Tailoring butane-1,2,3,4-tetraol-based maltosides (BTMs) group-swapping and detergent unsymmetry: new detergent design strategies for membrane protein studies.

Membrane proteins are essential bio-macromolecules involved in numerous critical biological processes and serve as therapeutic targets for a wide range of modern pharmaceuticals. Small amphipathic molecules, called detergents or surfactants, are widely used for the isolation and structural characterization of these proteins. A key requirement for such studies is their ability to maintain membrane protein stability in aqueous solution, a task where conventional detergents often fall short.

Drug-coated balloons for the treatment of in-stent restenosis: an updated systematic review and meta-analysis of randomized controlled trials.

Background: Drug-coated balloons (DCBs) have emerged as a potential option for treating in-stent restenosis (ISR). We aimed to assess the efficacy and safety of DCB compared to uncoated balloons (UCBs) for patients with ISR.

Methods: We systematically searched Embase, MEDLINE, and Cochrane Library for randomized controlled trials comparing drug-coated balloons with uncoated balloons for coronary in-stent restenosis (ISR).

Enteral vitamin a supplementation for the prevention of bronchopulmonary dysplasia in preterm infants: an updated systematic review and meta-analysis.

Material And Methods: We searched several databases using Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and ClinicalTrials.gov. We included only placebo-controlled clinical trials on infants born at less than 32 weeks' gestation, who were administered enteral vitamin A supplementation.

Evaluating long-term outcomes and the impact of small aortic annulus on valve replacement-a novel systematic review and meta-analysis comparing surgery vs. transcatheter interventions.

Background: Transcatheter aortic valve implantation (TAVI) is often compared to surgical aortic valve replacement (SAVR) for aortic stenosis treatment. This meta-analysis evaluates the long-term efficacy and safety of TAVI vs. SAVR in aortic stenosis patients, as well as their respective impact on patients with small aortic annulus (SAA).

Radiation-Induced Cardiac Disease: Dilemma of Transcatheter Aortic Valve Replacement vs Surgical Aortic Valve Replacement and Pericardiectomy.

Background: Radiation-induced cardiovascular disease, a complication of mediastinal radiation, often results in valvular and pericardial disease. Management is challenging, especially in high-risk patients.

Case Summary: A 59-year-old man with a history of total body radiation presented with fatigue and dyspnea.

Comparative Efficacy and Safety of Colchicine and Anti-Interleukin-1 Agents in Recurrent Pericarditis: A Pairwise and Network Meta-Analysis of Randomized Controlled Trials.

Background: The management of recurrent pericarditis includes colchicine and anti-interleukin-1 agents, given the limited efficacy and adverse effects of NSAIDs and corticosteroids. We conducted a pairwise and network meta-analysis to evaluate the efficacy and safety of colchicine and anti-interleukin-1 agents in recurrent pericarditis.

Methods: We conducted a comprehensive search on various databases to retrieve relevant randomized controlled trials.

Multiscale Insights into Structure-Porosity Interplay and Water Adsorption in Granular Activated Carbon for Enhanced Electrochemical Water Treatment.

Granular activated carbon (GAC) has proven to be a highly effective material for electrochemical water treatment due to its large surface area and porous structure. This study presents a multiscale investigation combining molecular dynamics (MD) simulations, continuum-scale modeling, and experimental validation to understand how the GAC structure influences water adsorption and reactivity. MD simulations show that highly porous GAC (porosity up to 0.

Cardiac myosin inhibitors for hypertrophic cardiomyopathy: a systematic review and meta-analysis of randomized controlled trials.

Background/objective: HCM is a structural disorder of the myocardium that leads to sudden cardiac death in young adults. We synthesized an updated understanding of the role of Cardiac Myosin Inhibitors (CMIs) in HCM by pooling data from RCTs.

Methods: We identified six published RCTs, involving 826 participants.

Dual- vs. Single-Antibiotic Loaded Cement for Hip Hemiarthroplasty: A Systematic Review and Meta-Analysis.

Background: Antibiotic-loaded cement (ALC) is often used to reduce the risk of surgical site infections (SSIs) in hip hemiarthroplasty; however, controversy exists regarding the use of dual antibiotic-loaded cement (DALC) and single antibiotic-loaded cement (SALC).

