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The Kibble-Zurek (KZ) mechanism renders a theoretical framework for elucidating the formation of topological defects across continuous phase transitions. Nevertheless, it is not immediately clear whether the KZ mechanism applies to topological phase transitions. The direct experimental study for such a topic is hindered by quenching a certain parameter over orders of magnitude in topological materials. Instead, we investigate the KZ behavior across topological transitions of a Chern band in two-dimensional (2D) optical Raman lattices with quantum gases. Defined as the defects, excitation density is reconstructed via measuring the spin wave functions, with which the power-law scaling of total excitation density is extracted and such scaling could be interpreted within the KZ framework. Our work has heralded the commencement of experimentally exploring the KZ mechanism of the topological phase transitions.
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http://dx.doi.org/10.1103/5j5s-946k | DOI Listing |
Int J Biol Macromol
September 2025
National Demonstration Center for Experimental Fisheries Science Education (Shanghai Ocean University), Shanghai, 201306, China; Key Laboratory of Exploration and Utilization of Aquatic Genetic Resources (Shanghai Ocean University), Ministry of Education, Shanghai, 201306, China; International Resea
Phase separation has been discovered as a new form of regulation in innate immunity. Here, we found that IL6Ra in teleost fish has a unique intrinsic disordered region (IDR) in its amino acid sequence, distinguishing it from the IL6Ra of higher vertebrates. This unique feature endows IL6Ra with the ability to undergo liquid-liquid phase separation, enabling the organism to swiftly initiate an immune response at the early stages of viral infection.
View Article and Find Full Text PDFJ Colloid Interface Sci
September 2025
Key Laboratory of Urban Rail Transit Intelligent Operation and Maintenance Technology & Equipment of Zhejiang Province, College of Engineering, Zhejiang Normal University, Jinhua 321004, China. Electronic address:
Developing high-performance wearable flexible sensors that can adapt well to complex environments has become a hotspot. Herein, a polyvinyl alcohol based composite hydrogel sensor with high mechanical strength, desirable frost/swelling resistance, and highly sensitive sensing performance was proposed by a multi-component collaborative design strategy. Meanwhile, an intelligent gesture recognition system was established by combining machine learning algorithm.
View Article and Find Full Text PDFBlood Adv
September 2025
Alfred Health and Monash University, East Melbourne, Australia.
Zanubrutinib is a next-generation covalent Bruton tyrosine kinase (BTK) inhibitor designed to provide complete and sustained BTK occupancy for efficacy across disease-relevant tissues, with fewer off-target adverse events (AEs) than other covalent BTK inhibitors. In the phase 3 ASPEN study (BGB-3111-302), comparable efficacy and a favorable safety profile versus ibrutinib were demonstrated in patients with MYD88-mutated Waldenström macroglobulinemia (WM), leading to approval of zanubrutinib for patients with WM. BGB-3111-LTE1 (LTE1) is a long-term extension study to which eligible patients, including patients from comparator treatment arms, could enroll following participation in various parent studies of zanubrutinib to treat B-cell malignancies.
View Article and Find Full Text PDFKhirurgiia (Mosk)
September 2025
Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus.
Objective: To evaluate clinical and laboratory effectiveness of ultrasound treatment for purulent wounds.
Material And Methods: The study enrolled 46 patients with purulent wounds divided into the main group (23 patients, ultrasonic treatment) and the control group (23 patients, traditional treatment). We assessed treatment effectiveness considering visual data, quality of granulation tissue, wound defect area and marginal epithelialization, complete blood count and C-reactive protein.
Climacteric
September 2025
Gynecology Discipline, Obstetrics and Gynecology Department, University of São Paulo School of Medicine, São Paulo, Brazil.
Objective: Social media is an increasingly relevant tool for health education, enabling information exchange, promoting autonomy and supporting informed decision-making. This study introduces Menopausando, a predominantly Portuguese-language digital platform designed to support women during menopausal transition and postmenopause.
Method: This cross-sectional study has been carried out in the Gynecology Discipline, São Paulo University, Brazil, since 2019.