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Mucormycosis is predominantly caused by members of the genera Lichtheima, Mucor, and Rhizopus. Here, we report the genome assemblies and comparative analyses of the clinically relevant species Mucor ardhlaengiktus (CBS 210.80), Mucor circinelloides (CBS 195.68) Mucor janssenii (CBS 205.68), and Mucor griseocyanus (CBS 116.08), to enable molecular analyses.
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http://dx.doi.org/10.1093/mmy/myaf081 | DOI Listing |
Biotechnol Lett
September 2025
Shandong Provincial Engineering Research Center for Precision Nutrition and Healthy Elderly Care, Qilu Medical University, 1678 Renmin West Road, Zibo, 255300, People's Republic of China.
Fatty acid synthase (FAS) is one of the most important enzymes in lipid biosynthesis, which can catalyze the reaction of acetyl-CoA and malonyl-CoA to produce fatty acids. However, the structure, function, and molecular mechanism of FAS regulating lipid synthesis in the fungus Mucor circinelloides are unclear. In the present study, two encoding fas genes in the high lipid-producing strain WJ11 and low lipid-producing strain CBS277.
View Article and Find Full Text PDFFungal Biol
October 2025
Colin Ratledge Center for Microbial Lipids, School of Agricultural Engineering and Food Science, Shandong University of Technology, Zibo, 255000, Shandong, China; School of Basic Medicine, Qilu Medical University, Zibo, 255300, Shandong, China. Electronic address:
Oleaginous filamentous fungus Mucor circinelloides harbors a GATA transcription activator AreA, which regulates nitrogen metabolism. In our previous study, deletion of AreA resulted in increased lipid production, while its overexpression reduced lipid synthesis. Although it is not a direct lipogenesis regulator, AreA influences metabolic flux by modulating nitrogen utilization pathways, which in turn affects carbon distribution.
View Article and Find Full Text PDFG3 (Bethesda)
September 2025
Norwegian University of Life Sciences, 1433 Ås, Norway.
Fungi are pivotal in transitioning to a bio-based, circular economy due to their ability to transform organic material into valuable products such as organic acids, enzymes, and drugs. Mucor circinelloides is a model organism for studying lipogenesis and is particularly promising for its metabolic capabilities in producing oils like TAGs and carotenoids, influenced by environmental factors such as nutrient availability. Notably, strains VI04473 and FRR5020 have been identified for their potential in producing single-cell oils and carotenoids, respectively.
View Article and Find Full Text PDFMed Mycol
September 2025
Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands.
Mucormycosis is predominantly caused by members of the genera Lichtheima, Mucor, and Rhizopus. Here, we report the genome assemblies and comparative analyses of the clinically relevant species Mucor ardhlaengiktus (CBS 210.80), Mucor circinelloides (CBS 195.
View Article and Find Full Text PDFCardiol Rev
September 2025
Division of Infectious Diseases, Department of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY.
Mucorales endocarditis is an extremely rare and devastating disease, with few cases reported in the literature. The infection is predominantly found in immunocompromised patients, although a few cases involving immunocompetent individuals have been reported. We reviewed all cases of mucor endocarditis reported to date with a focus on demographics, clinical presentations, and the range of predisposing conditions, including immunosuppressive states, recent surgery, and cardiac device implantation.
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