Objective: This systematic review and meta-analysis compare the efficacy of DALC and SALC for hip hemiarthroplasty.

Methods: For this systematic review, a search was undertaken in the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and ClinicalTrials.

Compression-only or standard cardiopulmonary resuscitation for out-of-hospital cardiac arrest: a systematic review and meta-analysis of randomized controlled trials.

This meta-analysis aims to compare chest compression-only cardiopulmonary resuscitation (CO-CPR) with standard CPR (sCPR), which includes mouth-to-mouth ventilation, as potential strategies for managing out-of-hospital cardiac arrest (OHCA). We systematically searched various databases and registries such as MEDLINE, Embase, The Cochrane Library, and Clinicaltrials.gov to retrieve relevant studies.

Efficacy and safety of SGLT2 inhibitors in acute heart failure: a systematic review and meta-analysis of randomized controlled trials.

Background: Acute heart failure (AHF) is a serious medical condition with considerable morbidity and mortality ranging from 20%-30% within the first month following hospital admission. We aimed to evaluate the efficacy and safety of sodium-glucose cotransporter-2 (SGLT2) inhibitors administered within the first five days of hospitalization for AHF.

Methods: We utilized various electronic resources such as MEDLINE, Embase, and the Cochrane Library to retrieve relevant randomized controlled trials (RCTs).

Appraisal of groundwater conditions through hydrogeophysical and hydrogeological approach in Cholistan area, district Bahawalpur, Punjab, Pakistan.

The sustainable groundwater supply has a prime importance for the development of an area. Unfortunately, the groundwater-related issues are heading towards terrible situation regionally and locally as well. As far as the different parts of Punjab Province of Pakistan are concerned, Cholistan is almost a desert region where the groundwater scarcity is being observed in its different parts since decades.

Transformer-based deep learning enables improved B-cell epitope prediction in parasitic pathogens: A proof-of-concept study on Fasciola hepatica.

Background: The identification of B-cell epitopes (BCEs) is fundamental to advancing epitope-based vaccine design, therapeutic antibody development, and diagnostics, such as in neglected tropical diseases caused by parasitic pathogens. However, the structural complexity of parasite antigens and the high cost of experimental validation present certain challenges. Advances in Artificial Intelligence (AI)-driven protein engineering, particularly through machine learning and deep learning, offer efficient solutions to enhance prediction accuracy and reduce experimental costs.

Electrochemical activation of alum sludge for the adsorption of lead (Pb(II)) and arsenic (As): Mechanistic insights and machine learning (ML) analysis.

Alum sludge (AlS) has emerged as an effective adsorbent for anionic contaminants, with traditional activation methods like acid/base treatments and calcination employed to enhance its adsorption capacity. However, these approaches encounter significant drawbacks, including excessive waste generation, structural degradation, and limited efficacy for cationic contaminants. To overcome these challenges, this study proposes electrochemical activation as a sustainable method to enhance alum sludge adsorption performance by generating oxygen-containing functional groups (O-FGs) on its surface.

Tenecteplase versus alteplase in patients with acute ischemic stroke: An updated meta-analysis of randomized controlled trials.

Introduction: Acute ischemic stroke (AIS) is a leading cause of morbidity and mortality worldwide. While alteplase has been widely used for acute management, recent clinical trials suggest that tenecteplase (TNK) may offer improved clinical outcomes. This study aims to compare the efficacy and safety of TNK compared with alteplase.

Multiple Pendants-Bearing Triglucosides for Membrane Protein Studies: Effects of Pendant Length and Number on Micelle Interior Hydration and Protein Stability.

Membrane proteins play central roles in cell physiology and are the targets of over 50% of FDA-approved drugs. In the present study, we prepared single alkyl-chained triglucosides decorated with multiple pendants, designated multiple pendant-bearing glucosides (MPGs), to enhance membrane protein stability. The new detergents feature two and four pendants of varying size at the hydrophilic-lipophilic interfaces, designated MPG-Ds and MPG-Ts, respectively.

The impact of increasing Zr dopant concentration in Ruddlesden Popper perovskite to enhance Resistive Random-Access Memory performance: Using the DFT method.

