98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412237 | PMC |
http://dx.doi.org/10.1186/s12864-025-12004-y | DOI Listing |
NAR Genom Bioinform
September 2025
DNA Repair and Recombination Laboratory, St Vincent's Institute of Medical Research, Fitzroy VIC 3065, Australia.
Meiotic crossovers promote correct chromosome segregation and the shuffling of genetic diversity. However, the measurement of crossovers remains challenging, impeding our ability to decipher the molecular mechanisms that are necessary for their formation and regulation. Here we demonstrate a novel repurposing of the single-nucleus Assay for Transposase Accessible Chromatin with sequencing (snATAC-seq) as a simple and high-throughput method to identify and characterize meiotic crossovers from haploid testis nuclei.
View Article and Find Full Text PDFBMC Genomics
September 2025
Biodiversity and Crop Improvement Program, International Center for Agricultural Research in the Dry Areas, Rabat, 10100, Morocco.
J Physiol
September 2025
Department of Physiology, Anatomy & Genetics, University of Oxford and Daegu-Gyeongbuk Institute of Science and Technology, South Korea.
The cardiac pacemaker activity is formed from multiple interlocking physiological networks, any one of which can generate rhythm. The interlocking is reciprocal so that they automatically replace each other. In such interlocking control systems, the association scores for individual components are necessarily low, even though causation, measured by the electric current carried by the relevant ion channels, is large.
View Article and Find Full Text PDFZhonghua Nan Ke Xue
August 2025
Department of Urology, Northern Jiangsu People's Hospital Afflicted to Yangzhou University Yangzhou, Yangzhou, Jiangsu 225001, China.
Objective: To evaluate the association between erectile dysfunction (ED) and myocardial infarction (MI) using two sample Mendelian randomization.
Methods: A Mendelian randomization study was conducted using comprehensive data on ED and MI from extensive genome-wide association data. Using inverse variance weighted analysis for causal relationships, and correct for confounding factors using multivariate Mendelian randomization, the potential mediating effects were evaluated as well.
J Asthma
September 2025
Institute of Tropical Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Background: Pediatric asthma (PA) is the prevailing chronic respiratory ailment in childhood. A better understanding of plasma metabolites is the goal for elucidating the molecular pathological mechanisms of PA and investigating novel therapeutic approaches.
Methods: Data for PA from Genome-Wide Association Studies (GWAS) was derived from the IEU-OpenGWAS project, featuring a collection of 1400 plasma metabolites.