Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Aims: The study aims to assess the gut microbiota function and the status of bidirectional relationship of gut with other body organs in ulcerative colitis (UC).
Methods And Results: The proteomic analysis of fecal samples revealed the presence of 2072 microbial proteins and 243 human proteins. Microbial proteins for pentose phosphate pathway (PPP) increased significantly in UC samples; whereas, decrease in proteins related to energy metabolism, transmembrane transporters and membrane proteins, and protein folding was noted. Interestingly, expression of proteins related to iron metabolism and oxidative stress indicates an oxidative gut environment that favors the growth of pathogenic microbes, enteric infections, and intestinal damage. Over-expression of host proteins such as neutrophil defensin 3, lactotransferrin, neutrophil elastase, azurocidin, protein S100-A8, protein S100-A9, and cathepsin G further indicate inflammation, and microbial infection in UC gut. The microbial (Omp)-host (TLR4) protein interaction analysis by molecular docking suggests significant implications in immune modulation. Further, gas chromatography-mass spectrometry investigation revealed altered concentration of microbial short chain fatty acids.
Conclusion: The study revealed vital clues about the gut-organ homeostasis in UC that contribute to the host physiology, disease pathogenesis and 'gut-organ axis' fragmentation.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jambio/lxaf207 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phosvitin Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice via Gut Microbiota Modulation.
J Agric Food Chem
September 2025
College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China.
Dietary proteins have been demonstrated to alleviate ulcerative colitis. Phosvitin (PSV), a highly phosphorylated protein, possesses biological functions such as anti-inflammatory and antioxidant activities. This study aimed to investigate the preventive effects of PSV on dextran sulfate sodium (DSS)-induced colitis in mice and its underlying mechanisms.
View Article and Find Full Text PDFJanus Kinase Inhibitors as A Breakthrough Treatment for Refractory Dissecting Cellulitis of the Scalp.
Eur J Case Rep Intern Med
August 2025
Dermatology Department, Ain Shams University Hospital, Cairo, Egypt.
Background: Dissecting cellulitis of the scalp (DCS) is a rare, chronic neutrophilic dermatosis that is often refractory to conventional therapies.
Case Report: We present a 29-year-old male with treatment-resistant DCS who achieved rapid and sustained remission following off-label use of tofacitinib, a Janus kinase (JAK) inhibitor. Previous therapies, including antibiotics, corticosteroids, and isotretinoin, had failed.
Plant-Derived Exosome-Like Nanovesicles: A Novel Strategy for Targeted Oral Therapy in Ulcerative Colitis.
Int J Nanomedicine
September 2025
The First Hospital of Hunan University of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, Hunan, People's Republic of China.
Ulcerative colitis (UC) is a chronic inflammatory bowel disease, the incidence of which continues to rise globally, and existing therapeutic options are limited by low drug bioavailability and systemic side effects. In this study, we systematically investigated the challenges of the special gastrointestinal environment of UC patients for oral drug delivery, such as extreme pH, degradation by digestive enzymes, metabolism of intestinal flora and obstruction of the intestinal mucosal barrier, and summarized the potential of plant-derived Exosome-like Nanovesicles (PELNs) as a novel delivery system. PELNs are produced by plant cells and mainly consist of proteins, RNA, lipids and plant active molecules.
View Article and Find Full Text PDFPioneering the IBD specialist nurse role in China: a shared decision-making model for clinical practice innovation.
Front Med (Lausanne)
August 2025
Department of Nursing, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Background: Inflammatory bowel disease (IBD) is a chronic condition characterized by the need for highly individualized treatment plans, requiring patients to make numerous complex medical decisions. Shared decision-making (SDM) has proven effective in improving treatment outcomes, patient satisfaction, and adherence in IBD management; however, its clinical implementation remains challenging. In China, formal SDM nurse roles have not yet been established.
View Article and Find Full Text PDFBranched-Chain Amino Acids Exacerbate Colitis Progression by Lowering Colonic Fumarate Levels.
Inflamm Bowel Dis
September 2025
Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
Background: Ulcerative colitis (UC) is a gastrointestinal inflammatory condition with an unclear etiology. Recent findings suggest that metabolites play a pivotal role in promoting intestinal health. We have previously observed a significant enrichment in colonic branched-chain amino acids (BCAAs) in resistant mice to colitis suggesting the potential role of these metabolites in UC development.
View Article and Find Full Text PDF