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Objectives: Major advancements have been made in applying artificial intelligence and computer vision to analyze videolaryngoscopy data. These models are limited to post hoc analysis and are aimed at research settings. In this work, we assess the feasibility of a real-time solution for automated vocal fold tracking during in-office laryngoscopy.
Methods: We trained a keypoint detection model that tracks 39 individual keypoints of the larynx, optimized for real-time deployment, on 1254 frames extracted from 57 laryngoscopy videos. Images were annotated with keypoints along the true and false vocal folds, and supraglottic structures. After training, the model was evaluated on a validation dataset of 140 test images, and second independent test dataset of 50 images. Performance was assessed by comparing manual keypoint annotations to predicted annotations and computing mean keypoint accuracy ( ), and by calculating temporal consistency ( ) from a calibration video clip. The live feed of a flexible laryngoscope, mounted to an endoscopic tower, was passed via a video capture card into a laptop running the motion tracking model in real-time.
Results: The model demonstrated robust detection accuracy with an of 85% and 75% with validation and test datasets, and promising temporal consistence of 5.85 average pixel movement. During testing, the model ran at 30 frames per second, with minimal appreciable latency while processing the laryngoscope's live feed, ensuring the laryngologist's work was not affected.
Conclusion: The model accurately tracks laryngeal structures with strong detection, localization, and consistency, is compatible with affordable hardware, and enables real-time metric development.
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http://dx.doi.org/10.1002/lary.70104 | DOI Listing |
J Robot Surg
September 2025
Orlando Health Advanced Robotic Surgery Center, Orlando, FL, USA.
Teleproctoring offers a remote alternative to traditional surgical mentoring, addressing logistical barriers in robotic surgery education. We conducted a prospective trial to assess the feasibility and trainee perception of teleproctoring using the Proximie platform. Eighteen surgeons with limited robotic experience performed a standardized enterotomy closure on synthetic bowel models using the da Vinci Si system, while receiving real-time remote guidance from an expert located 2570 km away.
View Article and Find Full Text PDFFood Chem
September 2025
School of Food Science and Engineering, Wuhan Polytechnic University, Wuhan 430028, China.
A versatile fluorescent molecularly imprinted nanosensor (MIPs@O-CDs) for profiling ciprofloxacin (CIP) was innovatively developed using a controllable post-imprinting modification strategy. High-affinity molecularly imprinted polymers (MIPs) as recognition elements granted nanosensor favorable anti-interference. Bright orange-emission carbon dots (O-CDs) as signal transducers demonstrated prominent reverse fluorescence response to CIP due to inner filter effect, ameliorating detection sensitivity and accuracy.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
School of Graduate Study, University of Chinese Academy of Sciences, Beijing, 100049, China.
Brain-computer interfaces (BCIs) enable communication between individuals and computers or other assistive devices by decoding brain activity, thereby reconstructing speech and motor functions for patients with neurological disorders. This study presents a high-resolution micro-electrocorticography (µECoG) BCI based on a flexible, high-density µECoG electrode array, capable of chronically stable and real-time motor decoding. Leveraging micro-nano manufacturing technology, the µECoG BCI achieves a 64-fold increase in electrode density compared to conventional clinical electrode arrays, enhancing spatial resolution while featuring scalability.
View Article and Find Full Text PDFSmall Methods
September 2025
Department of Pathology, College of Medicine, Hanyang University, Seoul, Republic of Korea.
While human epidermal growth factor receptor (HER2) has emerged as a tumor-agnostic biomarker, standard HER2 testing for anti-HER2 therapies using immunohistochemistry (IHC) and in situ hybridization (ISH) assays remains subjective, time-consuming, and often inaccurate. To address these limitations, an ultrafast and precise HER2 testing method is developed using Lab-On-An-Array (LOAA) digital real-time PCR (drPCR), a fully automated digital PCR enabling real-time absolute quantification. A multicenter study involving four independent breast cancer cohorts cross-validates the high diagnostic accuracy of drPCR-based HER2 assessment.
View Article and Find Full Text PDFTransplant Cell Ther
September 2025
The Dartmouth Institute for Health Policy & Clinical Practice; Geisel School of Medicine at Dartmouth, Level 5, Williamson Building, One Medical Center Drive, Lebanon, NH, 03756.
Background: The use of patient-reported outcome measures (PROMs) can improve a patient's clinical course by decreasing the incidence and severity of both physical and emotional treatment-related toxicities, uncover unmet patient needs and assist in patients' shared decision-making.
Objectives: The objective of this study was to examine the feasibility and utility of using electronically captured "real time" agenda-setting questions and PROMs at the time of the patient's clinic visit.
Study Design: We designed a prospective observational study that employed a pre-visit questionnaire (PVQ) that included agenda-setting questions and the PROMIS-29 survey, with results incorporated into a clinical decision support dashboard embedded within the patients' electronic medical record (EMR).