Determinants and implications of mobile health application acceptability in high-income countries: an assessment.

Here, we synthesize evidence for the determinants influencing mobile health (mHealth) application acceptability in high-income countries. Based on a synthesis of key studies, we identify that performance expectancy, trust, effort expectancy, social influence, and facilitating conditions significantly shape user acceptance. These factors are further influenced by age, digital literacy, and motivation.

Effects of Passive Information Dissemination on Human Papillomavirus Vaccination Attitudes and Knowledge Among Pharmacy Visitors: A Cluster Randomized Controlled Trial.

Background: In Japan, human papillomavirus (HPV) vaccination rates remain low, partially owing to safety concerns from media reports. Pharmacies, as accessible healthcare facilities, often serve as sources of health information. However, the impact of passive information provision in pharmacies on public awareness and behavioral intentions has not been completely evaluated.

Mass spectrometry-based methods for biofluid biomarkers for progressive diseases: amyloid peptides and dystrophins.

Purpose: Using two diseases, Alzheimer's disease and muscular dystrophy as examples, in which many resources have been invested, trends in bioanalytical techniques for detection of peptide or protein biomarkers using mass spectrometry are reviewed using Web of Science database. Amyloid beta peptides have been used to detect Alzheimer's disease, and peptides obtained by tryptic digestion of dystrophin have been used to detect muscular dystrophy. Based on the recent interest in peripheral blood analysis, literature review was focused on biofluid analysis.

Entrepreneurial Intention Among Engineering Students: The Moderating Role of Entrepreneurship Education in Japan.

With the growing interest in entrepreneurship, increased attention has been paid to entrepreneurship education. In recent years, attention has been paid to entrepreneurship education in engineering majors. This study examines the impact of attitude, subjective norms, and self-efficacy toward entrepreneurial intention and the moderating role of entrepreneurship education among students at the National Institute of Technology, Tsuruoka College, Japan.

The Co-Evolution of Markets and Regulation in the Japanese Functional Food Industry: Balancing Risk and Benefit.

Amid the global rise in chronic diseases and escalating costs, functional foods have become a preventive solution, offering benefits beyond essential nutrition. However, the regulatory landscape remains complex, requiring a balance between consumer protection and industry innovation. Previous studies seldom examine how markets and regulation evolve, leaving a clear gap that this review addresses.

Leveraging mHealth wearables for managing patients with Alzheimer's disease: a scoping review.

In this scoping review, we examine the role of wearable devices in diagnosing, treating, and monitoring Alzheimer's disease (AD) and mild cognitive impairment (MCI). It identifies various devices, including fitness trackers, smartwatches, electroencephalographic equipment, and sensors, which are used for monitoring physical activity, sleep patterns, and cognitive functions. Our review highlights the potential of these devices for early diagnosis and treatment, improving patient autonomy and quality of life.

Cross-Analysis of mHealth Social Acceptance Among Youth: A Comparative Study Between Japan and China.

Although mobile health (mHealth) technologies have emerged as a revolutionary approach to enhance healthcare delivery, few studies have examined how it is perceived and accepted in different cultures. This study investigated mHealth's social acceptance among young people in Japan and China, with a focus on cultural influences on technology adoption. A comparative analysis approach was adopted, employing an extended unified theory of acceptance and use of the technology model.

Evolving Research and Development Landscape for Rare Diseases: Growing Concerns Over Orphan Drug Lag in Japan.

Patients with rare diseases worldwide face substantial unmet therapeutic needs. In Japan, drug lag-delays in drug approval compared to other countries-has resurfaced as a pressing public health issue. This study analyzes orphan drugs (ODs) approved in the United States (US) from 2005 to 2021, examining OD lag trends, and research and development (R&D) models to streamline OD development in Japan.

Multi-layer platform coordination for open innovation in oligonucleotide therapeutics.

As technology evolves and medical needs diversify, the pharmaceutical industry must accelerate its openness. This study analysed inter-organizational alliances in R&D for the new modality of oligonucleotide therapeutics to explore the requirements for establishing new markets. The results confirmed that the market has developed in stages, employing open innovation for different purposes according to technological progress.

X-206 exhibits broad-spectrum anti-β-coronavirus activity, covering SARS-CoV-2 variants and drug-resistant isolates.

Coronaviruses such as the Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and SARS-CoV-2, causing MERS, SARS, and Coronavirus disease-19, respectively, are highly pathogenic to humans. Notably, several antiviral drugs against SARS-CoV-2, such as nirmatrelvir and remdesivir, have been approved. However, no approved vaccines or antiviral agents are available for other highly pathogenic β-coronaviruses.

Driving Innovation Through Regulatory Design and Corporate Behaviour: A Case Study of Functional Food Industry in Japan.

This study addresses the critical need for innovation in the healthcare sector, particularly in Japan's functional food industry, amid rising chronic diseases and healthcare costs. It explores the complex relationship between regulatory design and corporate behaviour, focusing on how companies' compliance strategies influence their research and development (R&D) investments. A mixed-method approach was used, analysing data from 15 major dietary supplement companies and 74 products under Japan's Foods with Function Claims (FFCs) regulation.

Telemedicine Research Trends in 2001-2022 and Research Cooperation Between China and Other Countries Before and After the COVID-19 Pandemic: Bibliometric Analysis.

Background: Advancements in technology have overcome geographical barriers, making telemedicine, which offers remote emergency services, healthcare, and medication guidance, increasingly popular. COVID-19 restrictions amplified its global importance by bridging distances.

Objective: This study aimed to analyze Chinese and global literature data, present new global telemedicine research trends, and clarify the development potential, collaborations, and deficiencies in China's telemedicine research.

