Morphine inhibits the TRPM2 signaling pathways in microglia cells, reducing the increases in oxidative stress, cytokines, and cell death caused by lipopolysaccharide.

Background: Microglia are brain resident cells that control neural network maintenance, damage healing, and brain development. Microglia undergo apoptosis, cytokine production, and reactive free radicals of oxygen (ROS) in response to lipopolysaccharide (LPS) stimulation. TRPM2 is activated by LPS-induced oxidative stress, but it is inhibited by carvacrol (CARV) and N-(p-amylcinnamoyl)anthranilic acid (ACA).

Effects of Progressive Muscle Relaxation on Pain and Sleep: Randomized Controlled Study.

Purpose: This study aimed to evaluate the effectiveness of Progressive Muscle Relaxation (PMR) on postoperative pain level and sleep quality in patients undergoing open heart surgery.

Design: A single center, two-group, single-blind randomized controlled trial.

Methods: This study comprised 60 patients who were admitted to the cardiovascular surgery department and undergoing open heart surgery between January 2023 and April 2024.

The effect of chatbot-supported instruction on nursing students' history-taking questioning skills and stress level: A randomized controlled study.

Background: Comprehensive history-taking is crucial for patient assessment, prioritisation of care, and planning of care. While direct instruction methods effectively explain history-taking processes and components, they provide insufficient opportunities for practice, necessitating the implementation of supplementary teaching strategies.

Objective: This study aimed to examine the effects of AI chatbot-supported history-taking training on nursing students' questioning skills and clinical stress levels.

Identification of serum biomarkers associated with microvascular functions in a long-term high-fat diet-induced obesity rat model.

Serum biomarkers are crucial for identifying complications of obesity. This study evaluated serum levels of leptin, vascular endothelial growth factor (VEGF), myeloperoxidase (MPO), C-reactive protein (CRP), oxidized low-density lipoprotein (OXLDL), low-density lipoprotein (LDL), and other biochemical parameters in a rat model of high-fat diet (HFD)-induced obesity to investigate potential relationships between these biomarkers and microvascular function. Rats in the HFD group were fed a high-fat diet for 23 weeks, whereas control rats received a standard diet.

SHH Pathway Inhibition and Astrocyte Co-culture Induce Distinct Responses in Glioblastoma and Cancer Stem Cells.

Glioblastoma (GBM) represents an extremely aggressive brain malignancy with limited treatment options, difficult prognosis and a highly heterogeneous cellular architecture, including a subpopulation of cancer stem-like cells (CSCs). These CSCs frequently rely on developmental signaling pathways such as Sonic Hedgehog (SHH), which are typically dormant in adult tissue but reactivated in tumors. This study aimed to investigate how SHH pathway inhibition affects both bulk GBM cells (GBMCs) and CD133 + GBM cells (GBM CSCs), with particular emphasis on the influence of astrocyte co-culture, which more closely mimics the brain tumor microenvironment.

Evaluation of "The Interprofessional Education Academy".

This study evaluated the impact of the "1st Interprofessional Education Academy" on the interprofessional identity and attitudes of healthcare students in Turkey. This was a 4 day national training program for 24 health professionals aimed to increase effective collaboration and communication skills, support the development of professional identity, and strengthen the implementation of IPE in Turkey. Twenty-four female participants (mean age: 22.

The role of different rest periods on post-activation performance enhancement in plyometric preload.

Background: The optimal combination of factors such as rest duration, type of activity, and individual variability for maximizing post-activation performance enhancement (PAPE) following plyometric conditioning activity (plyometric CA) remains a subject of debate. To investigate the effects of different rest periods (4, 8, and 12 min) on performance following plyometric CA, this randomized controlled study was conducted.

Methods: Twenty physically active men were included in this study (mean ± SD: age 20.

Neoadjuvant response stratification based on complete, partial, and no response in HR-positive/HER2-positive breast cancer.

Background: This study aimed to evaluate the prognostic relevance of stratified pathological response -complete response (CR), partial response (PR), and no response (NR)- to neoadjuvant chemotherapy (NAC) in patients with hormone receptor-positive and HER2-positive (HR + /HER2 +) breast cancer.

