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Article Abstract
Introduction: Positron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated the relationship between SV2A PET and CSF synaptic protein changes of AD patients.
Method: Twenty-one participants with early AD and seven cognitively normal (CN) individuals underwent [C]UCB-J PET. We used mass spectrometry to measure a panel of synaptic proteins in cerebrospinal fluid (CSF).
Results: In the AD group, higher levels of syntaxin-7 and PEBP-1 were associated with lower global synaptic density. In the total sample, lower global synaptic density was associated with higher levels of AP2B1, neurogranin, γ-synuclein, GDI-1, PEBP-1, syntaxin-1B, and syntaxin-7 but not with the levels of the neuronal pentraxins or 14-3-3 zeta/delta.
Conclusion: Reductions of synaptic density found in AD compared to CN participants using [C]UCB-J PET were observed to be associated with CSF biomarker levels of synaptic proteins.
Highlights: A panel of synaptic proteins was quantified in the CSF using mass spectrometry. SV2A ([C]UCB-J) PET was used to quantify synaptic density. Reductions of synaptic density were associated with CSF synaptic biomarker levels.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245979 | PMC |
| http://dx.doi.org/10.1002/alz.70403 | DOI Listing |
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