Correction: α-Mangostin alleviated inflammation in rats with adjuvant-induced arthritis by disrupting adipocytes-mediated metabolism-immune feedback.

[This corrects the article DOI: 10.3389/fphar.2021.

Agrochemical fungicides as environmental drivers of antifungal resistance.

Once neglected, the debate on antifungal drug resistance has increased due to the emergence of antifungal resistant strains. Several factors are associated with the increase in resistance rates, and the use of fungicides in agricultural practice is probably an important cause. This review aimed to summarize studies performed with fungicides, which could show the correlation between the use of these agrochemicals and the development of cross-resistance to clinical antifungals in human/animal pathogenic fungi.

Extent of Surgical Resection and Predictors of Outcomes in MEN1-Related Hyperparathyroidism: A Systematic Review and Meta-Analysis.

Context: Primary hyperparathyroidism (PHPT) is the earliest and most frequent manifestation of multiple endocrine neoplasia type 1 (MEN1). The optimal surgical extent remains controversial due to the trade-off between recurrence and permanent hypoparathyroidism.

Objective: To evaluate outcomes of different surgical approaches in MEN1-related PHPT and assess preoperative biochemical predictors through systematic review and meta-analysis.

High-Resolution aCGH Analysis of the Jurkat Cell Line: Copy Number Alterations and Their Association With Cancer Hallmarks.

Background/aim: Cell lines serve as valuable models to study altered cellular signaling pathways, to identify mutations in key oncogenic genes, and to test potential antitumor drugs. The Jurkat cell line, for example, has provided important information about various signaling pathways in lymphoblastic leukemia, establishing most of what is currently known about T-cell receptor (TCR) signaling. However, many aspects of the genome modification of this cell line have not yet been analyzed.

Integrative behavior analysis, oxidative stress markers determination and molecular docking to investigate proconvulsant action of betalactamic carbapenems.

Carbapenems are broad-spectrum β-lactam antibiotics widely used in critical and hospitalized patients. They are usually well tolerated; however, under certain conditions, these drugs are associated with central nervous system toxicity and proconvulsant activity. Here, we investigated the proconvulsant action of different generation carbapenems: imipenem (IMI), meropenem (MERO), and ertapenem (ERTA) in mice through behavioral analysis.

Blood-based biomarkers of neuroaxonal and astroglial injury identify ultra-treatment-resistant schizophrenia.

Background: Ultra-treatment-resistant schizophrenia (UTRS) is the most severe subtype of treatment refractoriness, with persistent symptoms despite clozapine use. Although immunoinflammatory mechanisms have been implicated in schizophrenia, the biological basis of UTRS remains unclear. We hypothesized that blood-based biomarkers of astroglial and neuroaxonal injury could distinguish UTRS from other schizophrenia subtypes and healthy controls.

Targeting the Dectin-1 Receptor in Neuroinflammation: Therapeutic Implications for Neuropsychiatric Disorders.

Exploring the role of the pattern recognition receptor Dectin-1 in neurological diseases emerges as an important target for understanding the biochemical and physiological dynamics of neuropathologies. From this perspective, Dectin-1, protein encoded by the CLEC7A gene, stands out for its important role in antifungal immunity; however, the receptor also proves crucial in enabling the immune response of the central nervous system (CNS). This review highlights how Dectin-1 interacts with microglial cells, as well as the implications of these interactions in inflammatory, neurodegenerative, and psychiatric processes.

Synergistic Effect of Antimicrobial Resistance and Cytogenetic Risk on Mortality in Acute Myeloid Leukemia.

Background/aim: Acute myeloid leukemia (AML) is an aggressive hematological malignancy requiring intensive chemotherapy, which induces profound immunosuppression. Multidrug-resistant Gram-negative (MDRGN) bacterial colonization and infection are an emerging challenge in AML management, potentially worsening survival outcomes. This retrospective single-center cohort study evaluated the impact of MDRGN colonization and infection on overall survival (OS) in patients with AML undergoing chemotherapy.

Evaluation of the Circadian Rhythm Component Cipc (Clock-Interacting Pacemaker) in Leukemogenesis: A Literature Review and Bioinformatics Approach.

