Coenzyme Q10 may protect ovarian tissue against by the nearly century-old drug methotrexate caused gonadotoxicity: a biochemical, flow cytometric, and histopathological study.

Methotrexate (MTX) is still a broad-spectrum drug that has been used for almost a century for leukemia, rheumatoid arthritis, ectopic pregnancy. This study investigates the protective effects of coenzyme Q10 (CoQ10) on MTX induced gonadotoxicity. Twenty-four female wistar albino rats were divided into four groups.

Self-weighing and disordered eating among women: Exploring the moderating role of psychological resilience and self-compassion.

Self-weighing is a common practice among women, often associated with both adaptive and maladaptive eating behaviours, yet its psychological implications remain unclear. This study aims to examine the potential moderating roles of psychological resilience and self-compassion in the relationship between self-weighing frequency and disordered eating behaviours among women. The study sample consisted of 372 women with a mean age of 29.

Skin in the game: a review of computational models of the skin.

With the vast advances in computing technology, computational (or in silico) modelling has emerged as a transformative tool in dermatology. These findings can provide novel insights into complex biological processes and aid in the development of innovative therapeutic and regenerative strategies for the skin. Modelling combines experimental data and knowledge across multiple disciplines, serving as a common framework to elucidate the workings of the skin.

A New Approach for Respiratory Droplet Trajectory: Implications for Viral and Bacterial Disease Transmission in Emergency Departments.

Background: The objective of this study is to devise a simplified approach for estimating respiratory particle trajectory to avoid infection in gathering places of emergency departments.

Methods: To the authors' knowledge, no sufficient/obvious data exist on lateral routes of disease transmission through respiratory droplets along the -axis. The present study establishes a preliminary baseline approach based on the upper pharynx-mouth geometry for lateral social distancing to protect susceptible persons from the droplets of an infected person.

Lignocellulosic biomass based catalysis for hydrogen generation effect of pistachio shells and Raney nickel in NaBH hydrolysis.

Pistachio shell, which has a layered, porous structure, is a natural polymer composed of lignin, hemicellulose and cellulose. This study investigates the catalytic performance of a composite catalyst made from pistachio shell (PS) and Raney Ni (Ra-Ni) in sodium borohydride (NaBH) hydrolysis for hydrogen production. Characterization techniques, ATR-FTIR, XRD, TGA, and FESEM-EDX, were utilized to analyze the morphology and structure of the catalyst.

Nanoencapsulation of hydroxytyrosol extract of fermented olive leaf brine using proniosomes.

Background: Olive leaves are rich in bioactive compounds with potential health benefits; however, their limited bioavailability and stability hinder their effective utilization. Emerging technologies, nanocarrier-based delivery systems, have shown promise in enhancing these properties.

Results: The optimal conditions for proniosome formulation were 50 rpm rotational speed and 35 °C, achieving 81.

Morphometric effectiveness of calcium hydroxylapatite application in zygomatic and malar area on correction of nasolabial folds.

This study aims to investigate the indirect effects of calcium hydroxylapatite (CaHA) injections in the zygomatic and malar regions on the healing of nasolabial folds (NLFs). Given the anatomical complexity and proximity of the nasolabial area, selecting appropriate techniques for CaHA applications is crucial to prevent potential complications. The study is designed to contribute insights into the safety and efficacy of injections, aiming to enhance patient outcomes and minimize risks in aesthetic applications.

A comparative study of machine learning models for predicting neoadjuvant chemoradiotheraphy response in rectal cancer patients using radiomics and clinical features.

Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision is the standard treatment for locally advanced rectal cancer. However, the response to nCRT varies significantly among patients, making it crucial to identify those unlikely to benefit to avoid unnecessary toxicities. Radiomics, a technique for extracting quantitative features from medical images like computed tomography (CT), offers a promising noninvasive approach to analyze disease characteristics and potentially improve treatment decision-making.

Prevalence of Successful Aging among Turkish Adults, with Particular Focus on Age Groups and Living Space.

