Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Multimorbidity contributes significantly to poor population health outcomes while straining healthcare systems. Although some multimorbid patients experience an accelerated health decline (a decline in well-being or functional status that cannot be attributed to the natural ageing-related health deterioration), others can remain stable for years. Identifying risk factors for accelerated health decline in persons with multimorbidity could help prevent complications and reduce unnecessary interventions. Our review, therefore, aims to map the evidence on the clinical, biographical and healthcare-related factors associated with an accelerated health decline in multimorbid individuals.
Methods And Analysis: We will use the evidence-mapping review methodology. We will perform a systematic comprehensive literature search in Medline via Pubmed, Cochrane Library, EMBASE, Web of Science and Google Scholar using two broad concepts: 'multimorbidity' and 'longitudinal studies'. We will search with MeSH terms (eg, 'Multimorbidity' (Majr), 'Longitudinal Studies' (Majr)) and free text words (eg, multimorbidity, multiple chronic condition*, longitudinal), from inception to date of the final search. All original quantitative studies involving participants in primary care and related healthcare settings will be included. Abstract/titles and full-text screening and data extraction will be performed independently by two or more researchers to minimise selection and reporting bias, with conflicts resolved by consensus. The data will be analysed qualitatively, and topics will be extracted to create evidence clusters. Risk factors will be classified in groups and cross-referenced against the outcomes from respective studies into combinations of exposure-outcome clusters. The resulting evidence clusters will be described narratively and presented as bubble plots. The search, initiated in January 2023, will be updated following this protocol review to reflect the most current evidence; exact dates will be reported in the results manuscript.
Ethics And Dissemination: Due to the nature of the proposed evidence map, ethics approval will not be required. Results from our research will be disseminated through publications in peer-reviewed journals and presentations at local, national and international conferences. OSF REGISTRATION DOI: https://osf.io/q72xa/.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1136/bmjopen-2025-100699 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
High-resolution longitudinal changes in the cortical morphology of youth with family history of bipolar disorder.
Br J Psychiatry
September 2025
Neuroscience Research Australia, Randwick, New South Wales, Australia.
Background: Individuals with a family history of bipolar disorder are at increased risk of developing affective psychopathology. Longitudinal imaging studies in young people with familial risk have been limited, and cortical developmental trajectories in the progression towards illness remain obscure.
Aims: To establish high-resolution longitudinal differences in cortical structure that are associated with risk of bipolar disorder.
Interunit reliability of STATSports APEX global navigation satellite system and accelerometer-derived metrics during shuttle run protocols of varied distances and change of direction frequency.
J Sports Sci
September 2025
School of Health and Sports Sciences, University of Suffolk, Ipswich, UK.
This study assessed the interunit reliability of Global Navigation Satellite System (GNSS) and accelerometer-derived metrics during high-intensity shuttle run protocols. Thirty-three female football players completed three shuttle run protocols (2 × 20 m, 4 × 10 m, and 8 × 5 m). Two STATSports Apex Pro units (18 Hz GPS and 10 Hz Augmented GNSS; 100 Hz accelerometer) recorded accelerometer-derived (fatigue index [FI] and dynamic stress load [DSL]) and GNSS-derived (total distance, acceleration and deceleration counts, maximum speed, speed intensity and total metabolic power) metrics.
View Article and Find Full Text PDFFew-shot learning for highly accelerated 3D time-of-flight MRA reconstruction.
Magn Reson Med
September 2025
Centre for Integrative Neuroimaging, FMRIB Division, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Purpose: To develop a deep learning-based reconstruction method for highly accelerated 3D time-of-flight MRA (TOF-MRA) that achieves high-quality reconstruction with robust generalization using extremely limited acquired raw data, addressing the challenge of time-consuming acquisition of high-resolution, whole-head angiograms.
Methods: A novel few-shot learning-based reconstruction framework is proposed, featuring a 3D variational network specifically designed for 3D TOF-MRA that is pre-trained on simulated complex-valued, multi-coil raw k-space datasets synthesized from diverse open-source magnitude images and fine-tuned using only two single-slab experimentally acquired datasets. The proposed approach was evaluated against existing methods on acquired retrospectively undersampled in vivo k-space data from five healthy volunteers and on prospectively undersampled data from two additional subjects.
Accelerated motion-robust abdominal 3D T1ρ mapping using diamond radial sampling.
Magn Reson Med
September 2025
Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Purpose: To develop and validate a fast, motion-robust, free-breathing abdominal 3D T1ρ mapping method by combining variable-density diamond radial k-space sampling with fast-MAPSS (magnetization-prepared angle-modulated partitioned-k-space spoiled gradient-echo snapshots).
Methods: 3D MAPSS T1ρ imaging was performed at 3T using five spin-lock time (TSL) pairs in phantom scans and three TSL pairs in nine healthy volunteers. Phantom experiments compared Cartesian sampling (reference) with stack-of-stars and diamond radial sampling.
Accelerating patient transitions from hospital to home in the United Kingdom with single-use negative pressure wound therapy: a discharge pathway.
Wounds
August 2025
Solventum, Maplewood, MN, USA.
Background: Initially limited to inpatient use, negative pressure wound therapy (NPWT) is now frequently used in community settings. However, complexities in wound management step-down strategies in the United Kingdom, including regional variations in referral processes, lack of consensus on funding criteria, and limited availability of NPWT units, have led to extended hospital length of stay (LOS) for patients ready for discharge but still needing NPWT. Single-use NPWT (sNPWT) can serve as a bridge between hospital and community NPWT.
View Article and Find Full Text PDF