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Purpose: This study evaluates and compares surgical complications, functional outcomes, and quality of life between single-stage and staged posterior sagittal anorectoplasty (PSARP) procedures in female patients with Rectovestibular fistula (RVF) over a 25-year period.
Methods: A retrospective cohort study was conducted on 54 female patients with RVF treated between 1999 and 2024. Patients were categorized into Group 1 (n = 42, single-stage PSARP) and Group 2 (n = 12, staged PSARP). Demographics, associated anomalies, postoperative complications, Krickenbeck continence scores, and Pediatric Quality of Life Inventory (PedsQL) scores were analyzed and compared.
Results: Group 1 showed significantly higher rates of surgical site infection (22.2% vs. 8.3%, p = 0.01), wound dehiscence (17.8% vs. 8.3%, p = 0.03), and mucosal prolapse (13.3% vs. 0%, p = 0.001). Conversely, anal stenosis occurred only in Group 2 (16.7%, p = 0.001). Voluntary bowel movements (88% vs. 83%, p = 0.86) and reoperation rates (8.9% vs. 8.3%, p = 0.88) were similar across groups. Longitudinal analysis revealed progressive improvement in bowel control and quality of life with age, irrespective of surgical method. PedsQL scores increased from 73.4 in early childhood to 85.5 in adulthood.
Conclusion: Both single-stage and staged PSARP are effective in achieving long-term continence in RVF patients. While the single-stage approach carries higher early wound-related risks, it remains a viable option for well-selected, low-risk patients. Staged repair may be more appropriate for high-risk cases to reduce early complications. Individualized surgical planning and long-term follow-up are essential to optimize functional and psychosocial outcomes.
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http://dx.doi.org/10.1007/s00383-025-06177-6 | DOI Listing |
JAMA
September 2025
Department of Cardiology, Chengdu Integrated TCM & Western Medicine Hospital, Chengdu, China.
Clin Appl Thromb Hemost
September 2025
Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong, China.
Hemophilia, an X-linked monogenic disorder, arises from mutations in the or genes, which encode clotting factor VIII (FVIII) or clotting factor IX (FIX), respectively. As a prominent hereditary coagulation disorder, hemophilia is clinically manifested by spontaneous hemorrhagic episodes. Severe cases may progress to complications such as stroke and arthropathy, significantly compromising patients' quality of life.
View Article and Find Full Text PDFJAMA
September 2025
Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.
JAMA Surg
September 2025
Department of Surgery, Meander Medical Center, Amersfoort, the Netherlands.
Importance: Stoma reversal is associated with few complications. However, recent studies show that 1 in 3 patients develop an incisional hernia, for which half of the patients receive surgical correction.
Objective: To investigate whether prophylactic synthetic mesh placement in the retromuscular space during stoma reversal reduces the rate of stomal site incisional hernias.
JAMA Netw Open
September 2025
School of Nursing, Capital Medical University, Beijing, China.
Importance: The efficacy of home end-of-life care in enhancing the quality of life for terminally ill patients and families has been well documented. While previous studies have explored perspectives on quality home palliative care and end-of-life care in several countries, limited knowledge exists regarding its specific components in the Chinese context.
Objective: To explore the core elements that constitute quality home end-of-life care in China.