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This study investigated the clinical outcomes of the modified combined dorsal-volar approach for internal fixation of comminuted distal radius fractures complicated by scaphoid fractures resulting from high-energy trauma. A cohort of 100 patients with concurrent distal radius and scaphoid fractures underwent surgical management by this approach. Postoperative assessments included wrist joint function recovery, operative parameters (surgical time, intraoperative blood loss, and hospital stay), range of motion (ROM), functional scores (Disabilities of the Arm, Shoulder, and Hand [DASH], Bartra, and Gartland-Werley), fracture healing-related indicators, and serum inflammatory cytokine levels. Univariate and multivariate analyses were performed to identify independent predictors of wrist functional recovery. The results demonstrated an 88.0% excellent-to-good rate for postoperative wrist function. The mean surgical time was 141.39±20.21 minutes, with intraoperative blood loss averaging 114.84±24.87 mL and a mean hospital stay of 12.01±4.35 days. Significant improvements were observed in ROM, functional scores, and fracture healing-related measures, alongside a marked reduction in inflammatory cytokines. Age (odds ratio [OR] =14.194), DASH score (OR=1.395), and Gartland-Werley score (OR=1.431) were identified as independent prognostic factors for wrist functional recovery. These findings underscore the effectiveness of the modified combined dorsal-volar approach in restoring wrist joint function, facilitating fracture union, and mitigating inflammatory responses in patients with these conditions.
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http://dx.doi.org/10.62347/QXOH9563 | DOI Listing |
Philos Trans A Math Phys Eng Sci
September 2025
Department of Mathematics, University of York, York, UK.
The combined effect of axial stretching and cross-stream diffusion on the downstream transport of solute is termed Taylor dispersion. The dispersion of active suspensions is qualitatively distinct: viscous and external torques can establish non-uniform concentration fields with weighted access to shear, modifying mean drift and effective diffusivity. It would be advantageous to fine-tune the dispersion for systems such as bioreactors, where mixing or particle separation can improve efficacy.
View Article and Find Full Text PDFAnal Bioanal Chem
September 2025
School of Artificial Intelligence, Hangzhou Dianzi University, Hangzhou, 310018, China.
The prompt and accurate identification of pathogenic bacteria is crucial for mitigating the transmission of infections. Conventional detection methods face limitations, including lengthy processing, complex sample pretreatment, high instrumentation costs, and insufficient sensitivity for rapid on-site screening. To address these challenges, an aptamer (Apt)-sensor based on functionalized magnetic nanoparticles (MNPs) was developed for detecting Escherichia coli.
View Article and Find Full Text PDFBMJ Open
September 2025
Department of Gastroenterology, Hepatology, Infectious Diseases and Intoxication, University Hospital Heidelberg, Heidelberg, Germany.
Introduction: Combined vascular endothelial growth factor/programmed death-ligand 1 blockade through atezolizumab/bevacizumab (A/B) is the current standard of care in advanced hepatocellular carcinoma (HCC). A/B substantially improved objective response rates compared with tyrosine kinase inhibitor sorafenib; however, a majority of patients will still not respond to A/B. Strong scientific rationale and emerging clinical data suggest that faecal microbiota transfer (FMT) may improve antitumour immune response on PD-(L)1 blockade.
View Article and Find Full Text PDFBMJ Open
September 2025
Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China
Introduction: Intracranial atherosclerosis is the main cause of stroke globally, with acute large vessel occlusive (LVO) stroke being a predominant contributor to stroke-related mortality. In recent years, aspiration thrombectomy (AT) has emerged as a novel therapeutic method for treating acute LVO stroke. The purpose of this study aims to investigate the safety and efficacy of AT alone or combined with stent retriever thrombectomy (SRT) in the treatment of acute LVO stroke METHODS AND ANALYSIS: This is a multicentre and observational real-world study involving patients diagnosed with acute LVO stroke.
View Article and Find Full Text PDFNucleic Acids Res
September 2025
Expression génétique microbienne, UMR8261 CNRS, Université Paris Cité, Institut de Biologie Physico-Chimique, Paris 75005, France.
Targeted gene editing can be achieved using CRISPR-Cas9-assisted recombineering. However, high-efficiency editing requires careful optimization for each locus to be modified, which can be tedious and time-consuming. In this work, we developed a simple, fast and cheap method: Engineered Assembly of SYnthetic operons for targeted editing (EASY-edit) in Escherichia coli.
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