Relationship of vitamin D receptor expression with hormone receptors and other clinicopathological features in primary breast carcinomas: A retrospective cross-sectional study.

Breast cancer is a heterogeneous disease in which estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 play crucial roles in molecular subtyping, diagnosis, treatment, and prognosis, showing positivity in nearly 90% of cases. The vitamin D receptor (VDR) has been implicated in the oncogenesis and prognosis of various tumors, but its relationship with molecular subtyping factors in breast carcinomas remains to be clarified. This retrospective cross-sectional study included 111 patients who underwent surgery for breast carcinoma.

Rare Acute Polyarticular Gout Disease Detected with F-FDG PET/CT.

Gout is an inflammatory arthropathy that develops due to the accumulation of monosodium urate crystals in the joints in adults. In approximately half of the cases, it presents as monoarthritis with an acute attack involving the first metatarsophalangeal joint. The first attack is rarely polyarticular.

Analysis of Imaging Findings in a Patient with Squamous Cell Carcinoma of the External Auditory Canal Metastatic to the Dura with Trigeminal Nerve Involvement.

We report the case of a 56-year-old female recently diagnosed with well-differentiated squamous cell carcinoma of the external auditory canal. The patient underwent an 18F-fluorodeoxyglucose positron emission tomography/computed tomography for staging assessment. This examination revealed intense uptake in the right ear canals, tympanic cavity, eustachian canal, parapharyngeal area, and infratemporal fossa.

CD105 (Endoglin) Expression as a Prognostic Marker in Aggressive Papillary Thyroid Carcinoma.

Background: Papillary thyroid carcinoma (PTC) is the most common type of thyroid malignancy, with a generally favourable prognosis. However, a subset of PTC cases exhibit aggressive behaviour, including lymph node and distant organ metastases. Identifying biomarkers that can differentiate between benign and malignant lesions, as well as predict tumour aggressiveness, is crucial for improving diagnosis and management.

Incidentally Detected High-Grade Follicular Derived Non-Anaplastic Thyroid Carcinoma on Ga-PSMA PET-CT.

Ga--prostate-specific membrane antigen (PSMA)-11 positron emission tomography/computed tomography (PET/CT) is currently routinely used for the evaluation of prostate cancer. However, due to its whole-body imaging capability, it can incidentally identify pathologies beyond prostate cancer. Herein, we describe a case of a 67-year-old man who was recently diagnosed with prostate carcinoma (PCa).

Investigation of Keratinized Squamous Epithelium from Mastoid Cortical Bone Dust in Patients with or without Cholesteatoma.

Objective: This study aimed to investigate squamous metaplasia in mastoid cells of patients undergoing surgery for chronic otitis media (COM) with or without cholesteatoma. Bone dust was stained with hematoxylin and eosin (H&E) for squamous cells and keratin and immunohistochemically for p63. Additionally, the feasibility of routine pathological examination of bone dust via H&E staining was evaluated for cost-effectiveness and for identifying patient groups needing advanced follow-up.

Clinical Characteristics of Nail Unit Melanoma in Türkiye: The Experience of Two Tertiary Dermatology Centers.

Background: The literature on the clinical presentations of nail unit melanoma (NUM) in different countries is limited.

Aims: To assess the specific clinical characteristics of NUM in Türkiye.

Study Design: A retrospective cross sectional study.

Impact of Ga-FAPi PET/CT on Staging or Restaging Digestive System Tumors in Patients with Negative or Equivocal F-FDG PET/CT Findings.

Objectives: This study aimed to evaluate the potential efficacy of Ga-fibroblast activation protein inhibitor (FAPi) positron emission tomography/computed tomography (PET/CT) for detecting, staging, and restaging digestive system malignancies that are F-fluorodeoxyglucose (F-FDG) negative or show equivocal F-FDG uptake.

Methods: We conducted a prospective analysis of 30 patients with pathologically confirmed primary tumors or metastases of the digestive system. Participants underwent Ga-FAPi PET/CT and F-FDG PET/CT imaging for staging or restaging purposes within the same week.

The Effect of St. John's Wort Oil on Urethral Stricture: An Experimental Study in Rat Model.

Objective: The aim was to evaluate the effect of yellow and red centaury St. John's Wort (St. JW) oil on inflammation and urethral fibrosis development in a rat urethral trauma model.

Acrodermatitis dysmetabolica: lessons from two pediatric cases.

Objectives: Acrodermatitis dysmetabolica (AD) is a dermatologic manifestation associated with inherited metabolic disorders (IMDs), distinct from acrodermatitis enteropathica, which occurs solely due to zinc deficiency.

