Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Sleep disorders are closely linked to stroke, while the role of gut microbiota in human health and disease is increasingly recognized. However, the causal relationships between sleep disorders, gut microbiota, and stroke remain unclear.
Objective: This study aimed to investigate the causal relationships between sleep disorders, gut microbiota, and stroke (including its subtypes), as well as the potential mediating role of gut microbiota in the association between sleep disorders and stroke.
Methods: Using a two-sample Mendelian randomization approach, we analyzed causal relationships among various sleep disorders, gut microbiota, and stroke. The inverse variance weighted method served as the primary analysis, supplemented by multiple sensitivity analyses to ensure robustness. Mediation effects of gut microbiota in the sleep disorder-stroke relationship were assessed using the coefficient product method.
Results: Insomnia was causally associated with transient ischemic attacks (OR = 1.592, 95% CI: 1.116-2.270), excessive daytime sleepiness with ischemic stroke (IS) (OR = 1.887, 95% CI: 1.041-3.420), and sleep apnea with overall stroke risk (OR = 1.247, 95% CI: 1.015-1.532). Several gut microbiota taxa showed causal associations with stroke and its subtypes, with Ruminococcus E sp900314705 increasing the risk of overall stroke, IS, and transient ischemic attacks. Ezakiellaceae partially mediated the causal relationship between daytime sleepiness and IS, accounting for 15.9% of the effect.
Conclusion: The current study established and elucidated causal relationships between sleep disorders and stroke, identified specific gut microbiota associated with stroke risk, and highlighted the mediating role of Ezakiellaceae in the causal relationship between daytime sleepiness and IS. These findings underscore the potential importance of improving sleep quality and modulating gut microbiota for stroke prevention and management.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s42000-025-00711-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intestinal epithelial Dicer1 regulates gut microbiome and Alzheimer's pathology in App-knock-in mice.
Alzheimers Res Ther
September 2025
Department of Neurology, Saarland University, Kirrberger Straße, 66421, Homburg/Saar, Germany.
Background: Alzheimer's disease (AD) patients and animal models exhibit an altered gut microbiome that is associated with pathological changes in the brain. Intestinal miRNA enters bacteria and regulates bacterial metabolism and proliferation. This study aimed to investigate whether the manipulation of miRNA could alter the gut microbiome and AD pathologies.
View Article and Find Full Text PDFGut health and physiological aspects of broiler chicken fed zeolite as a dietary supplement: its effect on growth, cecal microbiota and digesta viscosity, digestive enzymes, carcass traits, blood constituents and antioxidant parameters.
BMC Vet Res
September 2025
Department of Poultry Production, Faculty of Agriculture, Fayoum University, Fayoum, 63514, Egypt.
This study investigated the impact of dietary zeolite supplementation on growth, cecal microbiota and digesta viscosity, digestive enzymes, carcass traits, blood constituents, and antioxidant parameters of broilers. A completely randomized design was used with 240 one-day-old broiler chicks randomly assigned to three dietary treatments (0%, 1.5%, and 3% zeolite as a feed additive) with four replicates of 20 chicks each.
View Article and Find Full Text PDFKetogenic Diet Mitigates Age-Related Cognitive Decline and Neuroinflammation in Rats, While Antibiotics Exacerbate Brain Health Risks.
J Mol Neurosci
September 2025
Department of Physiology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
The ketogenic diet (KD), a high-fat, low-carbohydrate regimen, has been shown to exert neuroprotective effects in various neurological models. This study explored how KD-alone or combined with antibiotic-induced gut microbiota depletion-affects cognition and neuroinflammation in aging. Thirty-two male rats (22 months old) were assigned to four groups (n = 8): control diet (CD), ketogenic diet (KD), antibiotics with control diet (AB), and antibiotics with KD (KDAB).
View Article and Find Full Text PDFcomprehensive review of ciprofloxacin pollution in water: sources, environmental impacts, remediation techniques, and research challenges.
Environ Monit Assess
September 2025
School of Chemical Engineering, Universiti Sains Malaysia, Engineering Campus, 14300, Nibong Tebal, Penang, Malaysia.
Ciprofloxacin (CIP), a widely used fluoroquinolone antibiotic, has become a significant contaminant in aquatic environments due to its extensive use and incomplete metabolism. This review comprehensively analyses CIP pollution, including its sources, environmental and health impacts, and removal strategies. Chemical methods such as advanced oxidation processes and physical techniques like adsorption are evaluated for their efficiency in CIP removal.
View Article and Find Full Text PDFThe multi-kingdom cancer microbiome.
Nat Microbiol
September 2025
Joan and Sanford I. Weill Department of Medicine, Gastroenterology and Hepatology Division, Weill Cornell Medicine, New York, NY, USA.
Microbial influence on cancer development and therapeutic response is a growing area of cancer research. Although it is known that microorganisms can colonize certain tissues and contribute to tumour initiation, the use of deep sequencing technologies and computational pipelines has led to reports of multi-kingdom microbial communities in a growing list of cancer types. This has prompted discussions on the role and scope of microbial presence in cancer, while raising the possibility of microbiome-based diagnostic, prognostic and therapeutic tools.
View Article and Find Full Text PDF