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G. Mirone, S. Perna, A. Shukla, G. Marfe, "Involvement of Notch-1 in Resistance to Regorafenib in Colon Cancer Cells," Journal of Cellular Physiology 231, no. 5 (2015): 1097-1105, https://doi.org/10.1002/jcp.25206. The above article, published online on 30 September 2015 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Robert Heath; and Wiley Periodicals LLC. The retraction has been agreed due to concerns raised by the third party, which revealed inappropriate figure duplications in Figure 5B and Figure 7D, by different groups of authors in different articles. In addition, there are inconsistencies in Figure 2B. The corresponding author has responded in accordance with the concerns and provided the original western blots for Figure 5B and explanation for Figure 2B. However, data issues were found in the last authors' other articles and the Editor-in-Chief now has lost confidence in the integrity and reliability of the full body of data presented in the article and consider the conclusions of this manuscript substantially compromised. The authors were informed of the retraction.
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http://dx.doi.org/10.1002/jcp.70082 | DOI Listing |
J Cell Physiol
August 2025
G. Mirone, S. Perna, A.
View Article and Find Full Text PDFAnn Surg Oncol
September 2025
Department of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Background: Bladder cancer poses a significant global health challenge, with a complex pathogenesis that includes a subpopulation of cancer stem cells (CSCs) contributing to therapy resistance and tumor recurrence. Identifying and understanding the role of CSC markers are crucial for developing targeted therapies and improving prognosis.
Objective: This systematic review and meta-analysis aimed to assess the clinicopathological significance and prognostic value of CSC markers in patients with bladder cancer.
J Cell Mol Med
March 2025
Faculty of Medicine, Department of Medical Biochemistry, Düzce University, Düzce, Turkey.
The development of resistance to chemotherapy in the case of aggressive glioblastoma multiforme (GBM) presents a significant treatment challenge. Dysregulation of the Notch signalling pathway promotes tumour proliferation in GBM cells. This study was that targeting the Notch signalling pathway could be a potential therapeutic approach for GBM.
View Article and Find Full Text PDFInt J Pharm
February 2025
Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty, The Nilgiris, Tamil Nadu, India. Electronic address:
Triple-negative breast cancer (TNBC) is a subtype known for its aggressive nature, high rates of recurrence, and treatment resistance, largely attributed to the presence of breast cancer stem cells (BCSCs). Traditional therapies often struggle to eliminate BCSCs, which contributes to tumor recurrence. One promising strategy for addressing this challenge is targeting the Notch signaling pathway, which plays a critical role in the self-renewal and maintenance of BCSCs.
View Article and Find Full Text PDFCell Biol Toxicol
December 2024
Department of General Surgery, First Medical Center of Chinese, PLA General Hospital, Haidian District, No.28 Fuxing Road, Beijing, 100853, China.
Accumulating evidences have indicated that cancer stem cells (CSCs) can initiate tumor progression and cause recurrence after therapy. However, specific markers of gastric CSCs (GCSCs) from different origins have not been comprehensively revealed. Here, we further detected whether cell populations labelled with CD44 and Lgr5, well-recognized stem markers for gastric cancer (GC), can better emphasize cancer initiation, therapeutic resistance and recurrence.
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