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http://dx.doi.org/10.3389/fcimb.2025.1667802 | DOI Listing |
Cell Mol Life Sci
September 2025
Department of Neurology, The Second Affiliated Hospital of Xinjiang Medical University, Ürümqi, 830054, Xinjiang, China.
Microglial activation-induced neuroinflammation and impaired neuronal mitophagy are recognized as pivotal pathogeneses in Parkinson's disease (PD). However, the role of microglial mitophagy in microglial activation during PD development remains unclear, and therapeutic interventions targeting this interaction are lacking. Rhapontigenin (Rhap), a stilbenoid enriched in Vitis vinifera, exhibits dual anti-neuroinflammatory and mitophagy-enhancing properties, but its therapeutic potential and mechanisms in PD are unexplored.
View Article and Find Full Text PDFDig Dis Sci
September 2025
Department of Gastroenterology & Hepatology, Singapore General Hospital, Singapore, Singapore.
Account Res
September 2025
Psychiatry Residency, Community Memorial Healthcare, Ventura, CA, USA.
Objective: To compare self-publication rates by editors-in-chief (EICs) of psychiatry vs. medicine journals before, during, and after their editorships.
Methods: Frequency of self-publication by 25 psychiatry EICs and 22 medicine EICs across seven journals in each specialty was determined for 5 years before, the years during, and 5 years after their tenures.
Environ Pollut
September 2025
National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650
Plastic pollution is ubiquitous in aquatic ecosystem, posing growing threats to ecosystem health. Maternal transfer of polystyrene nanoplastics (PS-NPs) is known to impair offspring development, yet the underlying molecular mechanisms driving these transgenerational effects remain poorly understood. This study aimed to elucidate the mechanisms by which maternal PS-NPs exposure disrupts embryonic development and locomotion in zebrafish offspring, with a specific focus on mitochondrial dysfunction.
View Article and Find Full Text PDFJ Nutr
September 2025
Health and Kinesiology, University of Illinois, Urbana-Champaign, Urbana, IL, USA; Department of Medicine, Division of Geriatrics and Gerontology, Emory University, Atlanta, GA, USA; Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, Urbana, IL; Personalized Nutrition Initia
Background: Arterial stiffness, assessed via carotid femoral pulse wave velocity (cfPWV), is a marker of vascular aging that may contribute to cognitive decline. Serum carotenoids, with antioxidant properties, may mitigate these effects, but their role in moderating neurovascular-cognitive relationships remains unclear.
Objective: This study examined: (1) associations between cfPWV and executive function, (2) the contribution of serum carotenoids in predicting cfPWV, and (3) whether carotenoids moderate the relationship between cfPWV and executive function.