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Objective: To investigate the occurrence and causes of neurological dysfunction after interventional embolization for brain arteriovenous malformations (bAVM) in nonfunctional areas.
Methods: A retrospective analysis was performed on the clinical data of 41 patients with bAVM in nonfunctional areas who underwent endovascular interventional embolization in our hospital from March 2020 to February 2025. The modified Rankin scale (mRS) was used to evaluate the occurrence of neurological dysfunction before surgery and 3 days after surgery. An increase in the scale score was considered a new postoperative injury, and the causes were analyzed.
Results: According to the Spetzler-Martin grading, 39 of the 41 patients with bAVM in nonfunctional areas (95.12%) had an mRS score ≤2 points 3 days after surgery, indicating good overall surgical results. Two patients (4.88%) showed an increase in mRS score, suggesting new neurological dysfunction, including 1 case (2.44%) with hemorrhage and death, and 1 case (2.44%) with local cerebral ischemia.
Conclusion: Interventional embolization is a safe and effective treatment for bAVM in nonfunctional areas. Although nonfunctional areas are relatively safe for surgery, there is a certain incidence of postoperative neurological dysfunction. Adopting different treatment strategies, personalized therapy, and avoiding intraoperative complications are the keys to reducing the occurrence of postoperative neurological dysfunction.
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http://dx.doi.org/10.1097/SCS.0000000000011856 | DOI Listing |
Mov Disord Clin Pract
September 2025
Department of Neurology, Danish Dementia Research Centre, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
Background: Early identification of pathological α-synuclein deposition (αSynD) may improve understanding of Lewy body disorder (LBD) progression and enable timely disease-modifying treatments.
Objectives: We investigated αSynD using a seed amplification assay and assessed prodromal LBD symptoms in individuals with idiopathic olfactory dysfunction (iOD).
Methods: In this cross-sectional, case-control study, we included iOD participants and normosmic healthy controls (HC) aged 55 to 75 years without diagnoses of dementia with Lewy bodies, Parkinson's disease (PD), or other major neurological disorders.
CNS Neurosci Ther
September 2025
Affiliated Rehabilitation Hospital, Jiang Xi Medical College, Nanchang University, Nanchang, Jiangxi, China.
Objective: Traumatic brain injury (TBI), a prevalent neurological disorder worldwide, is marked by varying degrees of neurological dysfunction. A key contributor to secondary damage and impediments in the repair process is the unregulated activation of microglia, which triggers neuroinflammation. Emerging evidence highlights the therapeutic potential of transcranial pulsed current stimulation (tPCS) in mitigating neurological deficits.
View Article and Find Full Text PDFImmunopharmacol Immunotoxicol
September 2025
Neuroscience Research Center, Suleyman Demirel University, Isparta, Türkiye.
Background: Microglia are brain resident cells that control neural network maintenance, damage healing, and brain development. Microglia undergo apoptosis, cytokine production, and reactive free radicals of oxygen (ROS) in response to lipopolysaccharide (LPS) stimulation. TRPM2 is activated by LPS-induced oxidative stress, but it is inhibited by carvacrol (CARV) and N-(p-amylcinnamoyl)anthranilic acid (ACA).
View Article and Find Full Text PDFWIREs Mech Dis
September 2025
GIMUNICAH, Faculty of Medicine, Pontificia Universidad Católica de Honduras, San Pedro Sula, Honduras.
The nucleolus, traditionally known for its role in ribosome biogenesis, is now recognized for its broader functions, including cellular stress adaptation and its involvement in various pathological processes, such as ribosomal alterations, viral infections, autoimmune disorders, and age-related diseases. Disruptions in nucleolar function can impair protein synthesis, cellular homeostasis, and immune responses, leading to multisystem disorders and increased susceptibility to neoplasms. This review classifies nucleolus-associated diseases into seven categories: deficiencies in protein synthesis, ribosomal and non-ribosomal alterations, cancer and nucleolar alterations, diseases related to aging and cellular stress, autoimmune diseases, and viral diseases.
View Article and Find Full Text PDFACS Chem Neurosci
September 2025
School of Life Science and Technology, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing 210096, China.
Glial cells play an indispensable role in the nervous system, providing structural support to neurons and regulating their function and development. Glia support neural network formation and plasticity in axon guidance, synaptic pruning, and neurogenesis. Of note, studies have shown that glial cell dysfunction is closely related to the occurrence of neurological diseases.
View Article and Find Full Text PDF