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Distributed Collaborative Machine Learning (DCML) offers a promising alternative to address privacy concerns in centralized machine learning. Split learning (SL) and Federated Learning (FL) are two effective learning approaches within DCML. Recently, there has been growing interest in Split Federated Learning (SFL), which combines elements of both FL and SL. This research provides a comprehensive study, analysis, and presentation of the impact of data poisoning attacks on Split Federated Learning (SFL). We propose three attack strategies: untargeted attacks, targeted attacks, and distance-based attacks. All these strategies aim to degrade the performance of the DCML classifier. We evaluate the proposed attack strategies using two case studies: Electrocardiogram Signal Classification and Automatic Handwritten Digit Recognition (MNIST dataset). We conducted a series of attack experiments, varying the percentage of malicious clients and the model split layer between the clients and the server. A comprehensive analysis of the attack strategies reveals that distance-based and untargeted poisoning attacks have a greater impact on evading classifier outcomes compared to targeted attacks in SFL.
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http://dx.doi.org/10.1038/s41598-025-15993-8 | DOI Listing |
Neural Netw
September 2025
College of Information Science, North China University of Technology, Beijing, China. Electronic address:
Personalized Federated Learning (pFL) has received extensive attentions, due to its ability to effectively process non-IID data distributed among different clients. However, most of the existing pFL methods focus on the collaboration between global and local models to enrich the personalization process, but ignoring a lot of valuable historical information, which represents the unique learning trajectory of each client. In this paper, we propose a pFL method called FedLFH, which introduces a tracking variable that allows each client to preserve historical information to facilitate personalization.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Department of Information Systems and Cybersecurity, The University of Texas at San Antonio, 1 UTSA Circle, San Antonio, TX, 78249, United States, 1 (210) 458-6300.
Background: Adverse drug reactions (ADR) present significant challenges in health care, where early prevention is vital for effective treatment and patient safety. Traditional supervised learning methods struggle to address heterogeneous health care data due to their unstructured nature, regulatory constraints, and restricted access to sensitive personal identifiable information.
Objective: This review aims to explore the potential of federated learning (FL) combined with natural language processing and large language models (LLMs) to enhance ADR prediction.
RSC Med Chem
August 2025
Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Suez Canal University 4.5 Km the Ring Road Ismailia 41522 Egypt.
Protein kinases are central regulators of cell signaling and play pivotal roles in a wide array of diseases, most notably cancer and autoimmune disorders. The clinical success of kinase inhibitors-such as imatinib and osimertinib-has firmly established kinases as valuable drug targets. However, the development of selective, potent inhibitors remains challenging due to the conserved nature of the ATP-binding site, off-target effects, resistance mutations, and patient-specific variability.
View Article and Find Full Text PDFStat Biosci
August 2024
Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.
Large-scale genomics data combined with Electronic Health Records (EHRs) illuminate the path towards personalized disease management and enhanced medical interventions. However, the absence of "gold standard" disease labels makes the development of machine learning models a challenging task. Additionally, imbalances in demographic representation within datasets compromise the development of unbiased healthcare solutions.
View Article and Find Full Text PDFIEEE J Biomed Health Inform
September 2025
Early diagnosis of Parkinson's disease (PD) is crucial for timely treatment and disease management. Recent studies link PD to impaired facial muscle control, manifesting as "masked face" symptoms, offering a novel diagnostic approach through facial expression analysis. However, data privacy concerns and legal restrictions have resulted in significant "data silos", hindering data sharing and limiting the accuracy and generalizability of existing diagnostic models due to small, localized datasets.
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