Pacing to pink noise enhances gait recovery from a mechanical perturbation.

Effective locomotion requires physiological systems to adapt to instabilities. While gait perturbation recovery often appears rapid, it is possible that longer-lasting effects may be present. Therefore, this study explored recovery trends of gait dynamics following an experimenter-induced perturbation.

Lobectomy or total thyroidectomy in pediatric differentiated thyroid cancer? A systematic review and meta-analysis.

Background: Thyroid cancer in pediatric patients is distinct from adult-onset thyroid cancer due to differences in disease presentation, management and outcomes. This meta-analysis delves into contemporary data on managing pediatric differentiated thyroid cancer (DTC), assessing outcomes, such as recurrence and mortality, in children with radical total thyroidectomy versus the more conservative lobectomy approach.

Methods: MEDLINE (via PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), trial registry websites (ClinicalTrials.

Hydrostatic pressure response of α-keratin investigated with Raman spectroscopy.

Keratins represent an important class of sulfur-rich structural proteins. In this study, the pressure response of α-keratin, extracted from sheep wool, was investigated using Raman spectroscopy up to 4 GPa. A non-polar liquid (a Fluorinert™ FC70/77 mixture) served as the Pressure Transmitting Medium (PTM) in a Diamond Anvil Cell (DAC).

The B cell dilemma: Diversity or fidelity?

The ability of B lymphocytes to diversify immunoglobulin (Ig) genes is central to the generation of high-affinity, class-switched antibodies and the establishment of effective humoral immunity. This diversification is achieved through three DNA remodeling processes that occur at defined stages of B cell development and maturation: V(D)J recombination, somatic hypermutation (SHM), and class switch recombination (CSR). These reactions all rely on the induction of programmed DNA lesions at Ig genes and their productive resolution by ubiquitous DNA repair pathways.

trials in ocular drug development: a new frontier in ophthalmology.

Introduction: In silico trials represent an unprecedented opportunity for ocular drug development. These trials not only promise significant reductions in costs and development timelines but also meaningful improvements in both patient safety and compliance.

Areas Covered: This critical perspective gives discussion to the value of in silico trials for novel ocular drug discovery and development.

Knowledge and attitudes of post-graduate dental students in Greece towards sleep disorders: A questionnaire-based study.

Aim: To assess sleep medicine and obstructive sleep apnea knowledge and management confidence among Greek dentists.

Methods: Postgraduate dental students at the Aristotle University of Thessaloniki completed the Assessment of Sleep Knowledge in Medical Education (ASKME) and the knowledge and attitudes towards obstructive sleep apnea (OSA) questionnaires (OSAKA) via an online survey from May to December 2022.

Results: The response rate was 77.

Assessing the impact of TET2 and TET3 deletion in TCRalpha and TCRbeta repertoire in murine CD4 T cells in physiological and pathophysiological conditions.

Ten Eleven Translocation (TET) proteins can oxidize 5-methylcytosine to generate in sequential steps oxidized forms of cytosine: 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine. Through their catalytic activity TET proteins promote active DNA demethylation. There are three TET proteins: TET1, TET2 and TET3.

Thoracoacromial Pedicle-Supercharged Conjoined Flap With Cutaneous Advancement Flap and Pectoralis Major Integration for Chest Wall Reconstruction Following Multiple Recurrent Dermatofibrosarcoma Protuberans: A Case Report.

Recurrent dermatofibrosarcoma protuberans (DFSP) of the anterior chest wall in elderly patients presents a complex reconstructive challenge, necessitating approaches that balance oncological radicality with minimized morbidity and optimal tissue quality for potential adjuvant radiotherapy. We report the case of an 84-year-old woman with an eighth recurrence of chest wall DFSP. Following wide local excision with clear margins, a significant soft tissue defect remained.

Reduction in Dressing Change Burden in Patients With Epidermolysis Bullosa-Impact of Oleogel-S10.

Epidermolysis bullosa (EB) is a severe genetic disorder marked by skin fragility and blistering from minimal trauma. Management relies on frequent and painful dressing changes. The EASE study (NCT03068780), the largest to date in EB, previously demonstrated accelerated wound healing and reduced wound burden for Oleogel-S10 (birch triterpenes) versus control gel.

Endometriosis and menopausal health: An EMAS clinical guide.

Introduction: Endometriosis is a common gynecological condition, and problems may persist or develop after the menopause. Endometriosis or its treatment in premenopausal women may lead to premature or early menopause. Thus, it is imperative that healthcare providers are appropriately trained in management of endometriosis at the menopause and beyond.

VaccineDesigner: A Web-Based Tool for Streamlined Multi-Epitope Vaccine Design.

Background: Multi-epitope vaccines have become the preferred strategy for protection against infectious diseases by integrating multiple MHC-restricted T-cell and B-cell epitopes that elicit both humoral and cellular immune responses against pathogens. Computational methods address various aspects independently, yet their orchestration is technically challenging, as most bioinformatics tools are accessible through heterogeneous interfaces and lack interoperability features. The present work proposes a novel framework for rationalized multi-epitope vaccine design that streamlines end-to-end analyses through an integrated web-based environment.

Independent neural drives and distinct motor unit discharge characteristics in hamstring muscles during isometric knee flexion.