Circadian rhythms (CRs) are a key biological system regulating physiological processes such as metabolism, cell growth, DNA repair, and immunity, adapting to environmental changes like the light/dark cycle. Governed by internal clocks, it modulates gene expression through feedback loops involving Clock Genes (CGs), with the cycle initiated by CLOCK-BMAL1 and NPAS2-BMAL1 heterodimers. Disruptions in circadian rhythms have been linked to diseases including metabolic disorders, neurodegeneration, and cancer.

Clinical Significance and Prognostic Value of TLR4 and AGER in Inflammatory Breast Cancer.

: Inflammatory breast carcinoma (IBC) is an aggressive and rare neoplasm, accounting for 1-5% of all breast cancers. Toll-like receptor type 4 (TLR4) and Advanced Glycation End Products Receptor (AGER/RAGE) have been implicated in breast cancer, and have been shown to promote tumor growth, metastasis, and resistance to therapy by modulating the tumor microenvironment and inflammatory pathways. However, the role of TLR4 and AGER in IBC has not been elucidated.

Predicting Quality Markers of Xuefu Zhuyu Wan for Postoperative Cognitive Dysfunction Using Integrated LC-MS Analysis and Network Pharmacology.

The study aims to analyze the chemical constituents of Xuefu Zhuyu Wan (XZW) based on LC-MS and explore the mechanism of XZW in treating postoperative cognitive dysfunction (POCD) through network pharmacology and identify its potential quality marker (Q-marker). The chemical components of XZW were analyzed by LC-MS, and the corresponding targets were predicted by SwissTargetPrediction. Then POCD targets were obtained by GeneCards, OMIM, PharmGKB, and TTD database, and the "components-targets" and protein-protein interaction (PPI) maps were drawn by Cytoscape 3.

Research on the Influence of Orthogonal Design Optimized Elicitor Combinations on Fucoxanthin Accumulation in and Its Expression Regulation.

Fucoxanthin, a carotenoid with notable pharmaceutical potential, has attracted significant attention due to its efficient accumulation in marine microalgae and the importance of optimizing its induction conditions. In this study, was employed as a model organism to screen optimal conditions for fucoxanthin accumulation using a three-factor, four-level orthogonal design. Furthermore, the underlying mechanisms related to photosynthetic physiology and gene regulation were explored.

Cord blood cytokines/chemokines linked to delays in toddlers exposed to SARS-CoV-2 prenatally.

Background: Maternal infections are linked to neurodevelopmental impairments, highlighting the need to investigate SARS-CoV-2-induced immune activation.

Objective: This study aimed to evaluate the impact of maternal infection on neurodevelopment and investigate whether cytokine and chemokine profiles predict delays at 24 months.

Methods: Conducted in Brazil (January 2021-March 2022), this follow-up study included 18 SARS-CoV-2 positive pregnant women at 35-37 weeks' gestation, 15 umbilical cord blood samples, and blood samples from 15 children at 6 months and 14 at 24 months.

Alpha-lipoic acid as a modulator of healing in an animal model of pressure injury: Inflammatory implications and its relationship with depressive disorders.

This study evaluated the wound-healing effects of topical alpha-lipoic acid (ALA) in a mice pressure injury (PI) model and its association with behavioral and neurochemical alterations. Male Swiss mice (25-30 g) were assigned to control, SHAM, base cream, ALA cream, or alginate hydrogel groups. PI was induced through a 4-day ischemia/reperfusion protocol, followed by 10 days of treatment.

Effect of 5-fluorouracil on Escherichia coli and Enterococcus spp.: insights into the selective pressures caused by this cytotoxic drug.

5-Fluorouracil (5-FU) is a chemotherapeutic agent that disrupts pyrimidine metabolism, which can interact with gut microbiota, potentially causing dysbiosis and promoting antibiotic resistance. This study analyzed its antimicrobial and antibiofilm effects on Escherichia coli and Enterococcus spp. The Minimum Inhibitory Concentrations (MIC) and Minimum Biofilm Eradication Concentrations (MBEC) of 5-FU were determined against 17 clinical isolates, including resistant and susceptible strains.

