The Clinical Utility of Real-Time Patient Reported Outcomes in Cell Therapy Recipients.

Background: The use of patient-reported outcome measures (PROMs) can improve a patient's clinical course by decreasing the incidence and severity of both physical and emotional treatment-related toxicities, uncover unmet patient needs and assist in patients' shared decision-making.

Objectives: The objective of this study was to examine the feasibility and utility of using electronically captured "real time" agenda-setting questions and PROMs at the time of the patient's clinic visit.

Study Design: We designed a prospective observational study that employed a pre-visit questionnaire (PVQ) that included agenda-setting questions and the PROMIS-29 survey, with results incorporated into a clinical decision support dashboard embedded within the patients' electronic medical record (EMR).

Potential of MRNA vaccines for mpox prevention: current evidence and future directions.

In 2022, the presumption of monkeypox (mpox) to be of limited epidemiology shifted when a global outbreak was announced. Being a member of the Orthopoxvirus genus in the Poxviridae family, it'd been reported in over 82 countries with over 17 000 confirmed cases by July 2022, thus showing its capability for spreading rapidly. As the smallpox vaccine offers 85% cross-immunity against mpox, the outbreak highlighted the attenuation of global immunity against orthopoxviruses after the cessation of vaccination campaigns against smallpox.

Antioxidant Performance in UHMWPE Knee Bearings: A Mid-Term Retrieval Report.

Joint arthroplasty bearing materials must maintain a balance between wear resistance, toughness, and oxidation resistance. Antioxidant-doped polyethylene has been introduced to stabilize free radicals resulting from the cross-linking process while avoiding mechanical property losses associated with previous generations of highly cross-linked polyethylene. Furthermore, the antioxidant should prevent or greatly reduce oxidation occurring in vivo.

Red light photodynamic therapy with 10% aminolevulinic acid gel showed efficacy for treatment of superficial basal cell carcinoma in a randomized, vehicle controlled, double-blind, multicenter phase III study.

Background: Surgical procedures remain the gold standard for treating basal cell carcinoma (BCC), although commonly associated with cosmetic defects. The demand for non-invasive alternatives remains high.

Objective: To determine efficacy and safety of red light photodynamic therapy (PDT) with 10% 5-aminolevulinic acid (ALA) gel vs.

Clinical and Administrative Perspectives on Prior Authorization for Residential Substance Use Disorder Treatment: A Qualitative Analysis.

The objective of this study was to describe the clinical experiences associated with billing for short-term residential care for substance use disorder (SUD) under a Medicaid managed care organization (MCO) payment structure requiring prior authorization. The authors conducted a qualitative analysis of focus group data collected from residential adult services (RAS) facilities staff in West Virginia between 2020 and 2022. These primary data were derived from 17 semi-structured focus groups across 11 distinct RAS facilities, which included 28 administrators, 23 clinicians, and 10 peer recovery support specialists, and were recorded and transcribed before being coded.

Hydroxychloroquine reduces metastatic tumor burden in pancreatic adenocarcinoma through myeloperoxidase inhibition.

Background: Metastatic pancreatic adenocarcinoma has a 5-year survival of only 3%. Neutrophil extracellular traps are formed when neutrophils expel their intracellular contents and have been intricately linked to metastases. Hydroxychloroquine is an FDA-approved anti-malarial drug and neutrophil extracellular trap inhibitor with high potential for clinical translation.

Unmet Mentorship Needs in Academic Internal Medicine: A Survey of Faculty Affiliated with a U.S. Medical School.

Background: Mentorship is an important resource for professional development and success.

Objective: Evaluate differences in mentorship with respect to personal, professional, and academic characteristics.

Design: Mixed-methods study using semi-structured interviews and a survey.

Major publications in the critical care pharmacotherapy literature: 2024.

Objectives: To summarize, analyze, and provide clinical insights on the most impactful publications related to critical care pharmacotherapy in 2024.

Methods: A systematic search of PubMed/Medical Literature Analysis and Retrieval System Online (MEDLINE) was conducted between January 1, 2024, and December 31, 2024. Randomized controlled trials, prospective study designs, or retrospective study designs with high-quality methodology of adult critically ill patients assessing a pharmacotherapeutic intervention and reporting clinical endpoints were considered for inclusion.

Intraoperative Tracheostomy Complications.

Tracheostomy is a routinely performed procedure, especially for patients who need long-term intubation, frequent pulmonary suctioning, or airway protection due to neurologic conditions. Despite being commonly performed, tracheostomy can lead to distinct complications that require careful surgical technique and an understanding of individual patient factors. In this review, we focus on the intraoperative complications that have been reported in the literature.

Utility of advance care planning billing codes: a cross-sectional analysis of U.S. hospitalists' documentation.

Objective: To establish the validity of Advance Care Planning (ACP) billing codes 99497 and 99498 to measure ACP occurrence in the hospital.

Results: As part of a clinical trial testing the effect of a physician-directed intervention on ACP for hospitalized older adults, we conducted a retrospective chart review of physician notes to assess validity of ACP billing codes on Medicare claims. Among 434 inpatient stays managed by 39 hospitalists at 35 hospitals, 85 (19.

Methodological recommendations for assessing the impact of adaptations on outcomes in implementation research.

Background: A major gap in implementation research is guidance for designing studies to assess the impact of adaptations to interventions and implementation strategies. Many researchers regard experimental designs as the gold standard. However, the possible study designs for assessing the impact of adaptation on implementation, service and person-level outcomes is broad in scope, including descriptive and correlational research and variations of randomized controlled trials.