Methods: A total of 8277 HR + /HER2 + breast cancer patients treated with NAC between 2010 and 2021 were retrospectively identified from the SEER database. Patients were categorized into CR, PR, and NR groups.

Healthy lifestyle beliefs, nutritional behaviors, and physical activity of adolescents: A mediation analysis.

Although the Covid-19 pandemic has ended, its negative impacts on adolescents' physical activity levels, nutritional behaviors, and healthy lifestyle beliefs persist. This study aimed to examine whether physical activity (PAS) mediates the relationship between healthy lifestyle beliefs (HLB) and nutritional behaviors (NBS) among adolescents. This study was a quantitative study, with a cross sectional survey design.

Percutaneous renal biopsy adverse event rates: Coaxial or non-coaxial technique.

The purpose of this study was to compare the coaxial and non-coaxial techniques in terms of adverse events (AEs) resulting from the percutaneous renal biopsy. A secondary aim was to determine the potential effect of the sclerosed glomeruli on AEs. Patients who underwent ultrasonography-guided percutaneous renal biopsy in our interventional radiology clinic between January 2013 and December 2021 were scanned retrospectively.

Integrated spectroscopic and morphological analyses reveal cellular shifts in gene-silenced melanoma CSCs.

Intratumoral heterogeneity remains a major barrier to durable cancer therapies, largely driven by the persistence of cancer stem cells (CSCs). In this study, we employed an integrated, multi-scale approach to investigate how melanoma CSCs respond to siRNA-mediated silencing of three key regulatory genes: KLF4, SHH, and HIF1α. Using a combination of morphological, molecular, spectroscopic, and elemental analyses, we explored structural and biochemical consequences of gene knockdown.

Effect of topical nitroglycerin on neoangiogenesis and pedicle-independent viability in a rat dorsal skin flap model.

Interpolated flaps are frequently used in reconstructive surgery when free tissue transfer is not feasible, but they require staged procedures due to pedicle dependence. Flap autonomization, the process by which transferred tissue develops new vascular connections and survives independently of its pedicle, is essential before division. Although methods such as delay techniques, hyperbaric oxygen (HBO), vascular endothelial growth factor (VEGF), and stem cell therapies have been tested to enhance angiogenesis, the effect of topical nitroglycerin (NTG), a nitric oxide (NO) donor with vasodilatory, anti-inflammatory, and angiogenic properties, has not been investigated.

The Effect of Transition Model-Based Discharge Training for Mothers of Late Preterm Infants (TRAMPRE): A Randomized Controlled Study.

The aim of the study was to evaluate the effect of Transition Model-Based Discharge Training for Mothers of Preterm Infants (TRAMPRE) on (1) Kenner's three components of the transition to home; (2) post-partum depression; (3) unplanned hospital/family health center visits; and (4) post-discharge complications. Our study was conducted with 133 mothers who received services in the NICU of a hospital providing tertiary health care in Türkiye. The content of the intervention protocol consists of "Discharge Training for Mothers on Infant Care," the "Preterm Infant Care Guide," and "Telephone Follow-up and Counseling.

Predictive value of machine learning-based T2-weighted MRI radiomics in the diagnosis of polycystic ovary syndrome.

Objective: This study aims to explore the predictive performance of machine learning-based radiomic features extracted from T2-weighted magnetic resonance imaging (MRI) in differentiating between women with polycystic ovary syndrome (PCOS) and healthy counterparts.

Methods: The study included patients diagnosed with PCOS who had undergone pelvic MRI in the endocrine department between 2014 and 2022, along with an age-matched control group. The ovaries were manually segmented from T2-weighted images using the 3D Slicer software.

Design of multi-layer electrospun poly(ε-caprolactone)/chitosan nanofiber scaffolds loaded with tigecycline for controlled drug release and antibacterial wound healing.

