Research Strategies and Methods of Hydrogels for Antitumor Drug Delivery.

Biomedicines

Research Center for Macromolecules and Biomaterials, National Institute for Materials Science, Namiki 1-1, Tsukuba 305-0044, Ibaraki, Japan.

Published: August 2025


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Article Abstract

Tumor treatments have substantially advanced through various approaches, including chemotherapy, radiotherapy, immunotherapy, and gene therapy. However, efficient treatment necessitates overcoming physiological barriers that impede the delivery of therapeutic agents to target sites. Drug delivery systems (DDSs) are a prominent research area, particularly in tumor therapy. This review provides a comprehensive overview of hydrogel-based DDSs for tumor treatment, focusing on the strategies and designs of DDSs based on the unique pathophysiological characteristics of tumors. The design and preparation of hydrogel systems for DDSs are summarized and highlighted. The challenges and opportunities for translating hydrogel-based DDSs into clinical applications are discussed.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12383573PMC
http://dx.doi.org/10.3390/biomedicines13081899DOI Listing

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