The older adult population in Türkiye is increasing, paralleling global trends; however, there is a lack of information regarding the prevalence of successful aging in the Turkish context. This study aims to fill this data gap by assessing both the objective and subjective prevalence of successful aging in Turkish adults aged ≥ 50 years. The study included 478 older adults (M = 72.

Recombinant Expression of L-methioninase from Brevibacterium linens and Evaluation of its Anticarcinogenic Properties against MiaPaCa-2 Cells.

Introduction: This study aimed to investigate the anti-carcinogenic effects of recombinant L- methioninase (rBlmet) on the pancreatic cancer cell line MiaPaCa-2.

Methods: In this study, rBlmet was initially cloned, expressed, and purified. To increase enzyme activity, the His-tags on the enzyme were removed using thrombin.

Chemical composition, characterization, and antimicrobial properties of essential oil-based nanoemulsions and its application on curd cheese.

Background And Aims: L. has been widely recognized as a food additive due to its therapeutic benefits and low toxicity risk. This study focuses on the chemical constituents of essential oil, antimicrobial, and antioxidant properties of essential oil (EO)-based nanoemulsions (NEs) and for the first time their effect on the preservation of curd cheese.

Comparative phytochemical analysis and bioactive potential of white and black garlic.

The phenolic and organosulfur compound profiles of black garlic samples produced at different temperatures, humidity and durations were determined using liquid chromatography-electrospray tandem mass spectrometry (LC-ESI-MS/MS) and their bioactive properties were compared with those of the white garlic samples. The total concentrations of the phenolic compounds in the white (fresh) garlic samples were observed at 24.15 mg/kg and it was found that caffeic and ferulic acids, epicatechin, apigenin and p-hydroxybenzoic acid were dominant.

Investigation of the Effects of Silicon Dioxide Nanoparticles and Environmental Contaminants on Immunocytotoxic and Antioxidant Defense Systems in Model Organism Galleria mellonella L.

Silicon dioxide (SiO) nanoparticles are chemically stable, biocompatible, abundant, and inexpensive. Moreover, they are highly surface-reactive. While these properties make them suitable for environmental applications, they also raise questions about their reactivity with environmental contaminants.

Impregnation of Melaleuca Family Essential Oil Nanoemulsions into Pectin:Polyvinyl Alcohol Patches to Provide an Antibacterial Environment for Infected Wounds.

Essential oils have long been utilized in food, cosmetic, and medicinal applications. Recently, their biomedical use for wound healing, skin repair, and tissue regeneration has gained considerable attention. In this study, tea tree oil (TTO) and niaouli oil (NIO) were formulated into aqueous nanoemulsions (NEs) and incorporated into pectin/polyvinyl alcohol (PP) thin films to develop antibacterial wound dressing patches.

Assessment of Anticancer Effects of Aloe vera on 3D Liver Tumor Spheroids in a Microfluidic Platform.

The search for effective anticancer therapies has increasingly focused on natural compounds like Aloe vera, renowned for its therapeutic properties. This study investigates the anticancer properties of Aloe vera on 3D liver tumor spheroids via a PDMS-based microfluidic device, providing a more physiologically realistic model compared to traditional 2D cultures. HepG2 cells were cultivated to generate 3D spheroids on-chip, thereafter subjected to different concentrations of Aloe vera and the chemotherapeutic drug Doxorubicin to evaluate cytotoxic effects.

Polar microalgae-based nanoparticles: a next-generation strategy for cancer treatment.

Polar microalgae are one of the species that produce valuable bioactives and effective antioxidants as a metabolic adaptation mechanism to tolerate harsh conditions of polar regions. In this manner, evaluating bioactive compounds obtained from polar microalgae against cancer cells is expected to offer promising outcomes. Among these bioactive compounds, the flavonoids found in microalgae stand out with their anticancer activity.

Optimal Cut-Off Point for Self-Rated Successful Aging Based on the Rowe and Kahn's Model.

There is no consensus on the optimal self-rated successful aging (SRSA) cut-off point for determining whether aging is successful. The present study aims to address this gap by identifying reliable SRSA cut-off points through a comparison based on Rowe and Kahn's (1997) successful aging model. A sample of 478 older adult residents of municipal centers and nursing homes aged ≥50 years ( = 72.

