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Statement Of Problem: Despite advances in artificial intelligence (AI), the quality, reliability, and understandability of health-related information provided by chatbots is still a question mark. Furthermore, studies on maxillofacial prosthesis (MP) information from AI chatbots are lacking.
Purpose: The purpose of this study was to assess and compare the reliability, quality, readability, and similarity of responses to MP-related questions generated by 4 different chatbots.
Material And Methods: A total of 15 questions were provided by a maxillofacial prosthodontist and from 4 different chatbots (ChatGPT-3.5, Gemini 2.5 Flash, Copilot, and DeepSeek V3). The Reliability Scoring (adapted DISCERN), the Global Quality Scale (GQS), the Flesch Reading Ease Score (FRES), the Flesch-Kincaid Reading Grade Level (FKRGL), and the Similarity Index (iThenticate) were used to evaluate the performance of chatbots. Data were compared using the Kruskal-Wallis test, and the differences between chatbots were determined by the Conover multiple comparison test with Benjamini-Hochberg correction (α=.05).
Results: There were no significant differences between the chatbots' DISCERN scores, except for one question where ChatGPT showed significantly higher reliability than Gemini or Copilot (P=.03). There was no statistically significant difference among AI tools in terms of GQS values (P=.096), FRES values (P=.166), and FKRGL values (P=.247). The similarity rate of Gemini was statistically higher than other AI chatbots (P=.03).
Conclusions: ChatGPT-3.5, Gemini 2.5 Flash, Copilot, and DeepSeek V3 showed good quality responses. All chatbots' responses were difficult for non-professionals to read and understand. Low similarity rates were found for all chatbots except Gemini, indicating originality of their information.
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http://dx.doi.org/10.1016/j.prosdent.2025.08.028 | DOI Listing |
Alzheimers Dement
September 2025
Department of Neurology, Beijing TianTan Hospital, Capital Medical University, Beijing, China.
Cognitive impairment and dementia, including Alzheimer's disease (AD), pose a global health crisis, necessitating non-invasive biomarkers for early detection. This review highlights the retina, an accessible extension of the central nervous system (CNS), as a window to cerebral pathology through structural, functional, and molecular alterations. By synthesizing interdisciplinary evidence, we identify retinal biomarkers as promising tools for early diagnosis and risk stratification.
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August 2025
Department of Ophthalmology, Stanford University, Palo Alto, CA, United States.
Introduction: Vision language models (VLMs) combine image analysis capabilities with large language models (LLMs). Because of their multimodal capabilities, VLMs offer a clinical advantage over image classification models for the diagnosis of optic disc swelling by allowing a consideration of clinical context. In this study, we compare the performance of non-specialty-trained VLMs with different prompts in the classification of optic disc swelling on fundus photographs.
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August 2025
Dept of Histopathology, PGIMER, Chandigarh, 160012, India.
Artificial intelligence (AI) is a technique or tool to simulate or emulate human "intelligence." Precision medicine or precision histology refers to the subpopulation-tailored diagnosis, therapeutics, and management of diseases with its sociocultural, behavioral, genomic, transcriptomic, and pharmaco-omic implications. The modern decade experiences a quantum leap in AI-based models in various aspects of daily routines including practice of precision medicine and histology.
View Article and Find Full Text PDFResearch (Wash D C)
September 2025
NHC Key Laboratory of Tropical Disease Control, School of Life Sciences and Medical Technology, Hainan Medical University, Haikou, Hainan 571199, China.
Aging is characterized by a gradual decline in the functionality of all the organs and tissues, leading to various diseases. As the global population ages, the urgency to develop effective anti-aging strategies becomes increasingly critical due to the growing severity of associated health problems. Immunotherapy offers novel and promising approaches to combat aging by utilizing approaches including vaccines, antibodies, and cytokines to target specific aging-related molecules and pathways.
View Article and Find Full Text PDFiScience
September 2025
School of Biology and Biological Engineering, South China University of Technology, Guangzhou, Guangdong 510006, China.
Deep learning has rapidly emerged as a promising toolkit for protein optimization, yet its success remains limited, particularly in the realm of activity. Moreover, most algorithms lack rigorous iterative evaluation, a crucial aspect of protein engineering exemplified by classical directed evolution. This study introduces DeepDE, a robust iterative deep learning-guided algorithm leveraging triple mutants as building blocks and a compact library of ∼1,000 mutants for training.
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