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Gastrointestinal tuberculosis (GI TB) is an uncommon sequela of extrapulmonary TB, occurring in 1%-3% of TB cases worldwide. In the United States, many cases are seen in migrant populations or in immunocompromised individuals. The classic presentation of GI TB is nonspecific abdominal pain, and is not typically associated with significant, life-threatening bleeding. We present a case of GI TB complicated by severe lower GI bleed requiring vasopressor support in a newly emigrated patient with previously undiagnosed HIV/AIDS.
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http://dx.doi.org/10.14309/crj.0000000000001808 | DOI Listing |
J Drug Target
September 2025
School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, P. R. China.
Tuberculosis (TB), caused by (M. tb), represents a significant challenge to global health. The management of the disease requires an extended course of antibiotic therapy, spanning a duration of 6 to 9 months.
View Article and Find Full Text PDFAnal Biochem
August 2025
Pharmaceutical Analysis Research Center, Pharmaceutical Sciences Institute, Tabriz University of Medical Sciences, Tabriz, Iran; Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Carbamazepine is a widely prescribed antiepileptic drug with a narrow therapeutic index, necessitating precise monitoring to avoid toxicity and ensure therapeutic efficacy. This study presents a fluorescence-based nanosensor using boron nitride quantum dots (BNQDs) for the rapid and sensitive detection of carbamazepine in exhaled breath condensate (EBC). BNQDs were prepared via a simple hydrothermal technique and characterized using transmission electron microscopy, dynamic light scattering, energy-dispersive X-ray, and attenuated total reflectance-Fourier transform infrared techniques.
View Article and Find Full Text PDFFront Cell Infect Microbiol
August 2025
Department of Pathogen Biology, College of Basic Medical Sciences, Jilin University, Changchun, China.
The gut microbiota constitutes a vital ecosystem within the human body playing a pivotal role in immune regulation and metabolic homeostasis. Emerging research underscores a sophisticated interplay between the gut and lungs, termed the "gut-lung axis." Gut microbes exert influence over pulmonary immunity and metabolism via immune mediators (e.
View Article and Find Full Text PDFInt J Surg Case Rep
August 2025
Kathmandu University School of Medical Sciences, Dhulikhel, Nepal.
Introduction: Rectal tuberculosis (TB) is one of the rare presentations of gastrointestinal tuberculosis that often mimics malignancy or inflammatory bowel disease (IBD), presenting as fistulas, ulcers, and chronic pain. Rectal TB is very rare in immunocompetent patients. The mainstay of diagnosis is colonoscopy-guided biopsy.
View Article and Find Full Text PDFRom J Morphol Embryol
August 2025
Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania;
Background∕Objectives: Malakoplakia is an uncommon clinicopathological entity defined by the accumulation of dysfunctional macrophages containing undigested bacterial remnants and pathognomonic Michaelis-Gutmann bodies. Although it most frequently involves the gastrointestinal tract, particularly the colon, rectum, and rectosigmoid junction, appendiceal involvement remains rare. This case represents only the fourth reported occurrence of appendiceal malakoplakia in a young, immunocompetent adult without notable comorbidities, underscoring its exceptional clinical presentation.
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