The tangible impacts of air pollution on built heritage during COVID-19 period on the Historical Peninsula of Istanbul, Turkey.

The degree of corrosion of the built cultural heritage site is examined considering the changes in air pollution trends during the COVID-19 pandemic, with the Historical Peninsula of Istanbul as a case study area. Key findings indicate that restricted mobility during stringent lockdown measures contributed to a noticeable reduction in PM, SO, NO, and O. This causes a temporary decrease in the surface recession rates and corrosion depths of the materials.

Biochemical Effects of Dietary Piperazine on Galleria mellonella L. (Lepidoptera: Pyralidae) as a Model Organism.

Insecticides used to control pests are one of the most important causes of environmental pollution. Therefore, eco-friendly novel chemicals with low toxicity to mammals are investigated in pest management. In the present study, we investigated the effects of piperazine, a clinically important drug, on the model pest Galleria mellonella (Lepidoptera: Pyralidae).

Insight into the Photoluminescence of BaCd(BO): RE (RE = Dy, Tb) Phosphors.

Dy and Tb ions doped BaCd(BO) phosphors with varying concentrations (2, 3, 4, 5, 6 mol%) were produced via the solid-state synthesis method in air. The as-synthesized phosphors were characterized. The photoluminescence (PL) and photoluminescence excitation (PLE) spectra of BaCd(BO) phosphors doped with 2, 3, 4, 5, and 6 mol% Dy ions reveal four distinct emission bands in the blue, yellow, and red regions, with the 575 nm emission band (F → H, electric dipole transition) exhibiting a notably higher intensity than the 481 nm band (F → H, magnetic dipole transition).

Fusion-Brain-Net: A Novel Deep Fusion Model for Brain Tumor Classification.

Problem: Brain tumors are among the most prevalent and lethal diseases. Early diagnosis and precise treatment are crucial. However, the manual classification of brain tumors is a laborious and complex task.

Antimicrobial Activity of Eco-Friendly Fly-Ash-Based Geopolymer Mortar.

As cement production causes large amounts of CO emissions and is not sustainable, there is a growing worldwide interest in developing cleaner construction materials by reducing carbon emissions and reusing existing industrial waste. Also, antimicrobially active construction materials are gaining attention due to enhancing structural longevity. By preventing microbial growth, these materials help to improve indoor air quality and occupant health.

Multiomics Analysis and Machine Learning-based Identification of Molecular Signatures for Diagnostic Classification in Liver Disease Types Along the Microbiota-gut-liver Axis.

Background: Liver disease, responsible for around two million deaths annually, remains a pressing global health challenge. Microbial interactions within the microbiota-gut-liver axis play a substantial role in the pathogenesis of various liver conditions, including early chronic liver disease (eCLD), chronic liver disease (CLD), acute liver failure (ALF), acute-on-chronic liver failure (ACLF), non-alcoholic fatty liver disease (NAFLD), steatohepatitis, and cirrhosis. This study aimed to identify key molecular signatures involved in liver disease progression by analyzing transcriptomic and gut microbiome data, and to evaluate their diagnostic utility using machine learning models.

5-Repurposed Drug Candidates Identified in Motor Neurons and Muscle Tissues with Amyotrophic Lateral Sclerosis by Network Biology and Machine Learning Based on Gene Expression.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that leads to motor neuron degeneration, muscle weakness, and respiratory failure. Despite ongoing research, effective treatments for ALS are limited. This study aimed to apply network biology and machine learning (ML) techniques to identify novel repurposed drug candidates for ALS.

TurkSentGraphExp: an inherent graph aware explainability framework from pre-trained LLM for Turkish sentiment analysis.

Sentiment classification is a widely studied problem in natural language processing (NLP) that focuses on identifying the sentiment expressed in text and categorizing it into predefined classes, such as positive, negative, or neutral. As sentiment classification solutions are increasingly integrated into real-world applications, such as analyzing customer feedback in business reviews (., hotel reviews) or monitoring public sentiment on social media, the importance of both their accuracy and explainability has become widely acknowledged.