Adolescent obesity and insulin resistance: The role of anthropometric indicators in metabolic health.

The present study investigates the relationship between obesity and metabolic, hormonal, and clinical indicators in adolescent girls. A total of 75 girls aged 15-19 years (mean age: 17.53 ± 1.

Hepatoprotective potential of Diospyros melanoxylon (Roxb.) leaf extract by inhibition of IL-6, COX-2, and 5-LOX expression in paracetamol intoxicated rats.

Ethnopharmacological Relevance: Diospyros melanoxylon, Roxb., (Ebenaceae), native to South and Southeast Asia, has been traditionally used to treat liver disorders, jaundice, tuberculosis, and chronic wounds and inflammatory conditions.

Aim Of The Study: To evaluate the hepatoprotective effect of D.

Genome-wide investigation of peptides containing tyrosine sulfation (PSY) gene family: identification, evolutionary and expression analysis in soybean (Glycine max L.).

Background: Soybean is a fundamental oilseed crop, recognized for its notable protein and oil levels. Tyrosine Sulfation (PSY) genes play an essential role in plant growth, development, and responses to stress. However, the precise functions and mechanisms regulated by PSY are still being explored.

Influence of Orange Oil on Skin Permeability, Dermatokinetics, and In Vivo Anti-inflammatory Properties of Lornoxicam-loaded Niosomal Gel.

Introduction: Lornoxicam is a non-steroidal anti-inflammatory drug belonging to the oxicam class. This study aimed to develop a niosomal gel containing orange oil for improving the anti-inflam-matory effect of lornoxicam.

Methods: Lornoxicam-loaded niosomes (LOR-OR-NIO) were prepared using film hydration followed by the sonication method.

Bifidobacteria in antibiotic-associated dysbiosis: restoring balance in the gut microbiome.

Antibiotic-associated dysbiosis disrupts the gut's microbial balance, leading to reduced diversity, overgrowth of antibiotic-resistant strains, and compromised gut homeostasis. This can result in inflammation, increased intestinal permeability, impaired immunity, and heightened susceptibility to infections. In this context, probiotics have been highlighted as a promising remedy in alleviating this antibiotic-induced gut microbiome aberrations with subsequent decrease of the detrimental effects.

Personalized precision: Revolutionizing cancer treatment with mRNA-based vaccines in melanoma therapy.

Biological and societal issues are involved when we refer to a condition as cancer, which connotes loss, complexity, and uncertainty. In recent decades, the number of melanomas has climbed. Cancer treatment vaccines have induced immune responses against tumor-associated but not tumor-specific antigens.

A perspective on the synthetic methodologies and biological attributes of thiazole-hydrazone compounds: a medicinal chemistry-based investigation.

Thiazole-hydrazone compounds serve as an essential bis-heterocyclic scaffold in drug discovery, combining the features of a thiazole ring and a hydrazone linkage. This combination offers enhanced biological activity and versatility due to the distinct characteristics of each component. The thiazole ring provides electron density through its sulfur and nitrogen atoms, contributing to lipophilicity and improved membrane permeability, which enhances the drug's ability to reach intracellular targets.

Advancements in lung cancer: molecular insights, innovative therapies, and future prospects.

Still among the most common and deadly cancers worldwide, lung cancer causes major morbidity and death. Thanks to late-stage diagnosis, tumor heterogeneity, and resistance to traditional treatments, the prognosis for lung cancer patients is still poor even with developments in medical research. The disease is driven by a sophisticated interaction of environmental elements, genetic alterations, and lifestyle choices like smoking, air pollution, and occupational toxins.

Advances in nanotechnology for colorectal cancer: a smart targeting and theranostics approach.

Colorectal cancer remains one of the most common and deadly malignancies globally, with high mortality rates, particularly in advanced stages. Conventional therapies such as surgery, chemotherapy, and radiotherapy, though beneficial, often suffer from drawbacks including systemic toxicity, multidrug resistance, and poor tumor selectivity. Recent progress in nanotechnology has introduced innovative theranostic strategies that integrate diagnosis and treatment using nanoparticle-based platforms.