In this study, a novel multi-layer scaffold composed of poly(ε-caprolactone) (PCL) and chitosan (CS) was designed and fabricated via electrospinning, with tigecycline (Tig) incorporated as an antimicrobial agent in the middle layer. This nanofibrous multi-layer structure consisted of hydrophobic PCL outer and inner layers and a hydrophilic PCL-CS-Tig middle layer, designed to mimic the structural functionality of the native extracellular matrix. SEM analysis revealed that the fabricated nanofibrous layers were uniform, beadless fibers with diameters ranging from 689 ± 186 nm for the pure PCL layers to 125 ± 19 nm in the PCL-CS matrix loaded with Tig (single-layer), and further increased to 298 ± 98 nm in the multi-layer dressing.

The effect of mukbang watching on eating attitudes mediated uncontrolled eating, cognitive restriction, and emotional eating.

Purpose: Mukbang, defined as an audio-visual broadcast in which broadcasters commonly eat large portions of tasty food, is a sociocultural trend that can be associated with eating disorders. This study was conducted to evaluate the effect of watching mukbang on eating attitudes through uncontrolled eating, cognitive restriction, and emotional eating.

Methods: Questionnaire was included the mukbang addiction scale to assess problematic mukbang viewing, the eating attitude test (EAT-26) to assess eating attitudes, and the three-factor eating scale to assess eating behaviours.

From hospital to home: Mothers' experiences of postpartum and post-discharge care for preterm infants- A phenomenological study based on the transition model.

Purpose: The aim of the study is to understand and describe the experiences of mothers with late preterm infants in infant care after birth and discharge based on the "Transition Model".

Design And Methods: This study used a descriptive phenomenological design. The research data were collected through a semi-structured interview form via home visit by face-to-face interview method.

The Impact of Fissure-Adjacent Localization on Rupture Risk in Pulmonary Hydatid Disease.

Background Pulmonary hydatid cyst (PHC) rupture is a serious complication that can increase surgical difficulty and postoperative morbidity. Identifying preoperative predictors of rupture is essential for patient risk stratification and optimal surgical timing. This study aimed to evaluate clinical, radiological, and laboratory factors associated with cyst rupture, with a particular focus on the anatomical relationship with lung fissures.

Mechanism of actions of probiotics on type 2 diabetes: Development and complications.

Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disorder described by chronic hyperglycemia, insulin resistance, as well as low-grade inflammation. Recent research highlights the vital role of the gut microbiota in the pathogenesis and progression of T2DM. Dysbiosis can impair intestinal barrier integrity, promote systemic inflammation, and contribute to insulin resistance and glucose metabolism dysfunction.

Exploring the anticancer potential of novel benzimidazolium Salts: Synthesis, biological evaluation, DFT perspective, and docking simulation for inhibition of VEGFR2.

In this study, benzimidazolium salts were designed and prepared in two steps. Synthesized compounds 3a and 3b were evaluated on human cancer cell lines (A549, HepG2, and MCF-7). IC values and selectivity indices were calculated.

The effect of reflexology on blood pressure and heart rate in cardiovascular patients: a meta-analysis study.

Objective: The aim of the study was to conduct a meta-analysis of studies on the effect of reflexology on blood pressure and heart rate in patients with cardiovascular disease.

Method: The study collected data from PubMed, ScienceDirect, MEDLINE, Web of Science, Google Scholar, and Cochrane Library databases. The study had randomized-controlled, non-randomized-controlled, and quasi-experimental designs.

Classification success of salivary interleukin-1β in periodontitis grading with artificial intelligence models: a cross-sectional observational study.

Objectives: Finding certain biomarkers and threshold values of periodontitis and incorporating them into classifications can further highlight its impact on systemic health. This cross-sectional observational study aims to evaluate the efficacy of some biomarkers in grading periodontitis using artificial intelligence (AI) models.

Methodology: AI models were developed to automatically classify periodontal status (N=240) and grades in periodontitis patients (n=120) using Python based on sociodemographic, anthropometric, clinical, radiological, and biochemical attributes.

Corrosive substance ingestion in children: clinical features, management and outcomes in a tertiary care setting.

Objective: Corrosive substance ingestion remains a significant public health issue in children, often associated with insufficient preventive practices. This study aimed to evaluate the clinical presentation, endoscopic findings, clinical course, and treatment outcomes of pediatric patients admitted to our hospital after corrosive ingestion.

Materials And Methods: A total of 311 children who presented to our center with caustic ingestion between January 2007 and December 2024 were included in the study.