Determinants and implications of mobile health application acceptability in high-income countries: an assessment.

Drug Discov Today

School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-Ku, Tokyo 142-8501, Japan; Ritsumeikan University, Osaka 567-8570, Japan; Center for Research and Education on Drug Discovery, The Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-08

Published: August 2025


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Article Abstract

Here, we synthesize evidence for the determinants influencing mobile health (mHealth) application acceptability in high-income countries. Based on a synthesis of key studies, we identify that performance expectancy, trust, effort expectancy, social influence, and facilitating conditions significantly shape user acceptance. These factors are further influenced by age, digital literacy, and motivation. Findings show that technical quality alone does not ensure adoption; successful integration requires clinical alignment, institutional trust, and user-centered design. Thus, progress in the use of mHealth applications will depend on collaboration among technologists, healthcare providers, and patients to co‑create solutions that meet both real needs and constraints.

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http://dx.doi.org/10.1016/j.drudis.2025.104460DOI Listing

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