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Non-invasive health monitoring technologies increasingly attract attention as they allow for continuous, comfortable vital sign monitoring. However, contactless sensing of vital signs using radar systems has significant challenges in accurately extracting physiological information from noisy signals, especially when subjects move freely. This study introduces a novel framework that combines Independent Component Analysis (ICA) and Empirical Wavelet Transform (EWT) to estimate respiratory rate (RR) from radar signals under free-movement conditions. ICA automatically selected physiologically relevant components from the radar signals. Subsequently, the Empirical Wavelet Transform served as an adaptive Multi-Resolution Analysis (MRA) technique, effectively decomposing and reconstructing respiratory signals to improve peak detection accuracy. We evaluated the proposed framework using experimental data from ten subjects performing activities that mimic daily life in a living laboratory environment. A TMSi MOBi8 system recorded the reference RR signals simultaneously. Performance evaluation using Pearson's correlation coefficient revealed a strong correlation (r = 0.94) for the best-performing method. At the same time, the Bland-Altman analysis showed a mean error of -0.41 breaths per minute, demonstrating the ICA-EWT framework's effectiveness in estimating RR in freely moving real-world settings. However, addressing issues related to radar placement and signal interference is suggested to improve the method's accuracy.
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http://dx.doi.org/10.1016/j.compbiomed.2025.110957 | DOI Listing |
Pathol Res Pract
September 2025
Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:
Our research aims to ascertain the value of precursor and outgrowth lepidic in aiding the confirmation of multiple lung adenocarcinomas as separate primary lung cancers (SPLC). A total of 151 patients with metachronous multiple invasive adenocarcinomas were included in this study. Driver mutation tests(at least five genes: EGFR, ALK, KRAS, BRAF, and ROS1) were conducted on 302 tumors collected from 151 patients.
View Article and Find Full Text PDFJ Bras Pneumol
September 2025
. Santa Casa de Misericórdia de Mogi Mirim, Mogi Mirim (SP) Brasil.
Objective: Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in older adults, particularly those with comorbidities. Despite its clinical impact, RSV remains underdiagnosed and underreported. We sought to assess the burden of RSV in older adults (≥ 60 years of age) in Brazil using national surveillance data for the 2022-2023 period.
View Article and Find Full Text PDFAm J Physiol Regul Integr Comp Physiol
September 2025
Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, ON, Canada.
to explore sex and heating rate effects on frequency-domain indicators of the mechanisms modulating cutaneous vasodilation during local heating. In thirty young adults (21±3 years, 15 females), wavelet analysis of skin blood flux was assessed from laser-Doppler flux signals at the chest, abdomen, arm, forearm, thigh, and calf during rapid (33-42°C; 1°C·20 s) and gradual (33-42°C; 1°C·5 min) local skin heating. A wavelet transform using a Morlet mother wavelet was computed over the entire signal for each heating protocol (minimum 90 minutes) and 5-min time windows were subsequently isolated to determine responses during baseline and the 42°C heating plateau.
View Article and Find Full Text PDFJ Proteome Res
September 2025
Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Colorectal cancer (CRC) is a major global health challenge due to its high incidence, mortality, and low rate of early detection. Early diagnosis, targeting precancerous lesions (advanced adenomas) and early stage CRC (Tis and T1), is critical for improving patient survival. Given the limitations of current detection methods for advanced adenomas, developing high-performance early diagnostic strategies is essential for effective prevention.
View Article and Find Full Text PDFInt J Pharm X
June 2025
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325015, China.
Ultra-sensitive pH-responsive drug delivery system designed to operate within the slightly acidic microenvironment of tumors are highly desired for hydrogel applications in cancer therapy. In this study, 4-Formylbenzoic acid modified polyvinyl alcohol (PVA-FBA, PF) was synthesized and utilized as a carrier for encapsulating the anticancer drug Doxorubicin (Dox). This was subsequently crosslinked with polyethylenimine (PEI) via benzoic-imine bond to form drug-loaded PVA-FBA/PEI hydrogel (D-PFP).
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