As Resistive Random- Access memory (RRAM) emerges as a promising solution for high-performance memory application, this study applies density functional theory (DFT) to analyze the structural, electronic, and optical properties of pure and Zr-doped MgHfO at various doping concentrations (0, 0.25, 0.50, 0.

More intensive versus conservative blood pressure lowering after endovascular therapy in stroke: a meta-analysis of randomised controlled trials.

Background: The optimum systolic blood pressure (BP) after endovascular thrombectomy for acute ischaemic stroke is uncertain. We aimed to perform an updated meta-analysis of randomised controlled trials (RCTs) to evaluate the safety and efficacy of more intensive BP management compared to less intensive BP management.

Methods: We searched various electronic databases to retrieve relevant RCTs on the clinical effects of more intensive BP management after endovascular thrombectomy compared to the less intensive management.

Simultaneous removal of Cr(VI), As(III), and sulfanilamide via an e-barrier electrochemical system: A pilot study.

In-situ electrochemical remediation has emerged as a promising groundwater remediation technology. However, its application has been limited to short-term decontamination. Here, we propose an electrochemical system that combines an e-barrier with pyrite, a sulfide mineral capable of completely removing As(III), Cr(VI), and sulfanilamide continuously for one year.

Environmentally Sustainable and Green Polymeric Method for Chitosan (CH) Film Synthesis Using Natural Acids and Impact of Zinc Ferrite Nanoparticles (NPs) on Water Solubility (WS) and Physical Properties.

Currently, there is a rush to develop green polymeric films such as biodegradable chitosan (CH) films to control and prevent plastic pollution from degrading the environment. This study reports a novel and sustainable green approach to the development of CH films using lemon juice (LJ) and lemon peel extract (LPE), the latter to dilute the LJ. The LPE was also utilized for the synthesis of ZnFeO nanoparticles (NPs), adding to this work's novelty.

The Impact of Nickel-Zinc Ferrite Nanoparticles on the Mechanical and Barrier Properties of Green-Synthesized Chitosan Films Produced Using Natural Juices.

A trend has been established concerning the research and development of various green and biodegradable plastics for multi-purpose applications, aiming to replace petroleum-based plastics. Herein, we report the synthesis of chitosan (CH) films using lemon juice; these were reinforced with NiZnFeO nanoparticles (NiZnFeO NPs) to obtain improved mechanical and barrier properties, facilitating their future application as sustainable, corrosion-resistant coatings for medical instruments. The synthesized NiZnFeO NPs had a crystallite size of ~29 nm.

Aggressive Versus Moderate Fluid Replacement for Acute Pancreatitis: An Updated Systematic Review and Meta-Analysis.

Background: A conservative strategy is the primary modality of treatment for acute pancreatitis of which fluid replacement is an important component. Since the results regarding early aggressive versus moderate fluid replenishment for acute pancreatitis are inconsistent, we sought to compare outcomes between the two resuscitation strategies in our meta-analysis.

Methods: We searched MEDLINE (PubMed), Embase, the Cochrane Library, and ClinicalTrials.

Electrochemical ocean iron fertilization and alkalinity enhancement approach toward CO sequestration.

Achieving net-zero emissions by 2050 requires the development of effective negative emission techniques, including ocean-based approaches for CO sequestration. However, the implementation and testing of marine CO removal (mCDR) techniques such as ocean iron fertilization (OIF) or ocean alkalinity enhancement (OAE) face significant challenges. Herein, a novel self-operating electrochemical technology is presented that not only combines OIF and OAE, but also recovers hydrogen gas (H) from seawater, hence offering a promising solution for achieving quantifiable and transparent large-scale mCDR.

Nanoparticle containing recombinant excretory/secretory-24 protein of enhanced the cellular immune responses in mice.

poses a global challenge as a parasite affecting small ruminants, yet the problem of absence of an effective vaccine against infection still exists. This investigation sought to appraise the immunological reaction induced by recombinant excretory/secretory-24 (rHcES-24) in combination with complete Freund's adjuvant (CFA) and bio-polymeric nanoparticles (NPs) within a murine model. In this study, rHcES-24 was encapsulated in poly(d, l-lactide-co-glycolide) (PLGA) and chitosan (CS) NPs, administered subcutaneously to mice.