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Epithelioid hemangioendothelioma (EHE) is an exceptionally rare vascular tumor with an incidence of <1/million people/year. This case report describes a patient who initially presented with progressive left-sided neck swelling and dysphagia and was found to have EHE at the confluence of the left subclavian and internal jugular veins. Diagnosis was confirmed with a core needle biopsy after an initial inconclusive fine-needle aspiration. Surgical management included direct laryngoscopy, left selective neck dissection (levels 2-4), left internal jugular vein sacrifice, and vascular reconstruction with a saphenous vein graft, followed by adjuvant radiation therapy due to positive margins. Early recognition of EHE in complex anatomical locations is essential and requires a multidisciplinary approach for optimal diagnosis and treatment.
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http://dx.doi.org/10.1177/01455613251374490 | DOI Listing |
Ear Nose Throat J
September 2025
Department of Otolaryngology-Head and Neck Surgery, OU Health, University of Oklahoma Health Sciences Center, OK, USA.
Epithelioid hemangioendothelioma (EHE) is an exceptionally rare vascular tumor with an incidence of <1/million people/year. This case report describes a patient who initially presented with progressive left-sided neck swelling and dysphagia and was found to have EHE at the confluence of the left subclavian and internal jugular veins. Diagnosis was confirmed with a core needle biopsy after an initial inconclusive fine-needle aspiration.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of Plastic and Reconstructive Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, South Korea.
Rationale: Epithelioid hemangioendothelioma (EHE) is a rare vascular malignancy which poses significant diagnostic and therapeutic challenges due to its variable course and lack of standardized treatment protocols. In this case, the lesion's benign appearance and ambiguous histology delayed definitive diagnosis.
Patient Concerns: A 46-year-old woman presented with a recurrent soft tissue mass in the left buttock.
Front Surg
August 2025
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Epithelioid hemangioendothelioma (EHE) is a rare and locally aggressive tumour of vascular endothelial origin, with an estimated prevalence of less than 1 in a million. EHE can arise in any part of the body, most commonly in the liver, lungs, and skeleton, while occurrence in the blood vessels of the extremities is rare. This article reports a rare case of primary epithelioid hemangioendothelioma (EHE) of the right femoral artery.
View Article and Find Full Text PDFCureus
July 2025
Gastroenterology and Hepatology, John H. Stroger, Jr. Hospital of Cook County, Chicago, USA.
Epithelioid hemangioendothelioma (EHE) is a rare vascular neoplasm that can involve multiple organs. Most cases are asymptomatic and detected incidentally, but the clinical course can vary significantly. A 40-year-old man presented with abdominal and chest pain; imaging revealed large hepatic masses along with pulmonary nodules.
View Article and Find Full Text PDFRespir Med Case Rep
August 2025
Department of Respiratory Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.
Epithelioid hemangioendothelioma (EHE) with pleural involvement presents significant diagnostic challenges, particularly in terms of differentiating it from malignant pleural effusion caused by other types of cancer, such as lung carcinoma. While most cases of EHE follow an indolent course, some can deteriorate rapidly, particularly those with serosal involvement such as pleural metastasis. In this report, we describe a case in which semi-rigid thoracoscopic cryobiopsy under local anesthesia yielded adequate specimens safely for diagnosis of pleural dissemination of EHE.
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