Case Presentation: This report presents two pediatric cases: a 30-month-old girl with maple syrup urine disease (MSUD) experiencing AD secondary to severe isoleucine deficiency due to a protein-restricted diet, showing improvement with dietary adjustments, and a 2.5-month-old boy infant with propionic acidemia (PA) who developed AD alongside septic shock, which progressed despite intervention.

Management of Orbital Granulomatous Polyangiitis Presenting with Lacrimal Gland Involvement: Treatment of Subsequent Peripheral Ulcerative Keratitis, Anterior Uveitis, and Exudative Retinal Detachment in a Challenging Case.

This case report discusses a case of granulomatosis with polyangiitis (GPA) initially presenting with lacrimal gland involvement and subsequently developing additional features. GPA is a disease known for inflammation in the respiratory tract and kidneys. A 63-year-old male patient presented with a mass, swelling, and ptosis in the right upper eyelid.

Juvenile papillomatosis: A case report.

Juvenile papillomatosis (JP) is a very rare benign proliferative breast disease, especially in young women under 30 years of age. Its etiology is not clear yet. Although some patients have breast cancer in their family history, up to 10% breast cancer can develop in the follow-up of JP patients.

GATA3 Immunohistochemical Staining in Classical Hodgkin Lymphoma and Its Diagnostic Utility in Differential Diagnosis.

Objective: Classical Hodgkin lymphoma (CHL) is a common lymphoid neoplasm with a wide range of differential diagnoses. Although it has a specific immunophenotype, aberrant expression of antigens can cause problems at its diagnosis. In this study we evaluated the usefulness of GATA3 in the differential diagnosis of CHL.

Evaluation of CD56 and CD117 Double-Positivity as a Predictor of Poor Prognosis in Multiple Myeloma Patients: A Retrospective Analysis.

Objective: Despite advancements in treatment, multiple myeloma (MM) remains a challenging hematologic malignancy. It is crucial to stratify risk and perform prognostic assessment with various markers, including the expression of cluster of differentiation 56 (CD56) and cluster of differentiation 117 (CD117). However, the relationship of these markers with MM-related survival remains unclear.

The relationship between URG4 and clinicopathologic parameters and its effect on two-year survival in gastric carcinoma.

Aim: Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. The present study examined the relationship between Upregulated gene 4 (URG4) expression, an oncogene involved in the development of gastric carcinoma, and clinicopathologic parameters including Human epidermal growth factor receptor 2 (HER2) status. The study aimed to investigate the importance of URG4 as a prognostic factor for 2-year survival in GCs, which are usually in the advanced stage at the time of diagnosis and have a rapid course.

Cerium oxide nanoparticles (nanoceria) pretreatment attenuates cell death in the hippocampus and cognitive dysfunction due to repeated isoflurane anesthesia in newborn rats.

General anesthetics exposure, particularly prolonged or repeated exposure, is a crucial cause of neurological injuries. Notably, isoflurane (ISO), used in pediatric anesthesia practice, is toxic to the developing brain. The relatively weak antioxidant system at early ages needs antioxidant support to protect the brain against anesthesia.

Musinous cystic neoplasia mimicking hydatid cyst in the liver: Two rare cases.

Mucinous cystic neoplasm of the liver (MCN-L) is a rare tumor which accounts for less than 5% of all liver cysts. Although they are considered to be "benign cysts" radiologically and clinically because of their slow growth, they are considered as premalignant. We present two radiologically misdiagnosed cases that operated in a short time range, in order to increase awareness for these rare tumors.

Do HPV 16 positive/ASC-H cervical cancer screening results predict CIN 2+ better than other high-risk HPV subtypes?

Objective: To determine whether patients with atypical squamous cells, cannot exclude high grade squamous intraepithelial neoplasia (ASC-H) cytology have a correlation between high-risk human papillomavirus (HPV) type and CIN 2+ lesion in final pathology.

Material And Methods: The study was conducted retrospectively, using data from three tertiary gynecologic oncology centers located in various regions of Turkey. Data from 5,271 patients who had colposcopy between January 2003 and January 2021 were analyzed.

Comparative study of virus and lymphocyte distribution with clinical data suggests early high dose immunosuppression as potential key factor for the therapy of patients with BoDV-1 infection.

Borna disease virus 1 (BoDV-1) was just recently shown to cause predominantly fatal encephalitis in humans. Despite its rarity, bornavirus encephalitis (BVE) can be considered a model disease for encephalitic infections caused by neurotropic viruses and understanding its pathomechanism is of utmost relevance. Aim of this study was to compare the extent and distribution pattern of cerebral inflammation with the clinical course of disease, and individual therapeutic procedures.