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This paper is about the design and fabrication of infrared lenses, which are the core components of thermal imaging cameras to be mounted on vehicles. To produce an athermalized optical system, chalcogenide glass (AsSe) with a lower thermo-optic coefficient () than germanium was adopted as a lens material, and each lens was designed so that defocus occurs in opposite directions depending on temperature. The designed lens was fabricated using a compression molding method, and the molded lenses showed less than 1.5 μm of form error (PV) using a mold iteration process. Through evaluations of MTF and thermal images obtained from the lens module, it was judged that this optical design process is obtainable.
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http://dx.doi.org/10.3390/mi16080901 | DOI Listing |
EMBO Mol Med
September 2025
State Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical Sciences, 100071, Beijing, China.
Traditional live attenuated vaccines (LAVs) are typically developed through serial passaging or genetic engineering to introduce specific mutations or deletions. While viral RNA secondary or tertiary structures have been well-documented for their multiple functions, including binding with specific host proteins, their potential for LAV design remains largely unexplored. Herein, using Zika virus (ZIKV) as a model, we demonstrate that targeted disruption of the primary sequence or tertiary structure of a specific viral RNA element responsible for Musashi-1 (MSI1) binding leads to a tissue-specific attenuation phenotype in multiple animal models.
View Article and Find Full Text PDFMicrosyst Nanoeng
September 2025
Department of Ophthalmology, Key Laboratory of Precision Medicine for Eye Diseases of Zhejiang Province, Center for Rehabilitation Medicine,, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, 314408, China.
Retinal surgery is one of the most delicate and complex operations, which is close to or even beyond the physiological limitation of the human hand. Robots have demonstrated the ability to filter hand tremors and motion scaling which has a promising output in microsurgery. Here, we present a novel soft micron accuracy robot (SMAR) for retinal surgery and achieve a more precise and safer operation.
View Article and Find Full Text PDFNat Commun
September 2025
Shanghai Yao Yuan Biotechnology Ltd (Drug Farm), Shanghai, China.
ROSAH (retinal dystrophy, optic nerve edema, splenomegaly, anhidrosis, and headache) syndrome is a rare genetic disease caused by variants in alpha-kinase 1 (ALPK1) resulting in downstream pro-inflammatory signaling mediated by the TIFA/TRAF6/NF-κB pathway. Here, we report the design of an ALPK1 inhibitor, DF-003, with pharmacokinetic properties suitable for daily oral dosing. In biochemical assays, DF-003 potently inhibits human ALPK1 (IC = 1.
View Article and Find Full Text PDFLight Sci Appl
September 2025
Key Lab of Environmental Optics & Technology, Anhui Institute of Optics and Fine Mechanics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, 230031, Hefei, China.
Marine vessels play a vital role in the global economy; however, their negative impact on the marine atmospheric environment is a growing concern. Quantifying marine vessel emissions is an essential prerequisite for controlling these emissions and improving the marine atmospheric environment. Optical imaging remote sensing is a vital technique for quantifying marine vessel emissions.
View Article and Find Full Text PDFJ Chem Inf Model
September 2025
Department of Chemistry and Biochemistry, University of Arizona, Tucson, Arizona 85721-0041, United States.
The development of low-cost, high-performance materials with enhanced transparency in the long-wavelength infrared (LWIR) region (800-1250 cm/8-12.5 μm) is essential for advancing thermal imaging and sensing technologies. Traditional LWIR optics rely on costly inorganic materials, limiting their broader deployment.
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