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What Is Already Known About This Topic?: Chronic diseases and multimorbidity impose substantial burdens on healthcare systems globally, particularly in aging populations, resulting in elevated healthcare utilization rates and increased expenditures.
What Is Added By This Report?: This study validates previous research findings using an extensive administrative database from a major city in South China. Additionally, it provides comprehensive estimates of annual hospitalization expenditures per patient associated with chronic diseases and multimorbidity patterns among older adults, elucidating the economic burden and cost variations across specific diseases and multimorbidity combinations. Cancer, cerebrovascular disease (CVD), and heart disease - whether occurring individually or in conjunction with other chronic conditions, particularly within complex multimorbidity patterns - were associated with substantial annual hospitalization expenditures and significant healthcare resource utilization.
What Are The Implications For Public Health Practice?: Disease burden studies provide critical evidence for prioritizing public health policies and targeted interventions. Policymakers should implement comprehensive prevention strategies, evidence-based interventions, appropriate reimbursement policies, and integrated management approaches to control disease progression and reduce healthcare expenditures.
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http://dx.doi.org/10.46234/ccdcw2025.175 | DOI Listing |
PLoS One
September 2025
School of Public Health, Changzhi Medical College, Changzhi, China.
Background: In China, the prevalence of chronic diseases is increasing, especially in rural areas, affecting younger populations and associating with multimorbidity. However, in resources-limited rural areas, there is a lack of primary data to the prevalence and patterns of multimorbidity in young populations. This study aims to analysis the differences in multimorbidity prevalence and patterns across different age groups and genders among adults in rural Shanxi Province.
View Article and Find Full Text PDFJ Proteome Res
September 2025
Department of Gastroenterology and Hepatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Colorectal cancer (CRC) is a major global health challenge due to its high incidence, mortality, and low rate of early detection. Early diagnosis, targeting precancerous lesions (advanced adenomas) and early stage CRC (Tis and T1), is critical for improving patient survival. Given the limitations of current detection methods for advanced adenomas, developing high-performance early diagnostic strategies is essential for effective prevention.
View Article and Find Full Text PDFNat Sci Sleep
September 2025
Department of Geriatrics, Tianjin Medical University General Hospital; Tianjin Key Laboratory of Elderly Health; Tianjin Geriatrics Institute, Tianjin, People's Republic of China.
Background: Sleep and frailty are established influencing factors for cardiometabolic diseases (CMDs). However, their joint effects on cardiometabolic multimorbidity (CMM) in older adults remain poorly understood. This study aimed to assess the joint effect of sleep health and frailty on CMD prevalence and severity, with an emphasis on subgroup-specific health risk profiles.
View Article and Find Full Text PDFZhonghua Jie He He Hu Xi Za Zhi
September 2025
National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, China-Japan
Interstitial lung disease (ILD) is a group of heterogeneous non-tumor and non-infectious lung diseases with basic lesions of alveolar unit inflammation and interstitial fibrosis. There are hundreds of kinds of ILD. The study of ILD subtypes in China found that the most common disease was idiopathic pulmonary fibrosis (IPF, 26.
View Article and Find Full Text PDFJ Control Release
September 2025
Department of Ultrasound, China-Japan Friendship Hospital, Beijing 100029, China; National Center for Respiratory Medicine; State Key Laboratory of Respiratory Health and Multimorbidity; National Clinical Research Center for Respiratory Diseases; Institute of Respiratory Medicine, Chinese Academy of
Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid malignancy and currently lacks effective treatment options. While anti-PD1 therapy has shown remarkable clinical results in some cases, only a subset of ATC patients responds to it. Eganelisib (IPI549), a highly selective PI3Kγ inhibitor, can alleviate the tumor immunosuppressive state by reducing the proportion of M2-like tumor associated macrophages, partially overcoming patient resistance to anti-PD1 therapy and synergizing with its efficacy.
View Article and Find Full Text PDF