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Aetiopathogenesis: Sacral fractures represent an often overlooked interface between spinal and pelvic ring injuries. They typically occur in high-energy trauma or in older patients with osteoporosis.
Diagnostics: Due to their complex anatomy and deep location, they are difficult to detect using conventional radiography; thus, computed tomography (CT) is considered the diagnostic gold standard and allows precise fracture analysis. Magnetic resonance imaging (MRI) is particularly valuable for insufficiency or stress-related fractures to detect early bone marrow edema. Biomechanically, the sacrum plays a central role in transmitting load from the trunk to the lower limbs and protects critical neurovascular structures. Fractures can lead to significant instability and neurological deficits, especially when the sacral foramina (Denis zone II) or the sacral canal (Denis zone III) are involved. The AO classification distinguishes between stable (type A), potentially unstable (type B), and spinopelvic unstable (type C) fractures.
Therapy: Therapy depends on fracture type, displacement, and neurological status. Nondisplaced fractures may be treated conservatively, whereas unstable or neurologically symptomatic injuries often require surgical stabilization. A structured radiology report that is understandable across specialties is crucial for effective treatment planning.
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http://dx.doi.org/10.1007/s00117-025-01501-6 | DOI Listing |
Prog Mol Biol Transl Sci
September 2025
Aiiso Yufeng Li Family Department of Chemical and Nanoengineering, University of California, San Diego, La Jolla, CA, United States. Electronic address:
Nano-electronics based neural implants represent a rapidly advancing interdisciplinary domain at the intersection of bioelectronics, nanotechnology, and neuro-engineering. These implantable systems are engineered to restore, modulate, or augment neural functions by establishing high-fidelity, long-term interfaces with neural tissues. The design of such implants necessitates careful consideration of both materials and structural configurations to ensure biocompatibility, mechanical compliance, electrical functionality, and chronic stability.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
Department of Sports Medicine, The First Affiliated Hospital, Guangdong Provincial Key Laboratory of Speed Capability, The Guangzhou Key Laboratory of Precision Orthopedics and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China.
Introduction: During the healing process, the functional gradient attachment of the rotator cuff (RC) tendon-bone interface fails to regenerate, which severely impedes load transfer and stress dissipation, thereby increasing the risk of retears. As a result, the treatment of rotator cuff tears remains a significant clinical challenge.
Methods: In this study, a dual-crosslinked hyaluronic acid/polyethylene glycol (HA/PEG) hydrogel scaffold was synthesized using hyaluronic acid and polyethylene glycol as base materials.
PLoS One
September 2025
Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.
Recent advances in three-dimensional (3D) biological brain models in vitro and ex vivo are creating new opportunities to understand the complexity of neural networks but pose the technological challenge of obtaining high-throughput recordings of electrical activity from multiple sites in 3D at high spatiotemporal resolution. This cannot be achieved using planar multi-electrode arrays (MEAs), which contact just one side of the neural structure. Moreover, the specimen adhesion to planar MEAs limits fluid perfusion along with tissue viability and drug application.
View Article and Find Full Text PDFZhongguo Gu Shang
August 2025
Department of Spinal Surgery, Ningbo No.6 Hospital, Ningbo 315040, Zhejiang, China.
Objective: To establish a two-segment vertebrectomy model using the finite element method, and to measure and compare the biomechanical properties of the lower cervical anterior transpedicular root screw (ATPRS) plate system, lower cervical anterior pedicle screw (ATPS) plate system, and lower cervical anterior cervical locked-plate (ACLP) system on this model.
Methods: CT data of the cervical spine (C-T) from a 34-year-old healthy adult male volunteer were collected. A nonlinear complete model of the lower cervical spine (C-C) was established using Mimics 10.
J Neurochem
September 2025
Institute of Physics, Kazan Federal University, Kazan, Russia.
Neuroimplants are likely major technological breakthroughs of the next decade with the potential for unprecedented social impact. In addition to attractive and miracle-looking possibilities, the major obstacle for the industry is complicated, unpredictable, and unfavorable side effects due to tissue damage, biocompatibility limitations, and foreign body response at the brain-implant interface. Luckily, one major barrier preventing the connection of the neuroimplant to brain cells-the glial scar-has been studied previously for its role in brain trauma.
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