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Introduction: Skin lesion segmentation and classification is an active research area in medical imaging for the large number of reported deaths in the recent years. Early diagnosis of skin cancer is essential to decrease the death rate and increase life expectancy.
Objectives: Several artificial intelligence (AI) based techniques have been introduced in the literature for the diagnosing skin cancer; however, due to challenge of imbalanced datasets, irregular lesion shape, presence of lesions on boundary regions, and selection of inappropriate model selection, the performance of AI model is highly impacted. Therefore, in this work our main objective is to propose a fully automated deep framework for skin lesion segmentation and classification with more efficient and effective way.
Method: This work proposes a novel framework for segmenting and classifying skin lesions using improved ResNet20-DeepLabV3+ and MAKNet100 deep models. In the segmentation task, a ResNet20 architecture is designed as a backbone of DeepLabV3+. In the designed ResNet20 architecture, a few grouped convolutional layers are added with smaller filter sizes to extract more insight information. A new MAKNet100 model is proposed in the classification task based on the network-level fusion of two custom models. The proposed network has few parameters and can extract more information about the lesion images. The proposed model is trained and further analyzed using the GradCAM explainable artificial technique (XAI) as a black box interpretation. Features are extracted from the self-attention layer and passed to classifiers for the final classification.
Results: The experimental process of the proposed framework is performed on HAM10000, ISIC-2018, ISIC-2019, and ISBI-2020 datasets with an accuracy of 90.5 %, 88.9 %, 84.5 %, and 96.35 % respectively and the highest obtained dice score on ISIC-2018 and HAM10000 is 94.63 and 96.69 % respectively.
Conclusion: The proposed framework obtained improved accuracy and precision rates for skin lesion segmentation and classification on these datasets. Moreover, the ablation study and comparison with existing techniques show the proposed framework's dominance.
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http://dx.doi.org/10.1016/j.jare.2025.08.039 | DOI Listing |
Analyst
September 2025
Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Xuzhou, 221004, China.
Mustard agents, including sulphur mustard (SM) and nitrogen mustard (NM), are chemical warfare agents that can cause blistering of the skin and mucous membranes upon contact. Although SM and NM both have dermal effects, their medical management of systemic poisoning differs significantly. A rapid and simple method for detecting and discriminating between SM and NM would be greatly valuable.
View Article and Find Full Text PDFClin Endocrinol (Oxf)
September 2025
Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, China.
Background: Improved cancer survival rates have highlighted second primary malignancies (SPMs), with the thyroid gland being one of the most common organs developing SPMs in cancer survivors. Second primary papillary thyroid carcinoma (2-PTC) is the predominant type, yet it remains poorly understood. This study aims to delineate the clinicopathological features and survival outcomes of 2-PTC and assess the efficacy of postoperative radioactive iodine therapy (post-RAIT) in reducing mortality risks in intermediate-risk 2-PTC patients.
View Article and Find Full Text PDFVirchows Arch
September 2025
Department of Pathology & Laboratory Medicine, Cleveland Clinic Florida, Weston, FL, USA.
Langerhans cell sarcoma (LCS) is an aggressive malignant neoplasm with a Langerhans cell immunophenotype and high-grade cytological features. Occasionally, it can coexist with other hematopoietic neoplasms with proven clonal relationship. Most of these neoplasms were found to be of lymphoid origin.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Dermatology, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China. Electronic address:
Skin aging serves as a critical indicator of systemic health decline. Despite Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) being a key therapeutic target, mechanistic understanding remains incomplete and potent, safe activators are lacking, hindering clinical progress. This study proposes the "Barrier-Skin-Systemic Aging Axis," demonstrating that epidermal barrier disruption accelerates aging via PPARγ suppression.
View Article and Find Full Text PDFJ Am Acad Dermatol
September 2025
Department of Pharmacology and Toxicology; Department of Dermatology, Boonshoft School of Medicine at Wright State University, Dayton, Ohio; Department of Dayton V.A. Medical Center, Dayton, Ohio. Electronic address: