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Introduction Poor physical performance is associated with an increased risk of post-discharge cardiovascular events in patients with heart failure. In this study, we investigated the association between physical frailty and improvements in physical performance through cardiac rehabilitation in hospitalized older patients with heart failure. Methods The study included 100 patients with heart failure (aged ≥65 years) hospitalized between January 2023 and August 2024, with a short physical performance battery (SPPB) score ranging from 1 to 11 points at the initiation of cardiac rehabilitation. Patients achieving an improvement of ≥1 SPPB points during hospitalization were classified as the improved group, while those with unchanged or declining scores comprised the non-improved group. We retrospectively examined the association between physical frailty and improvement in physical performance due to acute-phase cardiac rehabilitation during hospitalization. Results Among the 100 patients, 62 and 38 were categorized into the improved and non-improved groups, respectively. Although no significant differences were observed regarding age, sex, or rehabilitation duration between the groups, the prevalence of physical frailty was significantly higher in the non-improved than in the improved group. Modified Poisson regression analysis, controlling for age, sex, and New York Heart Association functional class, showed that physical frailty was significantly associated with a reduced likelihood of improvement in physical performance. Conclusion Physical frailty may inhibit improvement in physical performance among hospitalized older patients with heart failure. Therefore, enhancing acute-phase rehabilitation strategies for patients with frailty and strengthening the post-discharge follow-up system are essential.
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http://dx.doi.org/10.7759/cureus.88846 | DOI Listing |
J Mater Chem B
September 2025
Major in Bionano Engineering, School of Bio-Pharmaceutical Convergence, Hanyang University, Ansan, 155-88, Republic of Korea.
Membrane proteins are essential bio-macromolecules involved in numerous critical biological processes and serve as therapeutic targets for a wide range of modern pharmaceuticals. Small amphipathic molecules, called detergents or surfactants, are widely used for the isolation and structural characterization of these proteins. A key requirement for such studies is their ability to maintain membrane protein stability in aqueous solution, a task where conventional detergents often fall short.
View Article and Find Full Text PDFAnn Geriatr Med Res
September 2025
Institute of Health and Sport Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
Background: Poor hand dexterity may increase the risk of functional disability; however, few studies have examined the relationship between hand dexterity and incident functional disability. The aim of this study was to prospectively investigate the dose-response association of hand dexterity with incident functional disability in community-dwelling older adults.
Methods: This study included 1,069 older adults aged ≥65 years in Kasama City, Japan.
Mater Horiz
September 2025
New Cornerstone Science Laboratory, State Key Laboratory for Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, China.
Dispersing iridium onto high-specific-surface-area supports is a widely adopted strategy to maximize iridium utilization in anode catalysts of proton exchange membrane water electrolysis (PEMWE). However, here we demonstrate that the overall cell performance, including initial efficiency and long-term stability, does not benefit from the typical high specific surface area of catalyst supports. The conventional understanding that high iridium utilization on high-specific-surface-area supports increases activity holds only in aqueous electrolytes, while under the typical working conditions of PEMWE, the mass transport within the anode catalyst layers plays a more significant role in the overall performance.
View Article and Find Full Text PDFDalton Trans
September 2025
University of Belgrade, Faculty of Physical Chemistry, Studentski trg 12-16, 11158 Belgrade, Serbia.
Developing efficient, low-cost catalysts for oxygen reduction and evolution reactions (ORR and OER) is key to advancing metal-air batteries and regenerative fuel cells. In this study, nitrogen-doped binary metal (Mn and Ni) oxides (N-BMOs) and Pt-decorated N-BMOs were synthesised using three methods and tested as ORR and OER catalysts in alkaline media. Their physicochemical properties were characterised by XRD, N-sorption, TEM, and XPS, while their electrochemical performance was evaluated using voltammetry and impedance spectroscopy.
View Article and Find Full Text PDFDalton Trans
September 2025
School of Education, Can Tho University, 3-2 Road, Can Tho City 900000, Vietnam.
Enhancement of the performance of lithium-ion batteries is a critical strategy for addressing the challenges associated with cost and raw materials. By doping boron (B), aluminum (Al), and aluminum/boron (Al/B) utilizing the sol-gel method, we demonstrate a substantial improvement in the cycling performance of Ni-rich lithium nickel manganese cobalt oxide (NMC) as an electrode. While the initial specific capacitance of the doped samples may be lower than that of the pristine NMC, these samples demonstrate a notable increase in specific capacitance during subsequent cycles, reaching a peak around the 10 cycle and nearing the highest specific capacitance observed in NMC cathodes.
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