BSND: An emerging immunohistochemical marker that reliably distinguishes benign from malignant oncocytic salivary gland tumors.

Oncocytic cells appear in various salivary gland lesions (SGLs) like oncocytic hyperplasia, metaplasia and several neoplasms. It is particularly challenging to distinguish oncocytoma and Warthin tumor from oncocytic and Warthin-like mucoepidermoid carcinoma (MEC) in the absence of molecular testing. A spectrum of oncocytic SGLs underwent immunohistochemistry for BSND, a novel marker of striated ducts and oncocytic tumor cells.

Multiparametric MRI in Diagnosis of Parotid Gland Tumor: An Observational Study in 3-T MRI.

 Preoperative magnetic resonance imaging (MRI) has an important role in the management and prognostication of parotid gland tumors. We aim to evaluate the role of multiparametric MRI in differentiating the major subgroup of parotid tumors.  Multiparametric MRI: T1-weighted imaging (T1WI), T2WI, diffusion-weighted imaging (DWI), pseudo-continuous arterial spin labeling (ASL) and dynamic contrast-enhanced (DCE) imaging were acquired in all patients.

Incidentally Detected High-Grade Follicular Derived Non-Anaplastic Thyroid Carcinoma on Ga-PSMA PET-CT.

Ga--prostate-specific membrane antigen (PSMA)-11 positron emission tomography/computed tomography (PET/CT) is currently routinely used for the evaluation of prostate cancer. However, due to its whole-body imaging capability, it can incidentally identify pathologies beyond prostate cancer. Herein, we describe a case of a 67-year-old man who was recently diagnosed with prostate carcinoma (PCa).

Mammary Analogue Secretory Carcinoma of the Parotid at Younger Age: An Unusual Entity.

Introduction: Malignancy of parotid glands is uncommon in the pediatric age group. Among the various subtypes, mammary analogue secretory carcinoma (MASC) of parotid is an unusual variant that mimics pathologically those of mammary secretory carcinoma of the breast. It usually presents as a slow-growing, painless parotid mass.

Assessment of Risk of Malignancy by Application of the Proposed IAC-IARC-WHO Cytopathology System for Classification and Reporting of Soft Tissue Lesions: An Experience From Tertiary Care Center From India.

Introduction: Soft tissue lesions encompass a diverse category of diseases from benign to malignant, and their morphology might overlap; therefore, accurate categorization is needed to approach the reporting of soft tissue cytology. The cytology of these lesions is helpful in detecting the features of malignancy, which helps in guiding further management. In this study, we applied the proposed IAC-IARC-WHO cytopathology system to assess the risk of malignancy (ROM) and diagnostic accuracy (DA) for the determination of its clinical and diagnostic utility.

Assessment of risk of malignancy with application of Sydney classification for reporting of lymph node cytopathology in pediatric population: An institutional experience.

Background: Fine-needle aspiration cytology (FNAC) has been used as the first line approach to lymphadenopathy, which is a common presentation in pediatric age group. The Sydney system for reporting of lymph node (LN) cytology has been proposed to assess the reliability, performance, and accuracy of the aspiration procedure. This study intends to assess the role of FNAC in the pediatric population according to the Sydney system.

Cytology of an Axillary Mass: A Rare Case.

This is an interesting case of rhabdomyosarcoma, presenting at an unusual site and diagnosed on FNAC. The smears depict the typical malignant small round cell morphology and tigroid background. It illustrates the role of cell block and immunohistochemistry as important ancillary adjuncts to morphology.

Warthin-like Papillary Thyroid Carcinoma: A Case Report and Review of the Literature.

Warthin-like subtype of papillary thyroid carcinoma (WLPTC) is a rare subtype of papillary thyroid carcinoma. This PTC subtype shows some pattern resemblance to Warthin tumors of the salivary gland, which confers its name but is a not genetically similar to salivary Warthin tumor, with the most frequent genetic change in WLPTC being BRAF p.V600E, the most frequent genetic driver of PTC.

Correlation of Narrow Band Imaging Patterns with Histopathology Reports in Head and Neck Lesions.

Introduction: Head and neck malignancies are associated with poor prognosis and poor quality-of-life if detected late. Narrow-Band-Imaging(NBI) is one of the important tools, which helps in detecting these lesions earlier. By using narrow-wavelength(400-550 nm) it enhances the mucosal and submucosal vascularity against the pale mucosal background which helps us detecting benign, pre-malignant and malignant lesions.

Metastatic Renal Cell Carcinoma Masquerading as a Laryngeal Tumor: A Case Report.

Renal cell carcinoma (RCC) commonly metastasizes to various organs such as the lungs, liver, bones, and brain. However, isolated metastases to the head and neck region, especially the larynx, are very rare. This report presents a case of laryngeal growth that was eventually confirmed to be a metastatic deposit from an undiagnosed RCC.

Carotid Body Tumors: Institutional Experience of 10 Cases and a Review of Literature.

Carotid body tumors are slow growing neck masses that arise from the neural crest cells at the carotid bifurcation. Majority are asymptomatic and are diagnosed incidentally. Surgical excision is accepted as the treatment of choice to reduce complications.

A rare maxillofacial manifestation of acute lymphoblastic leukemia in a 9-year-old child.

Acute lymphoblastic leukemia (ALL) is considered as the most common malignant neoplasm of childhood and the frequent cause of death from cancer before 20-years of age. The facial swelling mimicking a maxillofacial tumor is rarely associated with ALL. Clinicians should be aware of such rare manifestation of ALL.

An Incidentally Detected Case of Atypical Bronchial Carcinoid on Stress Myocardial Perfusion SPECT/CT.

Myocardial perfusion imaging is primarily done to look for stress-induced perfusion defects in patients suspected of having coronary artery disease. However, the rotating raw images can provide significant information on the surrounding structures. The lungs lie near the heart, and any abnormality showing increased uptake can be seen on myocardial perfusion imaging.

Malignant gastrointestinal neuroectodermal tumor: A case-based review of literature.

Malignant gastrointestinal (GI) neuroectodermal tumor is an extremely rare entity that was first described by Zambrano et al. in 2003 as "clear cell sarcoma (CCS)-like tumor of the GI tract." It shares some of the histopathological features of CCS but lacks the immunohistochemical (IHC) reactivity for melanocytic markers.

Second Primary Spindle Cell Carcinoma of the Tongue: A Rare Histology.

Spindle cell carcinoma (SpCC) is a rare variant of poorly differentiated squamous cell carcinoma (SCC), characterised by the presence of both squamous (carcinomatous) and spindle cell (sarcomatous) elements. Early detection and improvement in treatment for oral SCC lead to prolonged survival, thereby increasing the frequency of second primary tumours (SPTs) in the oral cavity. In this paper, we report a case of SpCC of the tongue in a 62-year-old male with a history of SCC; the right lateral border of his tongue status post-treatment completion four years ago, now presented with a polypoidal growth over the tip of his tongue for four months.

Signet ring cell lymphoma of follicular type with BCL2 gene rearrangement: A rare case with a short review of literature.

A case of signet ring cell lymphoma of presacral lymph node is reported. The patient was diagnosed as follicular lymphoma on the basis of clinical and laboratory features, including immunohistochemistry (IHC) and gene rearrangement studies. Light microscopy examination showed neoplastic atypical cells with signet ring cell morphology in core biopsy of lymph node that stained for B-cell markers by IHC.

Metastatic primary gastric melanoma: a rare clinical presentation and a review of literature.

Primary gastric melanoma is a rare clinical finding. It presents with upper gastrointestinal symptoms like abdominal pain, weight loss and melaena. It is often difficult to differentiate a primary gastric melanoma from primary cutaneous melanoma with gastric metastasis.

Application of the Indian Academy of Cytologists Recommendations for Reporting Serous Fluid Cytopathology in Routine Reporting of Ascitic Fluid Specimen and Assessment of the Risk of Malignancy.

Background: A five-tiered reporting system for effusion fluid cytology has been published by the Indian Academy of Cytologists (IAC). Only a single study has evaluated the applicability of this system in routine reporting.

Aims: We intend to evaluate the practical utility of this system in routine reporting of ascitic fluid cytology.

Inguinal lymph node metastasis in treated breast cancer: an extremely rare presentation and review of literature.

Metastasis to inguinal lymph nodes from breast cancer is extremely rare and only a handful of cases have been reported in the literature to date. We report a case of a postmenopausal female patient who was a treated case of right breast cancer and developed inguinal metastases after 9 months. An excisional biopsy of the lesion confirmed the diagnosis.