Promoting the social implementation of digital and mobile health: effects of regulation on user and non-user behavior in East Asia.

This study conducted policy and regulation analyses and user acceptance surveys in three East Asian countries with developed telecommunication infrastructure (China, South Korea, and Japan) to determine the most effective way to implement mobile health (mHealth). Regional differences in users' emphasis on the purpose of mHealth, including medical information referral or health management, appear to be influenced by regional regulation, thus making regulation analysis important when considering mHealth penetration strategies. Potential mHealth users have high expectations for medical information and correspondence, which is crucial for the pharmaceutical industry in terms of providing information and retaining patients.

How Social Influence Promotes the Adoption of Mobile Health among Young Adults in China: A Systematic Analysis of Trust, Health Consciousness, and User Experience.

As mobile health (mHealth) offers several advantages in healthcare, researchers are exploring the motivational factors for its adoption. However, few studies have elucidated the complex relationship between social influence and behavioral intentions to adopt mHealth among young adults in China. This study explored the impact of social influence on young adults' behavioral intentions to adopt mHealth, the mediating roles of trust and health consciousness, and the moderating effect of mHealth user experience on the relationship between the predictors.

Increasing orphan drug loss in Japan: Trends and R&D strategy for rare diseases.

Rare disease (RD) patients face significant unmet therapeutic needs worldwide. However, orphan drugs approved in the United States, but not approved or developed in Japan, have increased rapidly with recently increasing US approvals, indicating greater RD drug loss in Japan. US/EU-based startups have become key players in RD drug R&D, significantly contributing to this drug loss trend.

Global biomarker trends in Alzheimer's research: A bibliometric analysis.

Alzheimer's disease (AD) has no effective treatment, although antibody drugs targeting beta-amyloid, mainly aducanumab, have produced useful clinical results. Biomarkers can be used to determine drug regimens effectively and to monitor the effects of drugs. A concept in which biomarkers reflect disease states is emerging.

Strategic trends of pharmaceutical companies: A growth model through regional focus and inter-regional alliances.

Pharmaceutical companies face challenges in business continuity resulting from declining research and development productivity. This study examines the relationship between two strategic pillars: region and therapeutic area, while considering company size. The results indicate that a therapeutic area focus is an effective strategy for small/medium-sized companies, whereas a regional focus is effective for larger companies.

Optimizing the Relationship between Regulation and Innovation in Dietary Supplements: A Case Study of Food with Function Claims in Japan.

Regulation has long been a counterpart of innovation in the health care industry, and recent cases have demonstrated that appropriately designed regulations can both coexist with and promote innovation. This study is the first study to explore how the regulatory environment affected the innovation process during the transition of the regulations for functional foods in Japan by examining quantitatively the impact of the foods with function claims (FFC) system on industry, companies, and products. Based on a dataset of Japanese dietary supplement manufacturing companies (n = 169) and their products (n = 731) in 2019, we found that companies that have newly entered the FFC system are smaller in scale than existing companies (p < 0.

Recent trends in interorganizational deal networks in pharmaceutical and biotechnology industries.

While there have been trends in drug discovery from small molecules to new chemical modalities since the large mergers and acquisitions (M&A) of pharmaceutical companies in the late 2000s, trends in interorganizational deal networks have not been well addressed. We investigated the changing trends in interorganizational deals in the pharmaceutical and biotechnology industries. The results demonstrated that there have been changing trends, including a growing number of spinouts from academia and M&A in the United States and Europe.

A Bibliometric Analysis of Wearable Device Research Trends 2001-2022-A Study on the Reversal of Number of Publications and Research Trends in China and the USA.

In recent years, Wearable Devices have been used in a wide variety of applications and fields, but because they span so many different disciplines, it is difficult to ascertain the intellectual structure of this entire research domain. No review encompasses the whole research domain related to Wearable Devices. In this study, we collected articles on wearable devices from 2001 to 2022 and quantitatively organized them by bibliometric analysis to clarify the intellectual structure of this research domain as a whole.

Determination of Waste Management Workers' Physical and Psychological Load: A Cross-Sectional Study Using Biometric Data.

Waste management workers experience high stress and physical strain in their work environment, but very little empirical evidence supports effective health management practices for waste management workers. Hence, this study investigated the effects of worker characteristics and biometric indices on workers' physical and psychological loads during waste-handling operations. A biometric measurement system was installed in an industrial waste management facility in Japan to understand the actual working conditions of 29 workers in the facility.

Social Acceptance of Mobile Health among Young Adults in Japan: An Extension of the UTAUT Model.

The unprecedented development of information and communication technologies has opened up immense possibilities in the field of health care. Mobile health (mHealth) is gaining increasing attention as an important technology for solving health-related problems. Although a high rate of smartphone usage among young people in Japan has been identified, smartphone usage for health management is not high.

The gap between development and manufacturing in gene therapy: Strategic options for overcoming traps.

Gene therapy has been one of the most promising therapeutic approaches in recent years. This study analyzed a research and development (R&D) system for adeno-associated virus (AAV)-based gene therapies, and confirmed that there was a gap between the development and manufacturing capabilities. Although a start-up company that has no academic or manufacturing facilities can begin the clinical development process, it cannot successfully continue development activities without forming alliances and capital investment or, at a certain stage, without appropriate manufacturing and marketing strategies.

What is the importance of difference in LCM strategy in drug development? - Learnings from Keytruda and Opdivo.

Immune checkpoint inhibitors have changed how cancer is treated. As of February 2022, six immune checkpoint inhibitors had been approved, with Keytruda and Opdivo accounting for the majority of global sales. Here, the impact of the differences in commercial success between Keytruda and Opdivo is reviewed by analyzing inter-organizational deals since their launch in 2014.