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Background: Changes in age-related trends in joint arthroplasty have a significant impact on surgical prognosis and resource allocation. Though these trends have been documented in several high-income countries, the rapid aging process and relatively backward development of joint arthroplasty may shape a different pattern in China. Therefore, we aimed to determine the age-related trends in total knee arthroplasty (TKA) and total hip arthroplasty (THA) in China.
Methods: Patients receiving TKA or THA between 2013 and 2019 were identified from the national inpatient database. A total of 200,478 patients receiving TKA and 161,068 patients receiving THA were included. Poisson regression analyses were used to assess trends in mean age and the proportion of patients across different age groups. The rural-urban and regional disparities in the mean age and proportion of patients over 60 years were compared using Student's t-tests and Chi-square tests.
Results: During the study period, the mean age significantly increased from 66 to 67 years for TKA and from 56 to 58 years for THA (P for trend < 0.001). The proportion of patients over 60 years increased from 79.1 to 85.6% for TKA and from 43.4 to 48.5% for THA (P for trend < 0.001). Rural-urban and regional variations in age structure were observed, with higher mean ages and a greater proportion of patients over 60 years in urban areas and Eastern China (P < 0.001). Additionally, the mean age and the proportion of patients over 60 years continued to increase in those receiving cross-regional healthcare.
Conclusion: There has been a significant increase in the mean age and the proportion of patients over 60 years undergoing TKA and THA in China, along with notable regional and rural-urban disparities. Greater efforts are needed to meet the growing demand for arthroplasty and to reallocate medical resources.
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http://dx.doi.org/10.1016/j.arth.2025.08.056 | DOI Listing |
Semin Dial
September 2025
Department of Nephrology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Background: In hyponatremic patients, concurrent dialysate flow during hemodialysis may be an ideal option to mitigate complications such as osmotic demyelination syndrome (ODS).
Methods: Present randomized controlled trial enrolled dialysis-requiring chronic kidney disease (CKD) and acute kidney injury (AKI) patients with serum sodium levels < 125 mEq/L during January 2020 over 16 months. Hemodynamically unstable patients, as well as those with a history of seizures and neurological conditions, were excluded.
Ann Surg Oncol
September 2025
Department of Thoracic Surgery, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian Province, China.
Background: RUNX3 acts as a tumor suppressor gene in non-small-cell lung cancer (NSCLC), yet its specific biological mechanism is still unclear. This study aimed to uncover tumor microenvironment (TME) changes in NSCLC with varying RUNX3 expression statuses through single-cell RNA sequencing.
Patients And Methods: In total, seven patients with NSCLC with detailed pathological data were involved, with three both paracancerous and cancerous tissue samples.
J Nucl Cardiol
September 2025
Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA. Electronic address:
Background: Cardiac positron emission tomography (PET) and single-photon emission computed tomography (SPECT) are widely used for the assessment of coronary artery disease. While SPECT remains more available, workforce shortages and training demands contribute to geographic disparities in PET availability, impacting patient access to advanced imaging. Therefore, we assessed trends in the U.
View Article and Find Full Text PDFBest Pract Res Clin Haematol
September 2025
Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
With upfront use of triplet- and quadruplet-based regimens coupled with autologous stem cell transplant (ASCT) and maintenance lenalidomide, a high proportion of multiple myeloma (MM) patients are achieving deep and durable responses. Yet, myeloma invariably relapses, with refractoriness to one or more drugs at first relapse. This therapeutic gap has been partially filled by T-cell engager (TCE) therapies that have demonstrated remarkable response rates and prolonged remissions in heavily pretreated patients with MM, providing off-the-shelf immunotherapy options leading to the U.
View Article and Find Full Text PDFPharmacoepidemiol Drug Saf
September 2025
TriNetX, LLC, Cambridge, Massachusetts, USA.
Introduction: Many clinical data networks often focus on a single use-case or disease. By contrast, the TriNetX Dataworks-USA Network contains real-world clinical information that can be applied to multiple research questions and use cases. The purpose of this study is to describe the Network's characteristics, as well as its generalizability to the US population, particularly the healthcare-seeking population.
View Article and Find Full Text PDF