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Background: Diagnostic errors are harmful and occur at unacceptably high rates. However, data regarding diagnostic errors in pediatric populations, particularly in acute outpatient care settings, remain insufficient. This study aimed to investigate the frequency of diagnostic errors, contributing factors, common symptoms, initial diagnoses, and final diagnoses in pediatric outpatient acute care in Japan and clarify the challenges that should be prioritized for preventing such errors.
Methods: A secondary analysis of the Nationwide Survey on Diagnostic Errors in Pediatric Outpatient Acute Care questionnaire data was performed.
Results: In total, 1511 responses were received from the members of the Japan Pediatric Society. Cognitive factors, particularly insufficient information gathering, were identified as the primary contributors to diagnostic errors. Situational factors such as high workload and limited time were prominent factors, particularly in clinics. Among the most memorable cases of diagnostic errors, the chief complaints at the initial visit were frequently fever, abdominal pain, and vomiting. The common initial diagnoses included gastroenteritis, upper respiratory infection, and lower respiratory infection, whereas the final diagnoses were appendicitis, encephalitis/encephalopathy, and intussusception. Diagnostic errors with poor outcomes frequently involved final diagnoses of encephalitis/encephalopathy, myocarditis, and testicular torsion.
Conclusions: Caution should be exercised to avoid diagnostic errors when addressing the chief complaints and initial diagnoses frequently identified in this study. Diseases listed as final diagnoses should be prioritized in the differential diagnoses. Addressing the factors contributing to diagnostic errors, along with increased awareness and targeted strategies for differential diagnosis, may reduce diagnostic errors and improve healthcare quality.
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http://dx.doi.org/10.1111/ped.70183 | DOI Listing |
Zhong Nan Da Xue Xue Bao Yi Xue Ban
May 2025
Department of Geriatric Pulmonary and Critical Care Medicine, Xiangya Hospital, Central South University; National Clinical Research Center for Geriatric Disorders (Xiangya Hospital), Changsha 410008.
Objectives: Non-small cell lung cancer (NSCLC) is associated with poor prognosis, with 30% of patients diagnosed at an advanced stage. Mutations in the and genes are important prognostic factors for NSCLC, and targeted therapies can significantly improve survival in these patients. Although tissue biopsy remains the gold standard for detecting gene mutations, it has limitations, including invasiveness, sampling errors due to tumor heterogeneity, and poor reproducibility.
View Article and Find Full Text PDFAnal Chim Acta
November 2025
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, China. Electronic address:
Background: The development of specific fluorescent probes for cancer cell discrimination holds significant promise for advancing cancer diagnostics. Conventionally, these probes operate by translating differences in biomarkers or microenvironmental factors into variations in whole-cell fluorescence intensity. However, this dominant, intensity-based strategy is highly susceptible to extraneous fluctuations arising from probe concentration, illumination instability and complex intracellular environment.
View Article and Find Full Text PDFAm J Med Sci
September 2025
The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, Israel; Department of Internal Medicine, Lady Davis Carmel Medical Center, Haifa, Israel.
Objective: Multifocal atrial tachycardia (MAT), characterized by an irregularly irregular rhythm, is often regarded as a clinical imitator of atrial fibrillation (AF). We aimed to evaluate the prevalence of MAT misclassification as AF in the emergency department (ED) setting.
Methods: A retrospective analysis of 1,828 ECGs from patients discharged with AF diagnoses over five years.
BMJ Open
September 2025
University of Birmingham, Birmingham, UK.
Objective: To explore experience and prevalence of vulval lichen sclerosus (VLS) diagnosis in general practice using an anonymous patient survey.
Design: Quantitative descriptive cross-sectional survey informed by previous qualitative interviews and developed with patient representatives, sent to people recorded in general practice as having a VLS diagnosis.
Setting: General practices (n=24) in the UK (West Midlands).
Introduction: Neurovascular compression (NVC) often drives trigeminal neuralgia (TGN) pathology. This study examines the incidence, diagnostic accuracy, and role of NVC.
Methods: We conducted a retrospective review of patients ≥18 years with medically refractory TGN who underwent MRI, plus a secondary cohort of medically responsive patients.