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Traditional brain emulation approaches often rely on classical computational models that inadequately capture the stochastic, nonlinear, and potentially coherent features of biological neural systems. In this position paper, we introduce NeuroQ a quantum-inspired framework grounded in stochastic mechanics, particularly Nelson's formulation. By reformulating the FitzHugh-Nagumo neuron model with structured noise, we derive a Schrödinger-like equation that encodes membrane dynamics in a quantum-like formalism. This formulation enables the use of quantum simulation strategies-including Hamiltonian encoding, variational eigensolvers, and continuous-variable models-for neural emulation. We outline a conceptual roadmap for implementing NeuroQ on near-term quantum platforms and discuss its broader implications for neuromorphic quantum hardware, artificial consciousness, and time-symmetric cognitive architectures. Rather than demonstrating a working prototype, this work aims to establish a coherent theoretical foundation for future research in quantum brain emulation.
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http://dx.doi.org/10.3390/biomimetics10080516 | DOI Listing |
Chaos
September 2025
School of Science, Jiangxi University of Science and Technology, Ganzhou 341000, China.
Synaptic plasticity is of great significance for understanding the leaning and memory processes in different brain regions since it determines the synchronized firing activities of neurons. A volatility-switchable memristor-coupled heterogeneous neuron model is proposed to explore the effects of the synaptic plasticity on the synchronous dynamics of coupled neurons in different brain regions. With the increment of the non-volatility, the critical coupling strength of synchronization between two heterogeneous neurons decreases in a power-law relationship with the character parameter of the memristor.
View Article and Find Full Text PDFFront Bioeng Biotechnol
August 2025
NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, China.
Cerebral ischemic stroke (CIS) is a severe cerebrovascular disease that poses numerous challenges in diagnosis and treatment, primarily attributed to blood-brain barrier (BBB) constraints and inherent drug targeting limitations. Biomimetic membrane nanotechnology, as an emerging therapeutic approach, offers a novel therapeutic strategy by emulating biological membrane structures and functions. This review comprehensively examines biomimetic nanomedicines (BMNPs) in CIS management, encompassing preparation methodologies, material characterization, and specific diagnostic/therapeutic applications.
View Article and Find Full Text PDFJ Neurol Neurosurg Psychiatry
September 2025
Hospices Civils de Lyon, Service de Neurologie, sclérose en plaques, pathologies de la myéline et neuroinflammation, Bron, France.
Unlabelled: BackgroundTarget trial emulation (TTE) offers a formal framework for causal inference using observational data, but its validity must be evaluated in each research domain by replicating randomised clinical trials (RCTs). We aimed to replicate eight RCTs evaluating the efficacy of disease-modifying therapies (DMTs) in multiple sclerosis (MS) using French registry data.
Methods: This multicentre, retrospective, observational study was conducted using data extracted in December 2023 from the (OFSEP) database.
Adv Sci (Weinh)
August 2025
School of Biological and Chemical Sciences, College of Science and Engineering, University of Galway, University Road, Galway, H91 TK33, Ireland.
Cerebral organoids (COs) are multicellular, self-organized, in vitro, 3D brain-like tissues used for developmental biology, disease modelling, and drug screening. However, their lack of vascularity renders them less physiologically accurate. Vascularization of COs remains challenging due to the different requirements between COs and vascular cells, limited vascular network penetration within the organoid, and the absence of luminal perfusion.
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