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| http://dx.doi.org/10.1016/j.jinf.2025.106602 | DOI Listing |
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New insights to B cell tolerance involving the mechanosensitive ion channel Piezo1.
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Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; Brain Korea 21 PLUS Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea; Institute for Immunology and Immunological Diseases, Yonsei Uni
B cell tolerance is critical for preventing autoimmunity, yet the mechanisms by which B cells discriminate self from non-self antigens remain incompletely understood. While early findings emphasize the role of classical antigen-mediated BCR signaling strength by varying antigen formats, emerging evidence highlights the importance of mechanical cues during antigen recognition. This review explores how mechanosensitive ion channels, particularly Piezo1, contribute to B cell activation and tolerance by integrating physical forces at the immune synapse.
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