benefits, and potential risks associated with harnessing bionanotechnology to advance environmental sustainability. Beginning with an elucidation of the fundamental concepts underlying bionanotechnology, this paper establishes the synergy between biological systems and nanomaterials.

Insights into the molecular mechanisms underlying phthalates-induced nephrotoxicity.

Phthalates are the most common environmental toxicantsthat are added to plastics to improve their elasticity and extensibility. Different products such as baby toys, personalcare products, packaging materials and pharmaceutical products contain various phthalates like Di-(2-ethylhexyl) phthalate (DEHP), Dibutyl phthalate (DBP), etc. During processing, transportation and preparation, these phthalates can leach out into food anddrinks.

Innovative use of immobilized zinc oxide-impregnated activated carbon (ZnO@CB) for effective treatment of leachate: modeling and predictive assessment.

This study examined the viability of column method utilizing the immobilized zinc oxide-loaded activated carbon obtained from corncob (ZnO@CB) to treat the landfill leachate. Instrumental techniques like BET, FTIR, SEM-EDX, and XRD were applied for the characterization of the adsorbents. The break through curve (BTC) was evaluated by altering the flow rate, bed height, and initial concentration of NH-N and COD.

Nanoarchitectonics in colloidal hydrogels: Design and applications in the environmental and biomedical fields.

The concept of nanoarchitectonics, derived from the science of nanoarchitecture, has driven the development of advanced colloidal hydrogels with enhanced functionalities for a wide range of applications. This review explores technological perspectives of nanoarchitectonics, especially in regard to colloidal hydrogels. Nanoarchitectonics applied to colloidal hydrogels allows nanoscale control over the structure and functionality of hydrogels to impart dynamic properties such as stimuli-responsiveness, controlled release, and enhanced mechanical strength.

Vesicular Carriers for Phytochemical Delivery: A Comprehensive Review of Techniques and Applications.

Natural substances, especially those derived from plants, exhibit a diverse range of therapeutic benefits, such as antioxidant, anti-inflammatory, anticancer, and antimicrobial effects. Nevertheless, their use in clinical settings is frequently impeded by inadequate solubility, limited bioavailability, and instability. Nanovesicular carriers, such as liposomes, niosomes, ethosomes, transferosomes, transethosomes, and cubosomes, have emerged as innovative phytochemical delivery systems to address these limitations.

Biomaterials for eco-friendly packaging in dairy products: towards a cleaner, greener, and sustainable future.

Milk and milk products are very susceptible to spoilage and therefore, suitable innovative packaging strategies are indispensable to enhance shelf life along with maintaining quality and safety. Transformation in the utilization of packaging materials and technologies in the dairy sector is trending to match and meet the changing demands of consumers aware of this. Smart, intelligent, and active packagings are a few innovative packaging strategies that aim at protracting the shelf stability of milk and milk products while enhancing safety and sensory qualities.

Optimisation of process parameters for lignocellulosic biomass degradation by Pseudomonas sp. using response surface methodology.

Globally, over 5 billion tons of crop residue are produced annually, contributing to pollution and soil degradation. That's why this study used response surface methodology to biodegrade rice straw (R.S.