"What Program Directors Think" VI: Results of the 2024 Survey of the APDR Part 2.

Rationale And Objectives: The Association of Program Directors in Radiology (APDR) surveys its members for data gathering on impediments to resident education, variations in resource allocation and recent changes to the American Board of Radiology (ABR) certifying examination.

Materials And Methods: This was an observational, cross-sectional study using a Web-based survey. Members of the 2022-2023 Annual Survey Committee developed survey questions resulting in 40 items, including demographic data.

Feasibility and Usability of a Web-Based Peer Support Network for Care Partners of People With Serious Illness (ConnectShareCare): Observational Study.

Background: While it can be rewarding to provide care for a person with serious illness, care partners are often unprepared to manage and cope with the physical and emotional stresses that arise with disease progression and bereavement.

Objective: We aimed to evaluate membership enrollment, engagement, and experiences within a web-based peer support network for active and bereaved care partners of people with serious illness.

Methods: We conducted a formative evaluation of the ConnectShareCare peer-to-peer web-based support network, which targeted care partners of people with serious illness residing in the northeastern United States.

Approaching an Undiagnosed Pleural Effusion.

Pleural effusions are commonly encountered in the practice of pulmonary medicine, and their clinical evaluation is usually straightforward. However, up to 20% of pleural effusions are not diagnosed despite clinical evaluation and pleural fluid analysis. Further investigation of the undiagnosed pleural effusion requires a systematic evaluation using clues from a patient's history, physical examination, imaging, and pleural fluid analysis help narrow down the differential diagnosis.

Beyond Hybrid Morphology: A Large Series of Fusion-Driven Benign Peripheral Nerve Sheath Tumors Including 5 Tumors With Novel Fusions.

Benign peripheral nerve sheath tumors (PNSTs) represent a heterogeneous group of neoplasms with varying histologic and molecular characteristics. Although traditional classifications categorize these tumors based on predominant cell types, recent advances in molecular pathology have revealed the presence of hybrid tumors featuring elements from at least 2 nerve sheath tumors (hybrid peripheral nerve sheath tumor [hPNST]). We herein studied 20 cases of hPNST involving 15 female and 5 male patients (median age, 29.

Open Questions in Surgery for Hepatoblastoma: A Joined SIOPEL-IPSO Survey.

Introduction: Surgery is pivotal in the management of hepatoblastoma (HB) although approaches and techniques may vary. The Liver Group of the International Society of Pediatric Oncology (SIOPEL) and the International Pediatric Surgical Oncology (IPSO) group collaborated to develop an online survey to investigate specific technical aspects and challenging indications for HB surgery, with the goal of establishing shared guidelines.

Methods: An electronic survey with 50 items was developed to address preoperative assessment and specific surgical issues.

Characterizing Interpretive and Diagnostic Competency Development in Pathology Training.

Accurate disease diagnosis is the cornerstone of patient care, directly impacting the quality of health care delivery and patient outcomes. Developing diagnostic competence is a critical goal of pathology residency training. This study uses longitudinal data from trainees during pathology residency to examine the association between years of training and performance in 4 key interpretive phases: detecting critical regions, recognizing their relevance, describing histopathological features, and rendering an accurate diagnosis.

Management of SGLT2i-associated perioperative ketoacidosis (SAPKA) / Euglycemic Diabetic Ketoacidosis (EDKA).

This infographic reviews the risk of perioperative euglycemic diabetic ketoacidosis (EKDA) associated with sodium-glucose co-transporter 2 inhibitor (SGLT2i), which is more specifically called SGLT2i-associated perioperative ketoacidosis (SAPKA). The incidence of SAPKA/perioperative EDKA is estimated to be 0.17 % for nonemergent procedures and 1.

Physical well-being and burden of care in adults on modulator therapy: A mixed methods study of patient-reported experiences from the Well-ME survey.

Background: Despite widespread availability of modulator therapies and improved lung function in many people with cystic fibrosis (CF), physical symptoms may remain burdensome for some people with CF (PwCF). This study identifies the impact of ivacaftor (IVA) and elexacaftor/tezacaftor/ivacaftor (ETI) on self-reported physical well-being and burden of care among adults with CF.

Methods: We conducted a secondary analysis of data from the Well-ME Survey.

Crystal structures of the putative endoribonuclease L-PSP from Entamoeba histolytica.

Entamoeba histolytica causes amebiasis, a neglected disease that kills ∼100 000 people globally each year. Due to emerging drug resistance, E. histolytica is one of the target organisms for structure-based drug discovery by the Seattle Structural Genomics Center for Infectious Disease (SSGCID).

Failed Thumb Basal Joint Arthroplasty: An Analysis of Common Etiologies Leading to Reoperation.

Purpose: Hand osteoarthritis contributes considerably to functional disability, and the basal joint is the most common site treated surgically. Procedure choice is largely based on surgeon preference, and causes of primary basal joint arthroplasty failure and prevalence of revision are poorly defined. We seek to understand the etiologies of revision basal joint surgery.

The Challenges of Using ChatGPT for Clinical Decision Support in Orthopaedic Surgery: A Pilot Study.

Background: Artificial intelligence (AI) technologies have recently exploded in both accessibility and applicability, including in health care. Although studies have demonstrated its ability to adequately answer simple patient issues or multiple-choice questions, its capacity for deeper complex decision making within health care is relatively untested. In this study, we aimed to delve into AI's ability to integrate multiple clinical data sources and produce a reasonable assessment and plan, specifically in the setting of an orthopaedic surgery consultant.