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Case Summary: We present a case of a 31-year-old man with a history of aortic valve endocarditis and surgical aortic intervention. Computed tomography revealed a complex serpiginous fistula with 2 openings between the left ventricular outflow tract and the left atrium. Using 3-dimensional printing simulation for device fit testing and planning, the "mother-in-daughter" system, multimodality guidance with computed tomography angiography C-arm prediction, and 3-dimensional transesophageal echocardiogram guidance successfully guided an 18-mm Cribriform Amplatzer device deployed via a retrograde approach.
Take-home Message: Three-dimensional printing simulation significantly enhances preprocedural planning and device selection for this complex fistula closure, facilitating successful percutaneous repairs in high-risk patients.
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http://dx.doi.org/10.1016/j.jaccas.2025.104889 | DOI Listing |
JACC Case Rep
September 2025
Center for Structural Heart Disease, Henry Ford Health System, Detroit, Michigan, USA. Electronic address:
Case Summary: We present a case of a 31-year-old man with a history of aortic valve endocarditis and surgical aortic intervention. Computed tomography revealed a complex serpiginous fistula with 2 openings between the left ventricular outflow tract and the left atrium. Using 3-dimensional printing simulation for device fit testing and planning, the "mother-in-daughter" system, multimodality guidance with computed tomography angiography C-arm prediction, and 3-dimensional transesophageal echocardiogram guidance successfully guided an 18-mm Cribriform Amplatzer device deployed via a retrograde approach.
View Article and Find Full Text PDFJ Orthop Translat
November 2025
Medical 3D Printing Center, Orthopedic Institute, Department of Orthopedic Surgery, The First Affiliated Hospital, School of Basic Medical Sciences, Interdisciplinary Innovation Center for Nanomedicine, MOE Key Laboratory of Geriatric Diseases and Immunology, Suzhou Medical College, Soochow Universi
Background: Intervertebral disc (IVD) herniation is a major cause of low back pain and disability, with microdiscectomy being the standard surgical treatment. However, microdiscectomy fails to address annulus fibrosus (AF) defects, increasing the risk of recurrent herniation. Current therapeutic strategies for this condition remain limited in efficacy.
View Article and Find Full Text PDFInt J Pharm
September 2025
Programa de Pós-Graduação em Ciências Farmacêuticas, Faculdade de Farmácia Universidade Federal do Rio Grande do Sul, Avenida Ipiranga, 2752, Porto Alegre, Rio Grande do Sul 90610-000, Brazil; Laboratório de Nanocarreadores e Impressão 3D em Tecnologia Farmacêutica (Nano3D), Faculdade de Fa
The implementation of 3D printing technologies in clinical settings depends on formulations that are not only printable and compliant with quality standards but also physicochemical stable and reliable under real-use conditions. This study evaluated the in-use and long-term physicochemical and rheological stability of two hydrogel inks developed for semisolid extrusion (SSE) 3D printing: one containing pimobendan (PBD) and the other a placebo. PBD is a poorly water-soluble drug used to treat canine heart failure, whose formulation challenges highlight the potential of personalised drug delivery.
View Article and Find Full Text PDFBiomed Phys Eng Express
September 2025
Institute of Electrical Engineering Chinese Academy of Sciences, No.6, Zhongguancun Road, Haidian District, Beijing , China, Beijing, Beijing, 100190, CHINA.
Objective: Transcranial magnetic stimulation (TMS) is a promising neuromodulation therapy for treating diseases such as depression and Alzheimer's disease. However, its efficacy depends on precise magnetic field targeting. Current measurement methods face a trade-off between accuracy and complexity.
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Aim: This study investigates the application of three-dimensional (3D) printing in cancer research and treatment, highlighting the current advancements, key areas of interest, and emerging trends in the field.
Methods: Literature records and cited references were retrieved from the Web of Science Core Collection (WOSCC) database and analyzed using Excel 2019, Bibliometrix, VOSviewer, and CiteSpace. Based on the scientometric results, a stratified and focused thematic analysis was performed by cancer type to enhance clinical relevance and investigate tumor-specific applications.