Purpose: Our study investigated the discharge characteristics of motor units (MUs) in the semitendinosus (ST) and biceps femoris (BF) at three knee-joint angles that varied muscle length.

Methods: Fifteen males (21.1 ± 2.

Assistive technology for higher education students with disabilities: Knowledge and skills of teaching staff.

The use of assistive technology in education has been shown to enhance academic performance, increase educational engagement, and improve both academic self-efficacy and the social and psychological well-being of students with disabilities. Despite these proven benefits, assistive technology is not always utilized systematically or effectively. Many educators report feeling insufficiently competent in using assistive technology in the classroom, with their knowledge often being limited.

Uncovering the role of genetic polymorphisms in cervical insufficiency.

Cervical insufficiency (CI) is characterized by spontaneous dilation of the cervix in the absence of painful uterine contractions in the mid-trimester, leading to premature delivery. It is responsible for up to 20% of second trimester pregnancy losses, mostly <24 weeks. This life-threatening condition for the growing fetus faced during pregnancy is of complex etiology.

Evaluation of vitamin D status, vitamin D receptor expression, and innate immune mediators in COVID-19.

Background And Objectives: The Coronavirus disease 2019 (COVID-19) pandemic underscored the importance of identifying host factors that influence susceptibility to infection. Vitamin D signaling, mediated via its receptor (), along with innate immune mediators such as antimicrobial peptides (e.g.

Vegetarian diets for longevity: friend or foe?

Vegetarianism is a healthy dietary pattern that is postulated to increase longevity. Vegetarianism is adopted for animal ethics, environmental reasons, or religious beliefs. Vegetarian diets are believed to improve the gut microbiome, body weight, cardiovascular health and inflammation; however, a synthesis of the up-to-date evidence does not seem to support these effects.

Continuous Glucose Monitoring During Recreational Diving in Type 1 Diabetes: Navigating Clinical and Technical Uncertainties.

Recreational diving with self-contained underwater breathing devices is gaining popularity worldwide as a sport and leisure activity. People living with type 1 diabetes mellitus (PLT1D) are no exception, although historically diabetes mellitus, especially insulin-treated, has been described as an absolute contra-indication for diving. However, based on observational data collected by the Divers Alert Network, the presence of background diabetes mellitus became only a relative contraindication for those without significant co-morbidities or long-term complications.

Effect of alpha-tocopherol and OTR-4131 on muscle degeneration after rotator cuff tear in rats: An experimental protocol.

Background: Massive rotator cuff tears (RCTs) result in impaired shoulder function and quality of life. These tears lead to structural changes in the rotator cuff muscles, which compromise recovery after repair and increase re-tear rates.

Aim: To investigate the potential inhibitory effects of alpha-tocopherol (vitamin E) and OTR-4131 on muscle atrophy, fatty infiltration, and fibrosis in rotator cuff muscles following a massive RCT using a Wistar rat model, and establish a standardized methodology for evaluating potential therapeutic agents.

Need for combined therapy for a rare case of autoimmune autonomic ganglionopathy: A case report.

Background: Autoimmune autonomic ganglionopathy (AAG), formerly known as acute pandysautonomia, is a rare, acquired, antibody-mediated, potentially curable autonomic disorder that presents with diffuse autonomic failure. High levels of anti-ganglionic nicotinic acetylcholine receptor (gAChR) serum antibodies are detected in approximately 50% of AAG cases, confirming the diagnosis.

Case Summary: We present the case of a 68-year-old man who developed autonomic failure gradually over a 2-year period.

Cytoprotective effect of prostacyclin on hepatic ischemia-reperfusion injury.

Hepatic ischemia-reperfusion injury is an important mechanism of liver failure that occurs in many clinical conditions, including massive hemorrhage, major hepatectomy and liver transplantation, and leads to poor outcomes. The underlying cellular and molecular reactions are extremely complex and not completely understood. Anaerobic metabolism, ATP depletion, intracellular acidosis, calcium overload, mitochondrial dysfunction, oxidative stress, activation of Kupffer cells and neutrophils, platelet aggregation, nitric oxide production, activation of the complement system and overexpression of cytokines and chemokines constitute the main pathophysiological actions and pathways for possible therapeutic strategies.

Gonadotrophin dose in expected low responders undergoing ovarian stimulation for in-vitro fertilization/intracytoplasmic sperm injection: a systematic review and meta-analysis.

Introduction: Considering the prevalence and the importance of low ovarian response, it is important to update the evidence base on whether using higher compared to lower starting doses of gonadotrophins during ovarian stimulation of patients expected to exhibit low ovarian response is beneficial.

Evidence Acquisition: A systematic review and meta-analysis of randomized controlled trials (RCTs) was performed by performing literature search until December 2024 in MEDLINE, Embase, Cochrane CENTRAL, Scopus, Web of Science and Clinicaltrials.gov.

The Indo-European Cognate Relationships dataset.

The Indo-European Cognate Relationships (IE-CoR) dataset is an open-access relational dataset showing how related, inherited words ('cognates') pattern across 160 languages of the Indo-European family. IE-CoR is intended as a benchmark dataset for computational research into the evolution of the Indo-European languages. It is structured around 170 reference meanings in core lexicon, and contains 25731 lexeme entries, analysed into 4981 cognate sets.