What Can Proteomics Tell us About COVID-19 Infections? Mass Spectrometry as a Tool to Find New Proteins as Biomarkers.

The COVID-19 outbreak, caused by the SARS-CoV-2 coronavirus, has threatened and taken many lives since the end of 2019. Given the importance of COVID-19 worldwide, since its spread, many research groups have been seeking blood markers that could help to understand the disease establishment and prognosis. Usually, those markers are proteins with a differential accumulation only during infection.

Analgesic and neuroprotective effect of a lipid transfer protein isolated from Morinda citrifolia L. (noni) seeds on oxaliplatin-induced peripheral sensory neuropathy in mice.

Oxaliplatin, a 3rd-generation platinum compound, has a dose-limiting effect: neurotoxicity manifests as peripheral sensory neuropathy (PNS). Many studies have assessed the different pharmacological properties of a lipid transfer protein isolated from Morinda citrifolia L. (McLTP) seeds.

QKCMP peptide carrier macromolecule structure and release system based on triangular DNA origami nanostructures: A novel strategy for promoting angiogenesis.

In recent years, the use of nanocarriers to deliver bioactive peptides has become a new strategy to promote angiogenesis. The aim of this study was to develop a QKCMP peptide delivery system based on triangular DNA origami nanostructure (tDONs) carrier to improve the bioactivity and targeting of the peptide. The main objective of this study was to design and prepare QKCMP peptide-TDOns complexes and to evaluate their angiogenesis promoting effects in vitro and in vivo.

Biological activities of acanthoic acid and its pharmacological potential: a literature review.

Plant-derived compounds can influence human physiology and have been harnessed through infusions and teas, which addressed human health since prehistory. Thus, acanthoic acid is a natural pimaradiene diterpene found in species of the Annonaceae family. This botanical family includes fruit-bearing trees such as cherimoyas, custard apples, soursops, and rollinia, popularly using these species for antiparasitic, anti-leishmanial, antimicrobial, cytotoxic, and antioxidant purposes.

Extraction, purification, physicochemical properties, and spectroscopic stability of the R-Phycoerythrin from the seaweed Solieria filiformis cultivated in Ceara Coast/Brazil.

R-Phycoerythrin (R-PE) is a phycobiliprotein belonging to photosynthetic system of red seaweeds, which has a wide application in biotechnological and industrial products due to its antioxidant and spectroscopic properties. New renewable and sustainable sources of this pigment are still underreported. Therefore, this study aimed to extract, purify, and characterize the physicochemical properties of the R-PE from the red seaweed Solieria filiformis cultivated in the sea of Brazil Northeast.

Maternal Immunization Against SARS-CoV-2 and Infant Immunity Persistence in a Brazilian Cohort.

From January 2021 to March 2022, we studied antibody transfer and persistence in infants of SARS-CoV-2-infected or vaccinated pregnant women in Brazil. Third-trimester vaccination increased maternal anti-S immunoglobulin G, correlating with cord and infant levels at 6 months. Neutralizing antibody were detected only in vaccinated mothers and cord blood, persisting in only 2 infants at 6 months.

Development of a Peptide-Based Multiepitope Vaccine from the SARS-CoV-2 Spike Protein for Targeted Immune Response Against COVID-19.

Background: Since the Coronavirus Disease (COVID-19) became a pandemic in late 2019, vaccination remains the primary approach to combating the virus. Nevertheless, the emergence of new variants poses challenges to vaccine efficacy. This study aimed to identify targets within the SARS-CoV-2 spike (S) protein to detect T-cell responses to the five variants of concern from SARS-CoV-2: Alpha, Beta, Delta, Gamma, and Omicron.

3-(3-(diethylamino)propyl)-2-(4-(methylthio)phenyl)thiazolidin-4-one Attenuates Scopolamine-induced Cognitive Impairment in Rats: Insights Into Neuroprotective Effects.

Alzheimer's Disease (AD) is characterized by memory decline, dysregulation in cholinergic and purinergic signaling, neuroinflammation, and oxidative stress. Current treatments are limited, highlighting the need for new compounds to prevent or delay AD progression. Thiazolidinones have emerged as promising candidates due to their antioxidant, anti-inflammatory, and anticholinesterase properties.