98%
921
2 minutes
20
This article reviews Loet Leydesdorff's contributions to science mapping. It explains how over the years, his mapping techniques evolved from journal mapping to global maps of science and finally towards interactive interfaces portraying multiple classifications and ontologies. It then critically reviews the challenges faced by current approaches to science mapping, which implicitly assume a 'natural' epistemic structure, with examples from two recent case studies. We observe that bottom-up algorithmic approaches, either based on citation or semantic approaches, lack conceptual consistency regarding the type of categories used: in a same classification a category captures methods, another one has materials, a third one contains empirical objects and a fourth is focused on theories, rather than having a single logic. I argue that science mapping would produce more useful representations by using ontologies based on a single logic that aligns with the particular conceptual needs of the analysis. Novel classification methods based on machine learning and language models hold promise to produce these tailored, question-driven ontologies.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12367962 | PMC |
http://dx.doi.org/10.1007/s11192-025-05323-0 | DOI Listing |
Clin Genet
September 2025
Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
LONP1 encodes a mitochondrial protease essential for protein quality control and metabolism. Variants in LONP1 are associated with a diverse and expanding spectrum of disorders, including Cerebral, Ocular, Dental, Auricular, and Skeletal anomalies syndrome (CODAS), congenital diaphragmatic hernia (CDH), and neurodevelopmental disorders (NDD), with some individuals exhibiting features of mitochondrial encephalopathy. We report 16 novel LONP1 variants identified in 16 individuals (11 with NDD, 5 with CDH), further expanding the clinical spectrum.
View Article and Find Full Text PDFNature
September 2025
Department of Physics, Harvard University, Cambridge, MA, USA.
Quantum simulations of many-body systems are among the most promising applications of quantum computers. In particular, models based on strongly correlated fermions are central to our understanding of quantum chemistry and materials problems, and can lead to exotic, topological phases of matter. However, owing to the non-local nature of fermions, such models are challenging to simulate with qubit devices.
View Article and Find Full Text PDFGenome Res
September 2025
College of Life Science, Sichuan Agricultural University, Ya'an, 625014, People's Republic of China;
Poultry egg production is shaped by the intertwined action of multiple physiological systems, greatly magnifying the complexity of its underlying genetic regulation. Although multitissue mapping of regulatory variants offers a powerful route to untangle this complexity, comprehensive data sets in ducks remain scarce. Meanwhile, the contributions of peripheral systems beyond neuroendocrine regulation on poultry egg production are still largely unexplored.
View Article and Find Full Text PDFJ Safety Res
September 2025
Center for Injury Research and Policy, Abigail Wexner Research Institute at Nationwide Children's Hospital, Department of Pediatrics, College of Medicine, The Ohio State University, Division of Epidemiology, College of Public Health, USA.
Background: Graduated Driver's Licensing (GDL) policies create an intermediate licensure phase for young novice drivers, and previous studies suggested that they reduce teen motor- vehicle crashes (MVCs). Multiple studies have shown that the effects of GDL laws vary in association with demographic factors and location, motivating estimation of sub-state policy effects. The present study estimates county-level effects of Ohio's 2007 enhanced GDL law on MVCs among 16-17-year-olds.
View Article and Find Full Text PDFBMJ Open
September 2025
Medizinische Fakultät OWL, AG Allgemein- und Familienmedizin, Universität Bielefeld, Bielefeld, Germany
Introduction: Multimorbidity contributes significantly to poor population health outcomes while straining healthcare systems. Although some multimorbid patients experience an accelerated health decline (a decline in well-being or functional status that cannot be attributed to the natural ageing-related health deterioration), others can remain stable for years. Identifying risk factors for accelerated health decline in persons with multimorbidity could help prevent complications and reduce unnecessary interventions.
View Article and Find Full Text PDF