Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Hepatocellular carcinoma (HCC) ranks as the fifth most prevalent malignancy worldwide. Disruptions in copper homeostasis adversely affect liver function. Cuproptosis, a recently defined form of regulated cell death triggered by intracellular copper accumulation, disrupts the tricarboxylic acid cycle and mitochondrial respiration. However, the specific roles and mechanisms of cuproptosis-related genes (CRGs) in HCC pathogenesis remain incompletely understood.
Materials And Methods: We systematically evaluated the expression of 10 CRGs in HCC tissues versus adjacent normal tissues. Bioinformatics analyses included Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and Gene Set Enrichment Analysis (GSEA) were performed. Immune infiltration levels within the tumor microenvironment were assessed. The prognostic significance of CDKN2A was evaluated using Kaplan-Meier (KM) survival analysis and univariate/multivariate Cox proportional hazards regression. CDKN2A protein expression was validated using immunohistochemistry (IHC).
Results: CDKN2A was significantly overexpressed in HCC compared to normal tissues. Bioinformatics analyses implicated CDKN2A in DNA replication, organelle fission, and cell cycle checkpoint signaling. Immune-related analysis revealed that high CDKN2A expression correlated positively with dendritic cell (DC) and Th2 cell infiltration, but negatively with CD8 + T cell and natural killer (NK) cell infiltration. KM analysis demonstrated that high CDKN2A expression predicted significantly shorter overall survival in HCC patients. Univariate and multivariate Cox regression identified CDKN2A as an independent prognostic risk factor.
Conclusions: This study demonstrates that CDKN2A is significantly overexpressed in HCC and plays a role in immune microenvironment modulation. CDKN2A serves as a promising independent prognostic biomarker for HCC, associated with poorer patient survival.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398455 | PMC |
| http://dx.doi.org/10.1007/s12672-025-03496-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prognostic impact of gene alterations via homologous recombination DNA repair gene alteration status in pancreatic ductal adenocarcinoma.
Front Med (Lausanne)
August 2025
Department of Medical Oncology, Kindai University Faculty of Medicine, Osakasayama, Japan.
Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, with limited treatment options and poor prognosis. Recent advances in cancer genomic analysis enable the identification of actionable gene alterations, opening new opportunities for personalized therapy. Among these, homologous recombination DNA repair (HRR) gene alterations are associated with distinct biological behavior, favorable prognosis, and increased sensitivity to platinum-based chemotherapy.
View Article and Find Full Text PDFBackground: This study aims to gain further insights into the characteristics of the rare subtype of acute myeloid leukemia (AML) with BCR∷ABL by analyzing laboratory detection results of various gene mutations, such as NPM1.
Methods: Laboratory detection results of multiple gene missense mutations, including NPM1, were analyzed in a case of primary AML with BCR∷ABL.
Results: The patient exhibited morphological features of acute leukemia in the bone marrow.
KDM4A-induced tumor senescence enhances the efficacy of immunotherapy by inhibiting AGT-PHB1 axis-mediated mitophagy in colorectal cancer.
Autophagy
September 2025
Department of General Surgery (Colorectal Surgery), The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Immune checkpoint inhibitors (ICIs) can re-active the immune response and induce a complete response in mismatch repair-deficient and microsatellite instability-high (dMMR/MSI-H) colorectal cancer (CRC). However, most CRCs exhibit proficient mismatch repair and microsatellite stable (pMMR/MSS) phenotypes with limited immunotherapy response because of sparse intratumoral CD8 T-lymphocyte infiltration. Cellular senescence has been reported to involve immune cell infiltration through a senescence-associated secretory phenotype (SASP).
View Article and Find Full Text PDFNext-generation sequencing identifies potential mechanisms of primary resistance to trastuzumab-containing therapies in HER2-positive gastric cancer: Analysis based on real-world data and online databases.
Hum Vaccin Immunother
December 2025
Department of Oncology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Trastuzumab-containing therapy remains a treatment option for patients with HER2-positive gastric cancer (GC). However, primary resistance to trastuzumab is a challenge. Therefore, it is essential to identify biomarkers for predicting the efficacy of trastuzumab-based treatment.
View Article and Find Full Text PDF[Clinicopathological characteristics of well-differentiated papillary mesothelial tumor].
Zhonghua Bing Li Xue Za Zhi
September 2025
Department of Pathology, the Affiliated Hospital of Qingdao University, Qingdao 266000, China.
To investigate the clinicopathological characteristics of well-differentiated papillary mesothelial tumor (WDPMT). Sixteen cases of resected WDPMTs diagnosed at the Affiliated Hospital of Qingdao University, Qingdao, China from 2017 to 2024 were collected and the clinicopathological features were retrospectively analyzed. There were 7 males amd 9 females, with a mean age of 53.
View Article and Find Full Text PDF