Pleural dissemination of epithelioid hemangioendothelioma diagnosed using semi-rigid thoracoscopic pleural cryobiopsy.

Epithelioid hemangioendothelioma (EHE) with pleural involvement presents significant diagnostic challenges, particularly in terms of differentiating it from malignant pleural effusion caused by other types of cancer, such as lung carcinoma. While most cases of EHE follow an indolent course, some can deteriorate rapidly, particularly those with serosal involvement such as pleural metastasis. In this report, we describe a case in which semi-rigid thoracoscopic cryobiopsy under local anesthesia yielded adequate specimens safely for diagnosis of pleural dissemination of EHE.

Rapidly progressive obstructive bioprosthetic valve thrombosis after surgical aortic valve replacement: a case report.

Background: Bioprosthetic valve thrombosis (BPVT) is an uncommon but potentially life-threatening complication following aortic valve replacement. The optimal management approach, whether surgical intervention or thrombolytic therapy, is controversial.

Case Summary: A 65-year-old male presented with exertional dyspnoea, and echocardiography confirmed severe aortic valve stenosis.

Entrectinib-Induced Brugada Syndrome Leading to Ventricular Tachycardia in A Patient with ROS1 Fusion-Positive Lung Adenocarcinoma.

Unlabelled: A 65-year-old male presented to the emergency room after experiencing syncope while driving, causing a self-inflicted accident. He had previously been diagnosed with stage IV A (cTXN2M1a) lung adenocarcinoma with C-ROS oncogene 1 (ROS1) fusion gene, wherein entrectinib (a multikinase inhibitor of ROS1, 600 mg orally once daily) was initiated as the first-line chemotherapy 12 days prior. He presented with haemodynamically unstable conditions without fever (blood pressure 89/42 mmHg; heart rate, 180/min).

Virtual reality-based training for radiopharmaceutical administration: development and educational effectiveness.

In Japan, task shifting and sharing are promoted to reduce the workload of physicians. Radiological technologists have been assigned new responsibilities, such as securing venous access for radiopharmaceutical administration. This study aimed to develop a prototype Virtual Reality (VR) training system that allows safe and repeatable training for radiological technologists.

Safety and efficacy of transbronchial cryobiopsy for elderly lung cancer patients.

Background: The increasing prevalence of lung cancer in the elderly population necessitates a closer evaluation of diagnostic and therapeutic approaches. This study aimed to compare the safety and diagnostic efficacy of transbronchial lung cryobiopsy (TBLC) between patients ≥ 80 years and younger patients.

Methods: A retrospective review was conducted of 96 patients diagnosed with peripheral lung cancer who underwent TBLC between April 2021 and October 2023.

Successful chemical ablation for intraventricular septal ventricular tachycardia-An alternative approach to the septal branch.

Trans-coronary ethanol ablation for ventricular tachycardia originating from the ventricular septum is effective, but there are cases with no septal perforator from left anterior descending artery. CT and angiography can reveal the optimal vessel.

Development of a dose estimation system for external exposure assessment at the late phase for individuals living in areas affected by the Fukushima nuclear accident.

Although the elevated ambient dose equivalent (ADE) rates in areas radiologically affected by the 2011 Fukushima nuclear plant accident decreased as time passed, the assessment of Fukushima residents' external dose is still important. A dose estimation system for external exposure assessment at the late phase for individuals living in Fukushima Prefecture was developed for this purpose. The developed system enables the estimations of external doses over the future based on an individual behavioral pattern and ADE-rate distributions from aerial monitoring data and its predicted ADE rate.

Impact of high frequency stimulation to confirm a complete box isolation in catheter ablation of non-paroxysmal atrial fibrillation.

Introduction: Pulmonary vein (PV) isolation (PVI) including the left atrial posterior wall (LAPW) (Box-PVI) is proposed as an additional strategy for non-paroxysmal atrial fibrillation (NPAF), however, the efficacy remains controversial. The more reliable and durable the Box-PVI we can create, the better the rhythm outcomes might be than with a conventional PVI alone. This study focused on the potential exit conduction of the box lesion and investigated whether the conventional Box-PVI would be sufficient.

Visual Field Test With Gaze Check Tasks: Application in a Homonymous Hemianopic Patient Unaware of the Visual Defects.

Gaze control is required for applying visual stimuli to a particular area of the visual field. We developed a visual field test with gaze check tasks to investigate hemianopia. In this test, participants must report the presence or absence of visual stimuli when a small object at the fixation point vibrates.

Changing Emotions About Fukushima Related to the Fukushima Nuclear Power Station Accident-How Rumors Determined People's Attitudes: Social Media Sentiment Analysis.

Background: Public interest in radiation rose after the Tokyo Electric Power Company (TEPCO) Fukushima Daiichi Nuclear Power Station accident was caused by an earthquake off the Pacific coast of Tohoku on March 11, 2011. Various reports on the accident and radiation were spread by the mass media, and people displayed their emotional reactions, which were thought to be related to information about the Fukushima accident, on Twitter, Facebook, and other social networking sites. Fears about radiation were spread as well, leading to harmful rumors about Fukushima and the refusal to test children for radiation.

Rapid Recovery From Cortical Blindness Caused by an Old Cerebral Infarction.

When the primary visual cortex (V1) is damaged, cortical blindness results. However, visual information obtained from the superior colliculus (SC) or direct thalamic afferents to higher visual cortices produces unconscious visual functions called blindsight. Alarming visual stimuli suggesting the approach of a predator are known to trigger escape behaviors via visual information mediated by the SC and amygdala in small animals, and salient and dynamic visual stimuli also produce some conscious visual experience even in patients with blindsight.

