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Objectives: Type 2 diabetes (T2D) is a growing public health burden with persistent racial and ethnic disparities. . This study assessed the completeness of social determinants of health (SdoH) data for patients with T2D in Epic Cosmos, a nationwide, cross-institutional electronic health recors (EHR) database.
Materials And Methods: The study included adults with T2D (ICD-10: E11.*) with encounters between 2022 and 2024. We analyzed 11 individual-level SDoH data elements across 5 domains-financial strain, food insecurity, housing instability, intimate partner violence, and transportation needs-and 4 components of the Social Vulnerability Index (SVI), representing neighborhood-level SDoH. Data completeness for each data element (ie, the proportion of individuals with non-missing values) was evaluated using generalized linear models, adjusting for source healthcare organization, sex, and age.
Results: Among 12 031 927 individuals with T2D, adjusted completeness for individual-level SDoH data elements ranged from 11.2% to 31.5%, varying by data element and racial/ethnic group. American Indian or Alaska Native, Asian, Hispanic, and Native Hawaiian or Other Pacific Islander individuals had lower completeness for all individual-level SDoH compared to White individuals. In contrast, SVI data elements were available for nearly all patients since they are derived from patient addresses routinely collected in EHRs.
Discussion: While SVI data elements were widely available, individual-level SDoH data elements had significant missingness, limiting their usability for secondary analyses. Racial/ethnic disparities in SDoH completeness further complicate their use.
Conclusion: Standardized, equitable SDoH collection is critical to close documentation gaps, reduce disparities, and enable accurate, bias-resistant analyses in T2D care.
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http://dx.doi.org/10.1093/jamiaopen/ooaf095 | DOI Listing |
Infect Dis Poverty
September 2025
Faculty of Medicine and Pharmaceutical Sciences, University of Douala, Douala, Cameroon.
Background: Little is documented on key community-based One Health (OH) approach implementation, pro-activeness and effectiveness of interactions and strategies against Mpox outbreak public health emergency in international concern (PHEIC) in various African countries in order to stamp out the persisting Mpox outbreak threat and burden. Prioritizing critical community-based interventions and lessons learned from previous COVID-19, Mpox, Ebola, COVID-19, Rift Valley Fever and Marburg virus outbreaks revealed critical shortcomings in funding, surveillance, and community engagement that plague public health initiatives across the continent. The article provides critical insights and benefits of community-based One Health approaches implementation against Mpox outbreak management in Africa.
View Article and Find Full Text PDFBundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz
September 2025
Abteilung für Epidemiologie und Gesundheitsmonitoring, Robert Koch-Institut, Nordufer 20, 13353, Berlin, Deutschland.
Background: The prevalence of mental disorders in Germany is associated with socioeconomic position. International studies further indicate area-level correlations linking higher levels of socioeconomic deprivation with increased mental health burdens. However, these area-level associations have not yet been systematically examined in Germany and it is unclear whether socioeconomic disparities in mental health outcomes are contingent upon area-level socioeconomic deprivation.
View Article and Find Full Text PDFEur J Clin Pharmacol
September 2025
Hospital Management Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran.
Introduction: Metastatic breast cancer (mBC) is a major global health challenge. Antibody-drug conjugates (ADCs), including trastuzumab emtansine (T-DM1), trastuzumab deruxtecan (T-DXd), and sacituzumab govitecan (SG), offer clinical benefits but are associated with high costs, making cost-effectiveness assessments essential for policy decisions.
Methods: This systematic review analyzed economic evaluations comparing T-DM1, T-DXd, and SG with conventional treatments in breast cancer.
J Med Internet Res
September 2025
Dementia Care and Research Center, Peking University Institute of Mental Health (Sixth Hospital), Beijing, China.
Background: Informal caregivers of home-dwelling people with dementia experience significant unmet needs. However, family physician teams as primary health care gatekeepers for aging populations in China remain an underused resource for structured caregiver support.
Objective: This hybrid effectiveness-implementation study aimed to evaluate a policy-aligned integration of the World Health Organization's iSupport web-based program with China's family physician contract services for informal dementia caregivers while systematically assessing implementation determinants using the Consolidated Framework for Implementation Research (CFIR).
Am J Prev Med
September 2025
Social Determinants of Obesity and Cardiovascular Risk Laboratory, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA; Intramural Research Program, National Institute on Minority Health Disparities, National Institutes of Health, Bethesda, Maryland, USA
Background: Epidemiologic studies have linked neighborhood socioeconomic conditions to health. However, few have examined neighborhood structural investment (NSI) influences on cardiometabolic risk markers across urban environments. This study investigated whether NSI varies by historic redlining, associations between NSI and the prevalence of obesity, diabetes, and coronary heart disease (CHD) and whether redlining's effect on obesity, diabetes, and CHD prevalence are mediated by neighborhood structural investment.
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