A hybrid variational mode decomposition framework for enhanced cardiac output estimation using impedance cardiography.

Accurate cardiac output (CO) estimation from impedance cardiography (ICG) signals is vital for non-invasive monitoring of cardiovascular disorders, including heart failure, arrhythmias, and hemodynamic instability. However, the reliability of ICG-based assessment is often limited by noise artifacts that obscure clinically relevant features. This study introduces a novel three-stage denoising framework integrating Variational Mode Decomposition (VMD), Non-Local Means (NLM), and Discrete Wavelet Transform (DWT) to enhance ICG signal quality for robust CO estimation.

Advancing breast cancer research: a comprehensive review of in vitro and in vivo experimental models.

Breast cancer continues to be the leading cause of cancer-related fatalities and illnesses all over the world; thus, understanding its complex biology and developing improved treatment strategies requires a great deal of investigation. Examining tumor growth, drug response, and treatment effectiveness involves using experimental models. The in vitro and in vivo models employed in breast cancer research are extensively reviewed in terms of their applications, advantages, and disadvantages in this paper.

Integrated Approach towards Potential Therapeutic Agent for Inflammation-Mediated CVD Utilizing Computational and Experimental Studies.

Chronic inflammation plays a pivotal role in the development and progression of cardiovascular diseases (CVDs), posing a significant threat to global health. This study presents the synthesis and comprehensive characterization of N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-6-nitrobenzo[d][1,3]dioxole-5-carboxamide (EMC), a promising therapeutic candidate for inflammation-related CVD treatment. Insights into EMC's physicochemical properties were gained through density functional theory (DFT) studies, revealing an energy gap, ΔE (E-E) = 2.

Repurposing sulfonamide-scaffolds for enhanced and sustainable malaria therapy.

Malaria continues to pose a significant global health burden, with an estimated 263 million cases and 597,000 deaths reported in 2023, disproportionately affecting the WHO African Region. The emergence of drug-resistant strains has necessitated the search for novel therapeutic strategies. Sulfonamides, originally introduced as antibacterial agents, have been repurposed as promising antimalarial compounds due to their unique mechanism of action.

Design, synthesis and computational approach of vanillyl-imidazolidinyl-sulfamethoxazole derivatives as potent antimicrobial candidates tackling microbial resistance.

Superbugs are dominating the world due to the misuse and overuse of antibiotics. This study designed and synthesised two sets of compounds, oxazolones (3a-3j) and their respective imidazolones (4a-4j) bearing a sulfonamide functional group, with increased efficacy and capability to tackle microbial resistance. The structural conformation of compounds was determined using different techniques, including H/C NMR, FT-IR, HRMS and elemental analysis.

Optimizing wound healing: insights from phytochemicals and advanced therapies.

Wound healing is a complex process with various dimensions, often presenting as a growing concern that prompts the quest for advancements. This review emphasizes the therapeutic potential of medicinal plants rich in flavonoids, terpenoids, polyphenols, alkaloids, and steroids and discusses their valuable antibacterial, antioxidant, and anti-inflammatory properties in wound management. Cross talk of the phytochemicals with the intricate phases of wound healing, encompassing hemostasis, inflammation, proliferation, and remodeling is detailed, highlighting essential cellular and molecular mechanisms crucial for effective tissue repair.

Amlodipine protects the retinal ganglionic cell damage maintaining intra ocular pressure by regulating the biological activities of carrageenan like red algae: an in vivo and in-silico study.

Unlabelled: Carrageenan (Carr), a natural polysaccharide derived from edible red algae, was used for the green biosynthesis and also recognized as toxic compound causing oxidative stress. The objective was to know the insight mechanism of Carr-induced retino ganglionic cell (RGCs) damage and its connection with brain having two model systems, mammalian (rabbit), lower vertebrates (zebrafish). The present study investigated the modulatory effect of amlodipine (AML), a dihydropyridine calcium channel antagonist, against Carr-induced RGCs loss.

Pumpkin Seeds as a Natural Remedy for Anemia: Nutritional Insights and Therapeutic Potential.

