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This study presents an AI-driven generative design framework for creating lightweight, manufacturable mechanical structures. It integrates topology optimization with deep reinforcement learning, specifically the Proximal Policy Optimization (PPO) algorithm, to learn optimal material layouts within a defined design space. The model adheres to strict engineering constraints, including Von Mises stress (≤ 300 MPa) and displacement (≤ 0.5 mm), ensuring structural reliability. Physics-informed learning is enabled through Finite Element Analysis (FEA), enhancing the model's decision-making during training. To improve manufacturability, the framework applies Signed Distance Field (SDF) smoothing and generates STL files suitable for direct 3D printing. Tested on the Topology Optimization Dataset (ToD), the method outperforms conventional approaches like SIMP and level-set techniques, achieving up to 40 % weight reduction while maintaining compliance. A practical case study involving a lightweight wheel hub further validates its real-world applicability. Comprehensive evaluations, including ablation studies and inference-time analysis, demonstrate the method's adaptability, constraint satisfaction, and rapid design-to-prototype transition across engineering domains. Methodology summary includes:•AI-based generative design with PPO under mechanical constraints.•Physics-informed training with FEA and SDF-based STL output.•Evaluated on ToD and validated through a wheel hub case study.
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http://dx.doi.org/10.1016/j.mex.2025.103539 | DOI Listing |
Inorg Chem
September 2025
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130021, P. R. China.
The CO cycloaddition route is an effective way to achieve efficient conversion and utilization of CO. Zeolites with diverse topologies and tunable acidic sites can efficiently promote the cycloaddition reaction of CO with epoxides. The exchangeable cations in zeolites have a great influence on the performance of the CO cycloaddition, but there are few studies on it.
View Article and Find Full Text PDFSci Adv
September 2025
Applied Mechanics Laboratory, Department of Engineering Mechanics, Tsinghua University, Beijing 100084, P.R. China.
Bioinspired network designs are widely exploited in biointegrated electronics and tissue engineering because of their high stretchability, imperfection insensitivity, high permeability, and biomimetic J-shaped stress-strain responses. However, the fabrication of three-dimensionally (3D) architected electronic devices with ordered constructions of network microstructures remains challenging. Here, we introduce the tensile buckling of stacked multilayer precursors as a unique route to 3D network materials with regularly distributed 3D microstructures.
View Article and Find Full Text PDFClin Anat
September 2025
Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea.
Plantar melanomas present unique diagnostic and surgical challenges owing to substantial regional variations in skin thickness. Although the Breslow thickness remains the primary criterion for staging and surgical excision, its application on plantar melanoma is complicated by the inherent thickness of the glabrous plantar epidermis, which may lead to tumor depth overestimation. Accurate assessment of plantar skin thickness is essential for optimizing staging accuracy and refining surgical margins.
View Article and Find Full Text PDFRegen Biomater
August 2025
Institute of Stomatology & Oral Maxilla Facial Key Laboratory, First Medical Center of Chinese PLA General Hospital, Beijing 100853, China.
Reconstructing bone defects remains a significant challenge in clinical practice, driving the urgent need for advanced artificial grafts that simultaneously promote vascularization and osteogenesis. Addressing the critical trade-off between achieving high porosity/strength and effective bioactivity at safe ion doses, we incorporated strontium (Sr) into β-tricalcium phosphate (β-TCP) scaffolds with a triply periodic minimal surface (TPMS) structure using digital light processing (DLP)-based three-dimensional (3D) printing. Systematically screening Sr concentrations (0-10 mol%), we identified 10 mol% as optimal, leveraging the synergy between the biomimetic TPMS architecture, providing exceptional mechanical strength (up to 1.
View Article and Find Full Text PDFPLoS One
September 2025
Mechanical and Nuclear Engineering Department, Khalifa University of Science and Technology, Abu Dhabi, United Arab Emirates.
Sectionally nonlinearly functionally graded (SNFG) structures with triply periodic minimal surface (TPMS) are considered ideal for bone implants because they closely replicate the hierarchical, anisotropic, and porous architecture of natural bone. The smooth gradient in material distribution allows for optimal load transfer, reduced stress shielding, and enhanced bone ingrowth, while TPMS provides high mechanical strength-to-weight ratio and interconnected porosity for vascularization and tissue integration. Wherein, The SNFG structure contains sections with thickness that varies nonlinearly along their length in different patterns.
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