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This three-wave longitudinal study used a time course approach to explore the RSA change trajectory during stress. It examined the mediating role of dynamic vagal regulation in the link between childhood abuse and neglect and psychopathological symptoms among adolescents. Physiological and questionnaire data were collected from 151 Chinese adolescents (74 females; M = 12.93, SD = 0.83) between November 2021 and May 2024. Results revealed a quadratic RSA change trajectory during a speech task (first decreased and then increased), and childhood abuse (rather than childhood neglect) was associated with increased risks of internalizing and externalizing symptoms via dynamic vagal dysregulation. These findings suggest that dynamic vagal regulation could serve as a potential mechanism linking childhood abuse with adolescent psychopathological symptoms.
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http://dx.doi.org/10.1111/cdev.70027 | DOI Listing |
Front Immunol
September 2025
Department of Pharmacy, Shenzhen Longhua District Central Hospital, Shenzhen, China.
The immune interactions within the gut-brain axis represent a critical etiological factor in psychiatric disorders. The gut microbiota and their metabolites serve as biological mediators that regulate neuroimmune activation and suppression in the central nervous system (CNS). During intestinal immune activation, pro-inflammatory cytokines (, IL-6, TNF-α) propagate to the CNS compromised blood-brain barrier (BBB) integrity or vagal afferent fibers, disrupting neurotransmitter metabolism and inducing microglial hyperactivation, thereby exacerbating neuroinflammation.
View Article and Find Full Text PDFFront Neurol
August 2025
School of Physical Education and Sport, Ningxia Normal University, Guyuan, China.
Background: Sleep deprivation is prevalent in high-pressure environments and among shift workers, and may contribute to autonomic nervous system (ANS) dysregulation, contributing to cardiovascular diseases, mood disorders, and cognitive impairment. Heart rate variability (HRV), an important indicator of ANS function, reflects fluctuations in sympathetic and parasympathetic activity and is commonly used to assess the autonomic effects of sleep deprivation. However, existing studies exhibit considerable heterogeneity due to inconsistencies in HRV measurement methods, variations in deprivation duration, and inadequate control of confounding factors.
View Article and Find Full Text PDFJ Cardiol
August 2025
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Advanced Cardiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address:
The cardiopulmonary system is not only a pump-respirator network but also a sophisticated sensor-effector circuit. Recent findings have highlighted how mechanical and inflammatory stress in the heart and lungs is transmitted via afferent nerves-including vagal, glossopharyngeal, and spinal fibers-to the brainstem and higher autonomic centers. These afferent signals trigger adaptive or maladaptive efferent responses via the sympathetic nervous system, which in turn modulate immune cell dynamics in the bone marrow and peripheral organs.
View Article and Find Full Text PDFWorld J Diabetes
August 2025
College of Acupuncture, Massage and Rehabilitation, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China.
Background: Diabetic gastroparesis (DGP) disrupts gastric motility. Electroacupuncture (EA) at Zusanli (ST36) may alleviate DGP symptoms neural pathways.
Aim: To investigate how EA current intensities at ST36 regulate neural pathways and improve gastric motility in DGP models.
Child Dev
August 2025
Shaanxi Key Laboratory of Behavior and Cognitive Neuroscience, Shaanxi Key Research Center for Children Mental and Behavior Health, School of Psychology, Shaanxi Normal University, Xi'an, China.
This three-wave longitudinal study used a time course approach to explore the RSA change trajectory during stress. It examined the mediating role of dynamic vagal regulation in the link between childhood abuse and neglect and psychopathological symptoms among adolescents. Physiological and questionnaire data were collected from 151 Chinese adolescents (74 females; M = 12.
View Article and Find Full Text PDF