Anemia is a widespread global health concern characterized by reduced hemoglobin levels and diminished oxygen-carrying capacity of the blood. According to the World Health Organization, anemia affects 40% of children aged 6 to 59 months, 37% of pregnant women, and 30% of women aged 15 to 49 years globally. The condition is primarily linked to iron deficiency, particularly in low- and middle-income countries, although other factors such as vitamin B12 insufficiency, parasitic infections, chronic diseases, and genetic disorders also contribute.

Putrescine mitigates NaCl-induced stress by modulating gene expression, antioxidants, and ethylene level in tomato.

Plant development and productivity are significantly hindered by salt stress, leading to substantial financial losses in the agriculture sector. Salinity stress negatively impacts the overall growth, physiology, and metabolism of plants. Specifically, NaCl stress is particularly harmful to tomato plants, causing suppression of seedling growth, accumulation of sodium (Na) and chloride (Cl) ions, disrupted ion homeostasis, reduced proline and chlorophyll content, and impairment of antioxidant enzyme systems.

Decoding soil health: essential indicators and management impacts.

Health of soil has a vital role in sustainable agriculture to ensure food security and preserve the environment. Global food demand is rising day by day, and crop plants fall in front of many challenges due to degeneration of soil as a result of non-judicious application of chemicals as well as water and air pollution. Collaborative efforts by farmers, policymakers, and researchers to promote sustainable practices are today's need.

Early detection of human Mpox: A comparative study by using machine learning and deep learning models with ensemble approach.

Objective: This study aims to enhance the early diagnosis of Mpox through machine learning (ML) and deep learning (DL) models, integrating an ensemble approach to improve classification accuracy.

Methods: We used the Mpox Skin Lesion Dataset v2.0, comprising six skin lesion categories, including chickenpox, cowpox, Mpox, measles, hand-foot-mouth disease, and healthy skin.

Metabolic and endocrine dysfunctions in traumatic brain injury: Implications for cognitive recovery and therapeutic strategies.

Traumatic brain injury (TBI) triggers a chain reaction of intricate metabolic abnormalities, sometimes leading to ongoing cognitive deficits. These abnormalities comprise dysregulation in trace element homeostasis, disrupted neurotransmitter modulation, increased lipid peroxidation, compromised glucose metabolism, and organ-specific metabolic changes. Most recent studies suggest that metabolic abnormalities are the root cause of cognitive decline in post-traumatic stress disorder.

Discovery of novel 1,3,4-oxadiazole derivatives as anticancer agents targeting thymidine phosphorylase: pharmacophore modelling, virtual screening, molecular docking, ADMET and DFT analysis.

Thymidine phosphorylase (TP) is a key enzyme involved in angiogenesis, tumour growth and closely linked to cancer progression and metastasis. This study represents the first comprehensive 3D-QSAR pharmacophore-based approach to identifying potential 1,3,4-oxadiazole derivatives as targeted TPIs for anticancer therapy. A dataset of 76 analogues with an experimental IC values was used to develop pharmacophore models.

Multifactorial analysis of dry eye syndrome: insights from Schirmer's test, VDT exposure, and tear film stability.

Objective: The current investigation represents to examine the numerous variables that influence tear film interactions alongside the seriousness regarding dry eye through adolescents and young adults, concentrating particularly regarding the implications of broadened Visual Display Terminal (VDT) usage, sleep deprivation, and the surrounding atmosphere. The inspection encompasses essential variables which include Schirmer's Test 1 (ST1), Tear Film Breakup Time (TBUT), ocular surface staining (OSS), tear osmolarity, blink rate, alongside symptom severity measured by the Ocular Surface Disease Index (OSDI).

Methods: Fifty participants (100 eyes; 33 males, 17 females), aged 18-25 years, were evaluated during morning and nocturnal phases following 5 h of VDT exposure.

Edible mushrooms as meat analogues: A comprehensive review of nutritional, therapeutic, and market potential.

Meat products are popular for their high protein content and sensory attributes, but their production poses health, environmental (human causes greenhouse gas emissions up to 14.5 %), and ethical challenges, prompting a search for sustainable meat alternatives. Additionally, consuming red meat can lead to health-related issues.