Potential complications in patients undergoing an ethanol injection into the vein of Marshall.

Background: Ethanol injections into the vein of Marshall (VOM) (EIM) are considered to be a good therapeutic option for atrial tachyarrhythmias, however, the safety remains to be determined. To elucidate what would affect the safety and potential complications of an EIM, we investigated the anatomical features of the VOM and patient background.

Methods: We performed the EIM before the conventional pulmonary vein isolation for drug-resistant atrial fibrillation in 88 patients and evaluated the anatomical features of the VOM and their background.

Investigation of multiple-dynein transport of melanosomes by non-invasive force measurement using fluctuation unit χ.

Pigment organelles known as melanosomes disperse or aggregate in a melanophore in response to hormones. These movements are mediated by the microtubule motors kinesin-2 and cytoplasmic dynein. However, the force generation mechanism of dynein, unlike that of kinesin, is not well understood.

Analysis of the Regionality of the Number of Tweets Related to the 2011 Fukushima Nuclear Power Station Disaster: Content Analysis.

Background: The Great East Japan Earthquake on March 11, 2011, triggered a huge tsunami, causing the Fukushima Daiichi nuclear disaster. Radioactive substances were carried in all directions, along with the risks of radioactive contamination. Mass media companies, such as television stations and news websites, extensively reported on radiological information related to the disaster.

Relationships Among Tweets Related to Radiation: Visualization Using Co-Occurring Networks.

Background: After the Fukushima Daiichi nuclear accident on March 11, 2011, interest in, and fear of, radiation increased among citizens. When such accidents occur, appropriate risk communication must provided by the government. It is therefore necessary to understand the fears of citizens in the days after such accidents.

Detection of Minimal Bone Marrow involvement of Blastic Plasmacytoid Dendritic Cell Neoplastic Cells - CD303 immunostaining as a diagnostic tool.

Blastic plasmacytoid dendritic cell (pDC) neoplasm (BPDCN) is a relatively rare hematological malignancy with significantly complex clinicopathological features that are still unclear. This study aimed to analyze the clinicopathological data of BPDCN and evaluate immunohistochemical detection of minimal bone marrow (BM) involvement. In this study, we examined skin and BM lesions from 6 patients with BPDCN.

Non-invasive force measurement reveals the number of active kinesins on a synaptic vesicle precursor in axonal transport regulated by ARL-8.

Kinesin superfamily protein UNC-104, a member of the kinesin-3 family, transports synaptic vesicle precursors (SVPs). In this study, the number of active UNC-104 molecules hauling a single SVP in axons in the worm Caenorhabditis elegans was counted by applying a newly developed non-invasive force measurement technique. The distribution of the force acting on a SVP transported by UNC-104 was spread out over several clusters, implying the presence of several force-producing units (FPUs).

Imidazolium-based anion exchange membranes for alkaline anion fuel cells: (2) elucidation of the ionic structure and its impact on conducting properties.

In our previous study (Soft Matter, 2016, 12, 1567), the relationship between the morphology and properties of graft-type imidazolium-based anion exchange membranes (AEMs) was revealed, in that the semi-crystalline features of the polymer matrix maintain its mechanical properties and the formation of interconnected hydrophilic domains promotes the membrane conductivity. Here, we report a novel ionic structure of the same graft-type AEMs with different grafting degrees, analyzed using a small-angle X-ray scattering method under different relative humidity (RH) conditions. The characteristic "ionomer peak" with a corresponding correlation distance of approximately 1.

Effects of in vivo deletion of GATA2 in bone marrow stromal cells.

The bone marrow (BM) microenvironment comprises multiple stem cell niches derived from BM mesenchymal stem cells (MSCs). Previous in vitro analyses have suggested that transcription factor GATA2 plays an important role in adipocyte differentiation of BM-MSCs and in hematopoietic support, but the role of GATA2 in vivo remains unknown. We evaluated GATA2 effects in BM-MSCs in vivo.

Feasibility of intermittent back-filtrate infusion hemodiafiltration to reduce intradialytic hypotension in patients with cardiovascular instability: a pilot study.

Background: Intradialytic hypotension (IDH) is one of the major problems in performing safe hemodialysis (HD). As blood volume depletion by fluid removal is a major cause of hypotension, careful regulation of blood volume change is fundamental. This study examined the effect of intermittent back-filtrate infusion hemodiafiltration (I-HDF), which modifies infusion and ultrafiltration pattern.

Inhibition of human primary megakaryocyte differentiation by anagrelide: a gene expression profiling analysis.

Anagrelide is a treatment option for patients with essential thrombocythemia. Although the clinical efficacy of anagrelide has been established, there is limited knowledge of the molecular mechanism underlying its effect. Here, we evaluated the effect of anagrelide on primary megakaryocytic progenitors from cord blood-derived CD34-positive cells.

Fatal visceral varicella-zoster developing early after autologous hematopoietic stem cell transplantation for refractory diffuse large B-cell lymphoma.

A middle-aged woman who had undergone autologous hematopoietic stem cell transplantation (HSCT) 1 month previously suffered severe epigastralgia and relapse of lymphoma. The epigastralgia was not relieved by chemotherapy. Thereafter, her pancreatic and hepatic enzyme levels were markedly elevated and disseminated varicella emerged.

Effect of licorice flavonoid oil on cholesterol metabolism in high fat diet rats.

Dietary licorice fravonoid oil (LFO) significantly decreased hepatic cholesterol and plasma lipoprotein cholesterol levels in high-fat diet rats. It significantly suppressed hydroxymethylglutaryl-CoA synthase activity and increased cholesterol 7α-hydroxylase activity. The low density lipoprotein receptor mRNA level was significantly increased by LFO.